DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpa and mcm6

DIOPT Version :9

Sequence 1:	NP_001286160.1	Gene:	dpa / 35679	FlyBaseID:	FBgn0015929	Length:	866	Species:	Drosophila melanogaster
Sequence 2:	NP_001076318.1	Gene:	mcm6 / 566409	ZFINID:	ZDB-GENE-030909-6	Length:	830	Species:	Danio rerio

Alignment Length:	848	Identity:	241/848 - (28%)
Similarity:	394/848 - (46%)	Gaps:	188/848 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   160 VVSQCKSKFKSFIMRFIDPSAEQDEISENIDVNQPLYLQKLEEIHTLEEPYLNLNCAHLKTFDQD 224
            :..:|:..|::|:..|           :|.| .:..||:..||:...|...|.::...|:.|:|:
Zfish    20 LAEKCQKLFQAFLEEF-----------QNSD-GEVKYLRDAEELIRPERNTLAVSFTDLEGFNQE 72

  Fly   225 LYRQLICYPQEVIPGFDMAINEMFFERYPAALLEHQIQVRPFNAD-----------------KTR 272
            |               ..||.|.|:..||....    .||.|..:                 .||
Zfish    73 L---------------ATAIQEEFYRLYPYLCR----AVRNFAREHGEVPTSKEFYVAFQDLPTR 118

  Fly   273 N-MRSLNPEDMDQLISISGMVIRSSNVIPEMREAFFSCNICSFSTTVEVDRGRINQPTLCTN--C 334
            : :|.|....:..|:.|||.|:|:..|.||:....|.|..|.........:.:..||::|.|  |
Zfish   119 HKIRELTTVKVGSLVRISGQVVRTHPVHPELVSGTFLCLDCQGVIKDVEQQFKYTQPSICRNPVC 183

  Fly   335 NTNHCFRLIHNRSEFTDKQLVKLQESPDDMAAGQTPHNVLLYAHNDLVDKVQPGDR--------- 390
            |....|.|..|:|:|.|.|.:::||:..::..|..|.::.:....:.|:..|.||:
Zfish   184 NNRRRFLLDTNKSKFIDFQKLRIQETQAELPRGSIPRSMEVILRAEAVESAQAGDKCDFIGSLIV 248

  Fly   391 ------VTVTGIYRATPLKTGGLSS-------SVKSV------YKTHVDVVHFR----KVDNKRL 432
                  :...|:...|..:|.|:..       .:|::      ||......|..    :...|.:
Zfish   249 VPDISQLATPGVRAETSSRTAGVQGYENEGLRGLKALGVRELSYKLAFLACHVAPTNPRFGGKEI 313

  Fly   433 YEDEEGKDHI---FPPERVELLQLLAKKPDIYDRLARAIAPSIYENDDIKKGILLQLFGGTKKKH 494
            .::|:..:.|   ...:..|.:..:::..::|..|..::.|:|:.||::|:||||.||||..|
Zfish   314 RDEEQTAESIKKQMSVQEWEKVFEMSQDKNLYHNLCTSLFPTIHGNDEVKRGILLMLFGGVPK-- 376

  Fly   495 ATLGRQNFRSEIHLLLCGDPGTSKSQMLQYVFNLVPRSQYTSGRGSSAVGLTAYVTKDPETRQLV 559
            .|:...:.|.:|::.:.|||.|:|||.|::|....||:.||||:.|||.||||.|.:|.|:.:.|
Zfish   377 TTMEGTSLRGDINVCVVGDPSTAKSQFLKHVEEFCPRAVYTSGKASSAAGLTAAVVRDEESHEFV 441

  Fly   560 LQTGALVLADNGVCCIDEFDKMNDSTRSVLHEVMEQQTLSIAKAGIICQLNARTSILAAANPAES 624
            ::.|||:|||||||||||||||....:..:||.|||||:||.|||:...|||||||||||||...
Zfish   442 IEAGALMLADNGVCCIDEFDKMETRDQVAIHEAMEQQTISITKAGVKATLNARTSILAAANPVSG 506

  Fly   625 QWNKRKNIIDNVQLPHTLLSRFDLIFLVLDPQDEIFDKRLASHLVSLYYVTRHEEE-DTMFDMSV 688
            ::::.|::..||.|...::|||||.|:::|..:|:.|..:|..:|.|:  :|.|.. |.::.:..
Zfish   507 RYDRSKSLKQNVNLTAPIMSRFDLFFILVDDCNEVTDYAIARRIVDLH--SRIENSVDRVYSLDE 569

  Fly   689 LRDYIAYAREHLSPTLSDEAQQRLIQAYVDMRKVGAGRGQISAY---PRQLESLIRLSEAHAKVR 750
            :|.|:.:||: ..|.:|.|:::.:::.|..:|:........||:   .|||||||||||:.|::.
Zfish   570 IRRYLLFARQ-FKPKISKESEEFIVEQYKRLRQRDGSGVTKSAWRITVRQLESLIRLSESMARMH 633

  Fly   751 LSNQVELLDVEEAWRL------------------HREALKQSATDPLSGKIDV------------ 785
            ..::|:...|:||:||                  ..||:::...:.::|. ||
Zfish   634 CCDEVQPKHVKEAFRLLNKSIIRVETPDVNLDQEEEEAMEEEEDNQMNGH-DVPNGVNGAVNGEV 697

  Fly   786 -------GILTTG-----------LSTAARKKRADLV-------------AAIK----------- 808
                   ||...|           ||.|..|:.::|:             ||:|
Zfish   698 NGHEHTNGINGHGVNGETAKPSLRLSFAEYKRISNLLVLHLRRAEEDEDEAALKKSEVVNWYLKE 762

  Fly   809 ---------ENLKKKGKVLTVPYQKLFSDIKEGSQIMITREQ------FEDALKEVQDEGAIVVM 858
                     |.:.||..:..|.|:.:..|     .|:|..:|      .|.:..|.|:|...:|:
Zfish   763 IESEIDSEMELISKKTMIEKVIYRLVHYD-----YILIELKQSGLKGSAESSETESQEEDVTLVV 822

  Fly   859 GKN 861
            ..|
Zfish   823 NPN 825

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpa	NP_001286160.1	PHA03307	2..>150	CDD:223039
		MCM_N	168..267	CDD:379644	23/98 (23%)
		MCM	270..772	CDD:214631	187/561 (33%)
mcm6	NP_001076318.1	MCM_N	27..137	CDD:291233	30/140 (21%)
		MCM	117..655	CDD:214631	185/542 (34%)
		P-loop_NTPase	<445..532	CDD:304359	52/86 (60%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820