DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpa and mcm2

DIOPT Version :9

Sequence 1:	NP_001286160.1	Gene:	dpa / 35679	FlyBaseID:	FBgn0015929	Length:	866	Species:	Drosophila melanogaster
Sequence 2:	NP_001006772.1	Gene:	mcm2 / 448458	XenbaseID:	XB-GENE-999974	Length:	884	Species:	Xenopus tropicalis

Alignment Length:	676	Identity:	225/676 - (33%)
Similarity:	352/676 - (52%)	Gaps:	72/676 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   130 EPIPEKGSETTDPVS--ESSQAPQLVVWGTNVVVSQCKS------KFKSFIMRFIDPSAEQDEIS 186
            |..||:..|..:.:.  |..:...:..|     ||...:      :||:|:...:      ||..
Frog   143 EGAPEEDEEMIESIENLEDMKGHTVREW-----VSMAATRLEIYHRFKNFLRTHV------DEHG 196

  Fly   187 ENIDVNQPLYLQKLEEIHTLEEPYLNLNCAHLKTFDQDLYRQLICYPQEVIPGFDMAINEMFFER 251
            .|:      :.:|:.::....:..|.:|...|...:..|...|...|.|::..||.|..|:....
Frog   197 HNV------FKEKISDMCKENKESLVVNYEDLAAREHVLAYFLPEAPAEMLKIFDEAAKEVVLVM 255

  Fly   252 YPA-ALLEHQIQVRPFNADKTRNMRSLNPEDMDQLISISGMVIRSSNVIPEMREAFFSCNICSF- 314
            ||. ..:..:|.||..:......:|||....::|||..||:|...:.|:|::....::||.|:|
Frog   256 YPKYDRIAREIHVRISHLPLVEELRSLRQLHLNQLIRTSGVVTCCTGVLPQLSMVKYNCNKCNFI 320

  Fly   315 ------STTVEVDRGRINQPTLCTNCNTNHCFRLIHNRSEFTDKQLVKLQESPDDMAAGQTPH-- 371
                  |...||      :|..|..|.:...|.:....:.:.:.|.:.:||||..:|||:.|.
Frog   321 LGPFFQSQNQEV------KPGSCPECQSLGPFEINMEETVYQNYQRITIQESPGKVAAGRLPRSK 379

  Fly   372 NVLLYAHNDLVDKVQPGDRVTVTGIYRATPLKTGGLSSSVK-SVYKTHVDVVHFRKVDNKRLYED 435
            :.:|.|  ||||..:|||.:.:||.|...  ..|.|:::.. .|:.|.:...|..|.|:|....:
Frog   380 DAILLA--DLVDSCKPGDEIELTGTYHNN--YDGSLNTANGFPVFATVILANHITKKDDKVAVGE 440

  Fly   436 EEGKDHIFPPERVELLQLLAKKPDIYDRLARAIAPSIYENDDIKKGILLQLFGGTKKKHATLGRQ 500
            ...:|       |:.:..|:|...|.:|:..:||||||.::|||:|:.|.||||..|...  |:.
Frog   441 LTDED-------VKAIVALSKDERIGERIFASIAPSIYGHEDIKRGLALALFGGEAKNPG--GKH 496

  Fly   501 NFRSEIHLLLCGDPGTSKSQMLQYVFNLVPRSQYTSGRGSSAVGLTAYVTKDPETRQLVLQTGAL 565
            ..|.:|::||||||||:|||.|:||..:..|:.:|:|:|:|||||||||.:.|.|::..|:.|||
Frog   497 KVRGDINVLLCGDPGTAKSQFLKYVEKVASRAVFTTGQGASAVGLTAYVQRHPVTKEWTLEAGAL 561

  Fly   566 VLADNGVCCIDEFDKMNDSTRSVLHEVMEQQTLSIAKAGIICQLNARTSILAAANPAESQWNKRK 630
            ||||.|||.|||||||||..|:.:||.||||::||:||||:..|.||.:|:||:||...:::...
Frog   562 VLADRGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTSLQARCTIIAASNPIGGRYDPSL 626

  Fly   631 NIIDNVQLPHTLLSRFDLIFLVLDPQDEIFDKRLASHLVSLYYVTRHE--------EEDTM---- 683
            ...:||.|...::||||::.:|.|..|.:.|:.||..:|. .::..|.        ||..:
Frog   627 TFSENVDLTEPIVSRFDILCVVRDTVDPVQDEMLARFVVG-SHIKHHPSSKDIANGEEFALPNTF 690

  Fly   684 ----FDMSVLRDYIAYAREHLSPTLSDEAQQRLIQAYVDMRKVGAGRGQISAYPRQLESLIRLSE 744
                ....||:.||.|::|.:.|.|:...|.::.:.|.|:||.....|.|....|.:||:||::|
Frog   691 GVEPLPQEVLKKYIMYSKEKIHPKLNQMDQDKVAKMYSDLRKESMATGSIPITVRHIESMIRMAE 755

  Fly   745 AHAKVRLSNQVELLDVEEAWRLHREA 770
            |||::.|.:.|...||..|.|:..|:
Frog   756 AHARMHLRDYVVEDDVNMAIRVMLES 781

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpa	NP_001286160.1	PHA03307	2..>150	CDD:223039	5/21 (24%)
		MCM_N	168..267	CDD:379644	23/99 (23%)
		MCM	270..772	CDD:214631	194/527 (37%)
mcm2	NP_001006772.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..61
		MCM2_N	44..167	CDD:372227	5/23 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	120..151		3/7 (43%)
		MCM_N	184..272	CDD:379644	23/99 (23%)
		MCM	276..783	CDD:214631	194/526 (37%)
		Arginine finger	640..643		2/2 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54431
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.930