DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpa and MCM5

DIOPT Version :9

Sequence 1:	NP_001286160.1	Gene:	dpa / 35679	FlyBaseID:	FBgn0015929	Length:	866	Species:	Drosophila melanogaster
Sequence 2:	NP_178812.1	Gene:	MCM5 / 815415	AraportID:	AT2G07690	Length:	727	Species:	Arabidopsis thaliana

Alignment Length:	728	Identity:	242/728 - (33%)
Similarity:	376/728 - (51%)	Gaps:	78/728 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   147 SQAPQLVVWGTNVVVS--QCKSKFKSFIMRFIDPSAEQDEISENIDVNQPLYLQKLEEIHTLEEP 209
            |..||....|....:|  ...:|||.||..|        ||.:|...    |.:.|     |:.|
plant    12 SDQPQFPEAGDAATISPHAVLTKFKEFIRNF--------EIEQNCFP----YREAL-----LDNP 59

  Fly   210 -YLNLNCAHLKTFDQDLYRQLICYPQEVIPGFDMAINEMFF-----ERYPAALLE----HQIQVR 264
             .|.::...|.:||.||...:...|.:.:|.|:.|..|:..     |.....::|    ..:|:.
plant    60 KRLVVHLEDLLSFDSDLPSLIRSAPADYLPVFEKAAGEVLTGLKMREANEGGVMEEPLTRDVQIL 124

  Fly   265 PFNADKTRNMRSLNPEDMDQLISISGMVIRSSNVIPEMREAFFSCNICSFSTTVEV----DRGRI 325
            ..:.:...:||.|..:.:.:|:.|||:.|.:|.|..:....|..|..|  ..|.||    ..|..
plant   125 LTSREDPVSMRLLGAQYISKLVKISGISIAASRVKAKATYVFLVCKNC--KKTREVPCRPGLGGA 187

  Fly   326 NQPTLCTNC---NTNHC----FRLIHNRSEFTDKQLVKLQESPDDMAAGQTPHNVLLYAHNDLVD 383
            ..|..|.|.   ....|    :.::.:||::.|:|.:||||:|:|:..|:.|.|:||.....||.
plant   188 IVPRSCDNIPQPGEEPCPLDPWMVVPDRSQYVDQQTLKLQENPEDVPTGELPRNMLLSVDRHLVQ 252

  Fly   384 KVQPGDRVTVTGIYRATPLKTGGLSSSVK---SVYKTHVDVVHFRKVDNKRLYEDEEGKDHIFPP 445
            .:.||.|:||.|||  :..:....|:|.|   ::.:.::.||.....:.    ....|..: |.|
plant   253 TIVPGTRLTVMGIY--SIFQASSSSNSHKGAVAIRQPYIRVVGLEDTNE----ASSRGPAN-FTP 310

  Fly   446 ERVELLQLLAKKPDIYDRLARAIAPSIYENDDIKKGILLQLFGGTKKKHATLGRQNFRSEIHLLL 510
            :..|..:..|...|:|..:...|||||:.::|:|:.....||||::|  :.......|.:|::||
plant   311 DEEEEFKKFADSQDVYKNICTKIAPSIFGHEDVKRAAACLLFGGSRK--SLPDGVKLRGDINVLL 373

  Fly   511 CGDPGTSKSQMLQYVFNLVPRSQYTSGRGSSAVGLTAYVTKDPETRQLVLQTGALVLADNGVCCI 575
            .|||.|:|||.|::|....|.:.||||:||||.||||.|.:|..||:..|:.||:||||.||.||
plant   374 LGDPSTAKSQFLKFVEKTAPIAVYTSGKGSSAAGLTASVIRDSSTREFYLEGGAMVLADGGVVCI 438

  Fly   576 DEFDKMNDSTRSVLHEVMEQQTLSIAKAGIICQLNARTSILAAANPAESQWNKRKNIIDNVQLPH 640
            ||||||....|..:||.|||||:|||||||...||:|||:||||||...:::..|...||:.|..
plant   439 DEFDKMRPEDRVAIHEAMEQQTISIAKAGITTVLNSRTSVLAAANPPSGRYDDLKTAQDNIDLQT 503

  Fly   641 TLLSRFDLIFLVLDPQDEIFDKRLASHLVSLY-YVTRHEEEDT-MFDMSVLRDYIAYAREHLSPT 703
            |:||||||||:|.|.:....||.:|||::.:: ...:..:|:| ..:.:.|:.||.|.|....|.
plant   504 TILSRFDLIFIVKDIRKYSQDKEIASHIIRVHASANKFSDENTDSKEDNWLKRYIQYCRARCHPR 568

  Fly   704 LSDEAQQRLIQAYV----DMRKVGAGRGQISAYP---RQLESLIRLSEAHAKVRLSNQVELLDVE 761
            ||.:|.:.|.:.||    ||::.....|:.:..|   ||||:::||||:.||:|||::....||:
plant   569 LSKDAAENLQRKYVTIRMDMKRRAHETGEAAPIPITVRQLEAIVRLSESLAKMRLSHEATPDDVD 633

  Fly   762 EAWRLHREALKQSATDPLSGKIDV-GILTTGLSTAAR--KKRADLVAAIK-----ENLKKKG--- 815
            :|::|...:...:|...::.:|:: |.:...:..|..  |:|..:.|.:.     |:|.:.|
plant   634 KAFKLFDTSTMDAARSGINQQINITGEMANEIKQAETQIKRRMGIGARLSERRLIEDLARMGMND 698

  Fly   816 ----KVLTVPYQK 824
                :.|.:.:|:
plant   699 SMVRRALLIMHQR 711

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpa	NP_001286160.1	PHA03307	2..>150	CDD:223039	1/2 (50%)
		MCM_N	168..267	CDD:379644	26/108 (24%)
		MCM	270..772	CDD:214631	198/524 (38%)
MCM5	NP_178812.1	MCM_N	35..127	CDD:379644	26/108 (24%)
MCM5	NP_178812.1	MCM	131..644	CDD:214631	198/523 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D266497at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820