DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpa and mcm5

DIOPT Version :9

Sequence 1:	NP_001286160.1	Gene:	dpa / 35679	FlyBaseID:	FBgn0015929	Length:	866	Species:	Drosophila melanogaster
Sequence 2:	NP_001017327.2	Gene:	mcm5 / 550081	XenbaseID:	XB-GENE-985665	Length:	735	Species:	Xenopus tropicalis

Alignment Length:	755	Identity:	253/755 - (33%)
Similarity:	388/755 - (51%)	Gaps:	96/755 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   136 GSETTDPVSESSQAPQLVVWGTNVVVSQCKSKFKSFIMRFIDPSAEQDEISENIDVNQP----LY 196
            |.|  .||.:..||.:          ||.|.:|:.|:.::            .:..::.    .|
Frog    16 GGE--QPVGDDGQAKK----------SQLKKRFREFLRQY------------RVGTDRTGFTFKY 56

  Fly   197 LQKLEEIHTLEEPYLNLNCAHLKTFDQDLYRQLICYPQEVIPGFDMAINEMFFE---RYPA---A 255
            ..:|:..:.|.|.::.:....|.:||:||...|...|.|.:...:.|..|:..|   ..||   .
Frog    57 RDELKRHYNLGEYWIEVEMEDLASFDEDLADYLYKQPTEHLQLLEEAAQEVADEVTRPRPAGEET 121

  Fly   256 LLEHQIQVRPFNADKTRNMRSLNPEDMDQLISISGMVIRSSNVIPEMREAFFSCNICSFSTTVEV 320
            :.|.|:.:|  :.....|:|||..|.|..|:.|.|::|.::.|..:..:....|..|..:.....
Frog   122 IQEIQVMLR--SDANPANIRSLKSEQMSHLVKIPGIIIAATAVRAKATKISIQCRSCRNTIGNIA 184

  Fly   321 DRGRINQPTLCTNCNTNHCFR---------LIHNRSEFTDKQLVKLQESPDDMAAGQTPHNVLLY 376
            .|..:....:...|||....|         :|.::.:..|.|.:|||||||.:..|:.|.::.||
Frog   185 VRPGLEGYAMPRKCNTEQAGRPKCPLDPYFIIPDKCKCVDFQTLKLQESPDAVPHGELPRHMQLY 249

  Fly   377 AHNDLVDKVQPGDRVTVTGIYRATPLKTGGLSSSVK-----SVYKTHVDVVHFRKVDNKRLYEDE 436
            ....|.|||.||:|||:.|||...  |:|..|:..:     .:..:::.||.. :||.:......
Frog   250 CDRYLCDKVVPGNRVTIMGIYSIR--KSGKTSTKGRDRVGVGIRSSYIRVVGI-QVDTEGTGRSA 311

  Fly   437 EGKDHIFPPERVELLQLLAKKPDIYDRLARAIAPSIYENDDIKKGILLQLFGGTKKKHAT-LGRQ 500
            .|.  |.|.|..|..:|.| |||||:.:|::||||||.:.||||.|...||||::|:... |.|
Frog   312 AGA--ITPQEEEEFRRLSA-KPDIYETVAKSIAPSIYGSSDIKKAIACLLFGGSRKRLPDGLTR- 372

  Fly   501 NFRSEIHLLLCGDPGTSKSQMLQYVFNLVPRSQYTSGRGSSAVGLTAYVTKDPETRQLVLQTGAL 565
              |.:::||:.|||||:|||:|::|....|...||||:||||.||||.|.:||.:|..:::.||:
Frog   373 --RGDVNLLMLGDPGTAKSQLLKFVERCSPIGVYTSGKGSSAAGLTASVMRDPVSRNFIMEGGAM 435

  Fly   566 VLADNGVCCIDEFDKMNDSTRSVLHEVMEQQTLSIAKAGIICQLNARTSILAAANPAESQWNKRK 630
            ||||.||.||||||||.:..|..:||.|||||:|||||||...||:|.|:|||||....:|:..|
Frog   436 VLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGITTTLNSRCSVLAAANSVYGRWDDTK 500

  Fly   631 NIIDNVQLPHTLLSRFDLIFLVLDPQDEIFDKRLASHLVSLYYVTRHEEE--DTMFDMSVLRDYI 693
            . .:|:....|:|||||:||:|.|..:|..|..||.|:::::...|.:..  :...|::.|:.||
Frog   501 G-EENIDFMPTILSRFDMIFIVKDEHNEQRDMTLAKHVMNVHLSARTQSSSVEGEIDLNTLKKYI 564

  Fly   694 AYAREHLSPTLSDEAQQRLIQAYVDMRKVGA--------GRGQISAYPRQLESLIRLSEAHAKVR 750
            ||.|....|.||.|:.::|...|:.||. ||        .|..|....||||:::|:||:..|::
Frog   565 AYCRAKCGPRLSAESAEKLKNRYILMRS-GARDHERETEKRSSIPITVRQLEAIVRISESLGKMK 628

  Fly   751 LSNQVELLDVEEAWRLHREALKQSATDPLSGKIDVGILTTGLSTAARKKRADLVAAIKENLKKKG 815
            |.......|||||.||.:.:...:|   :||.:      :|:.....::..::::.|::.||::.
Frog   629 LQPFATETDVEEALRLFQVSTLDAA---MSGSL------SGVEGFTTQEDQEMLSRIEKQLKRRF 684

  Fly   816 KVLTVPYQKLFSDIKEGSQIMITREQFEDALKEVQDEGAI 855
            .:              |||:. .....:|.||:...|.||
Frog   685 AI--------------GSQVS-EHSIIQDFLKQKYPEHAI 709

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpa	NP_001286160.1	PHA03307	2..>150	CDD:223039	5/13 (38%)
		MCM_N	168..267	CDD:379644	22/108 (20%)
		MCM	270..772	CDD:214631	206/526 (39%)
mcm5	NP_001017327.2	MCM_N	36..131	CDD:379644	22/108 (20%)
		MCM	134..650	CDD:214631	206/526 (39%)
		Arginine finger	513..516		2/2 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920