DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpa and mcm8

DIOPT Version :9

Sequence 1:	NP_001286160.1	Gene:	dpa / 35679	FlyBaseID:	FBgn0015929	Length:	866	Species:	Drosophila melanogaster
Sequence 2:	NP_001072344.1	Gene:	mcm8 / 779797	XenbaseID:	XB-GENE-961372	Length:	843	Species:	Xenopus tropicalis

Alignment Length:	845	Identity:	241/845 - (28%)
Similarity:	391/845 - (46%)	Gaps:	144/845 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   100 GIRGTPLRARPDIRTDKRIRQVAIGGGSGLEPIPEKGSETTDPV--SESSQAPQLVVWGTNVVVS 162
            |.||.|.|.|..             |||.      ..:...|||  |.:...|||.....:..:
Frog    21 GWRGRPWRGRGQ-------------GGSW------SRNSGRDPVCFSTAPPKPQLTQTTLDKYI- 65

  Fly   163 QCKSKFKSFIMRFIDPSAEQDEISENIDVNQPLYLQKLE-----EIH---TLEEPYLNLNCAHLK 219
                .:|.:.:.|.:..::.....|.:...:..:.:::|     ||.   ::...|.:|
Frog    66 ----PYKGWKLYFSEAYSDSSPFLEKVRAFEKFFTKQIELYDKDEIERKGSILVDYKDL------ 120

  Fly   220 TFDQDL------YRQLICYPQEVIPGFDMAINEMF---FERYPAALLEHQ--------------I 261
            ..|:||      ..:|...|::::....:||:::.   .||:.|.|.|.:              |
Frog   121 LQDEDLSASIPMSSELKEMPEKILECMGLAIHQVLTKDLERHAAELQEQEGLRTEEAPIVNVPFI 185

  Fly   262 QVRPFNADKTRNMRSLNPEDMDQLISISGMVIRSSNVIPEMREAFFSCNICSFSTTVEVDRGRIN 326
            ..|.||.|....:::|......:.:::.|.|:|.||:.|...:..||||:|....:.....|:..
Frog   186 HARVFNYDPLTPLKNLRASLYGKYVALRGTVVRVSNIKPLCVKMAFSCNMCGDIQSFPFPDGKYA 250

  Fly   327 QPTLC--TNCNTNHCFRLIHNRSE----FTDKQLVKLQE--SPDDMAAGQTPHNVLLYAHNDLVD 383
            .||.|  ..|...   ....|||.    ..|.|.:|:||  |.|...||:.|..|......||||
Frog   251 VPTKCPVPECRGR---SFTANRSSPLTVTVDWQTIKVQELMSDDQREAGRIPRTVECELIQDLVD 312

  Fly   384 KVQPGDRVTVTGIYRATPLKTGGL-SSSVKSVYKTHVDVVHFRKVDNKRLY-----EDEE--GKD 440
            ...|||.||||||.:.:..:.||. :.:.|.::..:::.   ..|.|.:.:     :|.|  |..
Frog   313 SCVPGDMVTVTGIVKVSNTRDGGFKNKNNKCMFLLYIEA---NSVSNSKGHKIKSTDDSESHGAS 374

  Fly   441 HIFPPERVELLQLLAKKPDIYDRLARAIAPSIYENDDIKKGILLQLFGGTKKKHATLGRQNFRSE 505
            ..|..:.:..:|.:..:.:::..:..::.|:||.::.:|.|:.|.||||.:|......|...|.:
Frog   375 MDFSLKDLYAIQEIQAQENLFQLIVNSLCPTIYGHELVKAGLSLALFGGCQKYADDKNRIPIRGD 439

  Fly   506 IHLLLCGDPGTSKSQMLQYVFNLVPRSQYTSGRGSSAVGLTAYVTKDPETRQLVLQTGALVLADN 570
            .|:|:.||||..||||||.|.|:.||..|..|..::..|||..:::|..|....|:.|||:|.|.
Frog   440 PHILVVGDPGLGKSQMLQAVCNVAPRGVYVCGNTTTTSGLTVTLSRDSATGDFGLEAGALILGDQ 504

  Fly   571 GVCCIDEFDKMNDSTRSVLHEVMEQQTLSIAKAGIICQLNARTSILAAANPAESQWNKRKNIIDN 635
            |:|.|||||||.:..:::| |.||||::|:|||||:|.|.|||||:|||||....:||.|.:.:|
Frog   505 GICGIDEFDKMGNQHQALL-EAMEQQSISLAKAGIVCSLPARTSIIAAANPVGGHYNKGKTVSEN 568

  Fly   636 VQLPHTLLSRFDLIFLVLDPQDEIFDKRLASHLVSLYY-------------VTRHEEEDTMFDMS 687
            :::...|||||||:|::||..:|..|..|:.|::::..             .|::.....:.:.|
Frog   569 LKMGSALLSRFDLVFILLDTPNEDHDHLLSEHVMAMRAGAKEMQSADLTCPTTQNSNTSVLEEPS 633

  Fly   688 ----------------------VLRDYIAYAREHLSPTLSDEAQQRLIQAYVDMRKVGAGRGQIS 730
                                  :||.|:.|||:::.||||.:|.|.|...|:::||...|.....
Frog   634 ERPLGERLKLRPGEHFDPIPHQLLRKYVGYARQYVHPTLSPDAAQVLQDFYLELRKQNQGIDSTP 698

  Fly   731 AYPRQLESLIRLSEAHAKVRLSNQVELLDVEEAWRLHREALKQSATDPLSGKIDVGILTTGLSTA 795
            ...|||||||||:||.|::.|..:....|.||..::.:.:|..:.:|.. ||:|......|...:
Frog   699 ITTRQLESLIRLTEARARLELREKATKDDAEEVVQIMKYSLLGTFSDEF-GKLDFHRSQHGSGMS 762

  Fly   796 ARKKRADLVAAIKENLKKKGKVLTVPYQKLFSDIKEGSQIMITREQFEDALKEVQDEGAIVVMGK 860
            .|.|....::|:       .::....|..||              :|:. |:::..|..|.::||
Frog   763 NRSKAKKFISAL-------NRIAEQTYNNLF--------------EFQQ-LRQIAKELQIQLLGK 805

Fly 861 860
Frog 806 805

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpa	NP_001286160.1	PHA03307	2..>150	CDD:223039	13/51 (25%)
		MCM_N	168..267	CDD:379644	22/129 (17%)
		MCM	270..772	CDD:214631	182/552 (33%)
mcm8	NP_001072344.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..52		13/49 (27%)
		Mcm2	93..769	CDD:224162	212/689 (31%)
		MCM8	397..738	CDD:350665	128/341 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920