DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpa and rec

DIOPT Version :9

Sequence 1:	NP_001286160.1	Gene:	dpa / 35679	FlyBaseID:	FBgn0015929	Length:	866	Species:	Drosophila melanogaster
Sequence 2:	NP_001262615.1	Gene:	rec / 49241	FlyBaseID:	FBgn0003227	Length:	885	Species:	Drosophila melanogaster

Alignment Length:	948	Identity:	203/948 - (21%)
Similarity:	376/948 - (39%)	Gaps:	228/948 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 GGATPKQGARTPTRGIASQDVETPMRMGPGRAVRPSDNISLPPTSPGNISLPATSPARGLGANMS 75
            |...|..|.|.|.:|            .||....|    |:||.:........|:..||..|::
  Fly    35 GRVIPAGGNRQPNQG------------EPGAPDAP----SVPPATRQPRGWSRTAGKRGRNAHL- 82

  Fly    76 EIDLSSPLNYGTPSSMGSIRT-----PR--SGIRGTPLRARPDIRTDKRIRQVAIGGGSGLEPIP 133
            :.....|.||..|.....:::     ||  ||.|...||.:.:...:...|.:|:      |...
  Fly    83 DCSFLRPENYAAPEDGLQVQSIAVDNPRAYSGWRLYFLREKYEEGNELATRIMAV------EAYY 141

  Fly   134 EKGSETTDPVSESSQAPQLVVWGTNVVVSQCKSKFKSFI-MRFIDPSAEQDEISENIDVNQPLYL 197
            ::...|.|          .|:.........|.:..||.. ::.:.||     :||:|..:....|
  Fly   142 QRNPHTFD----------FVMIRDRGFFPLCAAGIKSDAQLKEVWPS-----LSEDIREHPLRTL 191

  Fly   198 QKLE-EIHTLEEPYLNLNCAHLKTFDQDLYRQLICYPQE-VIPGFDMAINEMFFERYPAALLEHQ 260
            ..|. .:||:...: .|:|       .|....::..|:: |:|             .|..   .:
  Fly   192 GTLSLAMHTVVVNH-QLDC-------NDSTTAMVSTPEQYVLP-------------TPRV---RK 232

  Fly   261 IQVRPFNADKTRNMRSLNPEDMDQLISISGMVIRSSNVIPEMREAFFSCNICSFSTTVEVDRGRI 325
            |..||.:.....::..::...:|.|.||.|.|.........:....|.|:.|.....:. .||..
  Fly   233 IYARPDDFVPVESIEGISHSRVDTLFSIRGFVSNVGEPSYSLTWQAFRCSRCQMEIAMR-QRGTF 296

  Fly   326 NQPTLCTNCNTNHCFRLIHNRSEFTD-----------KQLVKLQESPDDMA---AGQTPHNVLLY 376
             ||. ...|..:.|..    |.||..           :|:::::||..::.   ....|..:.:.
  Fly   297 -QPR-PYQCKRSECVA----RDEFVPLRSSPYTRLSIRQIIRVEESSLNLVHDFETSMPAEMDVE 355

  Fly   377 AHNDLVDKVQPGDRVTVTGIYRATPLKTGGLSSSVKSVYKTHVDVVHFRKVDN-KRLYEDEEGKD 440
            ..:||||.|:.|..|.||||.:...|.....:....:..:.::..|..|...: ||.:.:.:
  Fly   356 LRHDLVDAVRVGQEVVVTGILKLQELGDDTTTGDTSNQMQPYLKAVSIRDASSIKREFSERD--- 417

  Fly   441 HIFPPERVELLQLLAKKPDIYDRLARAIAPSIYENDDIKKGILLQLFGGTKKKHATLGRQNFRSE 505
                   :|.:.::..:|:.:..|.::|||.:|.::..|...||.|.||.       |.:.  ..
  Fly   418 -------LEAIVMINAEPNSFKLLVQSIAPEVYGHELPKAACLLSLLGGK-------GAET--EA 466

  Fly   506 IHLLLCGDPGTSKSQMLQYVFNLVPRSQYTSG-RGSSA---VGLTAYVTKDPETRQLVLQTGALV 566
            |::||.||||..|:::||....:..|..:.|| ||:.:   :|:| :..::    :.|||.|:|:
  Fly   467 INVLLVGDPGIGKTKILQSCAQIAERGAHVSGKRGAQSAQQLGVT-FAGRN----KRVLQAGSLM 526

  Fly   567 LAD-NGVCCIDEFDKMNDSTRSVLHEVMEQQTLSIAKAGIICQLNARTSILAAANPAESQWNKRK 630
            :|. .|.|.:|:.||: .|.::||.:.::.:.:::..||......|:.|::|.|||...|:::.:
  Fly   527 MASGGGHCTLDDVDKL-ASKQAVLLQCLQSEEVNLPLAGAFASFPAQPSVIACANPQRGQYDEGR 590

  Fly   631 NIIDNVQLPHTLLSRFDLIFLVLDPQDEIFDKRLASHLVSLY------------YVTRHEEEDTM 683
            .::.|:.:..:||..|.|::::||...| .|..|.:|:.:|:            |..:.:..|:|
  Fly   591 YLLQNINISPSLLREFHLVYILLDKPSE-RDMSLTAHVRALHAGARKRARIAARYALKPKMSDSM 654

  Fly   684 FDMS------------------------------------------------VLRDYIAYAREHL 700
            .::|                                                :::.:::|||:.|
  Fly   655 CEVSLNVPAAGKDDDTIKTEDDNDSIMQQDYDLDKRLEVLPEEGDLDLLPPILIKKFLSYARQEL 719

  Fly   701 SPTLSDEAQQRLIQAYVDMR-----------KVGAGRGQISAYPRQLESLIRLSEAHAKVRLSNQ 754
            :|.|:::|...:::.:::::           ::|||         ||.::|.||:|.|::.||:.
  Fly   720 NPVLNEDASNAVLRYFLELKGSCNLDEDVSSQIGAG---------QLLAIIHLSQARARLDLSHV 775

  Fly   755 VELLDVEEAWRLHREALKQSATDPLSGKIDVGILTTGLSTAARKKRADLVAAIKENLKKKGKVLT 819
            |....|.:...|..|::.|  |....|....|....|.:.....|.|.|
  Fly   776 VSPQHVRDVIALLTESITQ--TSLKEGSSRQGTRGGGGAGGGAGKSAQL---------------- 822

  Fly   820 VPYQKLFSDIKEGSQIMITREQFE-DALKEVQDEGAIV 856
                :.|.::.:.....:.|..|| |.|||:.....|:
  Fly   823 ----RNFLELTKRRSAALGRRIFEFDELKEIGTRAGIL 856

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpa	NP_001286160.1	PHA03307	2..>150	CDD:223039	32/145 (22%)
		MCM_N	168..267	CDD:379644	21/101 (21%)
		MCM	270..772	CDD:214631	131/592 (22%)
rec	NP_001262615.1	RNR_PFL	<117..200	CDD:299130	18/103 (17%)
		MCM	243..792	CDD:214631	131/590 (22%)
		P-loop_NTPase	468..606	CDD:304359	42/143 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45449659
Domainoid	1	1.000	52	1.000	Domainoid score	I661
eggNOG	1	0.900	-	-		E1_COG1241
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11630
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.850