DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpa and Mcm8

DIOPT Version :9

Sequence 1:	NP_001286160.1	Gene:	dpa / 35679	FlyBaseID:	FBgn0015929	Length:	866	Species:	Drosophila melanogaster
Sequence 2:	NP_001277983.1	Gene:	Mcm8 / 66634	MGIID:	1913884	Length:	833	Species:	Mus musculus

Alignment Length:	832	Identity:	230/832 - (27%)
Similarity:	385/832 - (46%)	Gaps:	122/832 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 RTDKRIRQVAIGGGSGLEPIPEKGSETTDPVSESSQAPQLVVW-GTNVVVSQCKSK--------- 167
            |..:|..:|.:...||    ....::.:.|:.:.|...|.:.: |..:..|:..|.
Mouse    30 RWRERENRVDLNEASG----KHASAQASQPLLQQSTLDQFIPYKGWKLYFSEVYSNNSPFIEKIQ 90

  Fly   168 -FKSFIMRFIDPSAEQDEISEN----IDVNQPLYLQKLEEIHTLEEPYLNLNCAHLKTFDQDLYR 227
             |:.|..|.|| ..::|||...    :|..:   |.|.:||..|               ..|:..
Mouse    91 AFEKFFTRHID-LYDKDEIERKGSILVDFKE---LTKADEITNL---------------IPDIEN 136

  Fly   228 QLICYPQEVIPGFDMAINEMF---FERYPAALLEHQ--------------IQVRPFNADKTRNMR 275
            .|...|::.:....:||:::.   .||:.|.|...:              |..|.:|.:...:::
Mouse   137 ALRDAPEKTLACMGLAIHQVLTKDLERHAAELQAQEGLSNGGETMVNVPHIYARVYNYEPLTHLK 201

  Fly   276 SLNPEDMDQLISISGMVIRSSNVIPEMREAFFSCNICSFSTTVEVDRGRINQPTLC--TNCNTNH 338
            ::......:.|||.|.|:|.||:.|......|.|..|....:..:..|:...||.|  ..|....
Mouse   202 NIRATCYGKYISIRGTVVRVSNIKPLCTNMAFQCAACGEIQSFPLPDGKYTLPTKCPVPACRGRS 266

  Fly   339 CFRLIHNRSEFT-DKQLVKLQESPDD--MAAGQTPHNVLLYAHNDLVDKVQPGDRVTVTGIYRAT 400
            ...|..:....| |.||:|:||...|  ..||:.|..:.....:||||...|||.||||||.:.:
Mouse   267 FAPLRSSPLTVTLDWQLIKIQELMSDAQREAGRIPRTIECELVHDLVDSCVPGDTVTVTGIVKVS 331

  Fly   401 PLKTGGLSSSVKSVYKTHVDVVHFRKVDNKRLYEDEEGKDH----IFPPERVELLQLLAKKPDIY 461
            ..:.|..:.:.|.::..:::..........:....|:|..|    .|..:.:..::.:..:.::.
Mouse   332 NSEEGSRNKNDKCMFLLYIEANSVSNSKGPKAQTAEDGCKHGTLMEFSLKDLYAIREIQAEENLL 396

  Fly   462 DRLARAIAPSIYENDDIKKGILLQLFGGTKKKHATLGRQNFRSEIHLLLCGDPGTSKSQMLQYVF 526
            ..:..::.|.|:.::.:|.|:.|.||||::|......|...|.:.|:|:.||||..||||||...
Mouse   397 KLVVNSLCPVIFGHELVKAGLTLALFGGSQKYADDKNRIPIRGDPHVLIVGDPGLGKSQMLQAAC 461

  Fly   527 NLVPRSQYTSGRGSSAVGLTAYVTKDPETRQLVLQTGALVLADNGVCCIDEFDKMNDSTRSVLHE 591
            |:.||..|..|..:::.|||..::||..:....|:.|||||.|.|:|.|||||||.:..:::| |
Mouse   462 NVAPRGVYVCGNTTTSSGLTVTLSKDSSSGDFALEAGALVLGDQGICGIDEFDKMGNQHQALL-E 525

  Fly   592 VMEQQTLSIAKAGIICQLNARTSILAAANPAESQWNKRKNIIDNVQLPHTLLSRFDLIFLVLDPQ 656
            .||||::|:||||::|.|.|||||:|||||....:||.:.:.:|:::...|||||||:|::||..
Mouse   526 AMEQQSISLAKAGVVCSLPARTSIIAAANPVGGHYNKARTVSENLKMGSALLSRFDLVFILLDTP 590

  Fly   657 DEIFDKRLASHL----------VSLYYVTRHEEEDTMFDM------------------------- 686
            :|..|..|:.|:          ||...|||...:|:...:
Mouse   591 NEQHDHLLSEHVIAIRAGKQKAVSSATVTRVLSQDSNTSVLEVVSEKPLSERLKVAPGEQTDPIP 655

  Fly   687 -SVLRDYIAYAREHLSPTLSDEAQQRLIQAYVDMRKVGAGRGQISAYPRQLESLIRLSEAHAKVR 750
             .:||.||.|||:::.|.||.:|.|.|...|:::||.....|......|||||||||:||.|::.
Mouse   656 HQLLRKYIGYARQYVHPRLSTDAAQALQDFYLELRKQSQRVGSSPITTRQLESLIRLTEARARLE 720

  Fly   751 LSNQVELLDVEEAWRLHREALKQSATDPLSGKIDV-----GILTTGLSTAARKKRADLVAAIKEN 810
            |..:....|.|:...:.:.::..:.:|.. |.:|.     |   :|:|..:..||  .::|:...
Mouse   721 LREEATREDAEDIIEIMKHSMLGTYSDEF-GNLDFERSQHG---SGMSNRSTAKR--FISALNSI 779

  Fly   811 LKKKGKVLTVPYQKLFS--DIKE-GSQIMITREQFEDALKEVQDEGAIVVMG 859
            .::       .|..:|.  .::: ..::.|....||:.:..:.|:|.::..|
Mouse   780 AER-------TYNNIFQYHQLRQIAKELNIQVADFENFIGSLNDQGYLLKKG 824

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpa	NP_001286160.1	PHA03307	2..>150	CDD:223039	7/36 (19%)
		MCM_N	168..267	CDD:379644	25/119 (21%)
		MCM	270..772	CDD:214631	176/546 (32%)
Mcm8	NP_001277983.1	MCM_N	91..216	CDD:291233	29/143 (20%)
		Mcm2	132..830	CDD:224162	205/707 (29%)
		AAA	428..586	CDD:99707	74/158 (47%)
		PEPcase	<676..>747	CDD:304407	22/70 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820