DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpa and mcm4

DIOPT Version :9

Sequence 1:	NP_001286160.1	Gene:	dpa / 35679	FlyBaseID:	FBgn0015929	Length:	866	Species:	Drosophila melanogaster
Sequence 2:	NP_001005655.1	Gene:	mcm4 / 448137	XenbaseID:	XB-GENE-1011481	Length:	863	Species:	Xenopus tropicalis

Alignment Length:	879	Identity:	543/879 - (61%)
Similarity:	690/879 - (78%)	Gaps:	31/879 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSSPARSPSVGGATPKQGARTPTRGIASQDVETPMRMGPGRAVRPSDNIS----LP-PTSP-GNI 59
            ||||..:||.......:|:..||.  ..::|::|    |.:..|..|:.|    || |||| |::
Frog     1 MSSPTSTPSRRRNKRGRGSNPPTP--HGEEVQSP----PSQRRRTEDSTSIGELLPMPTSPSGDL 59

  Fly    60 SLPA------TSPARGL-GANMSEIDLSSPLNYGTPSSMGSIRTPRSGIRGTPLRARPDIRTDKR 117
            ..|:      :|||... .|..||:||||||.||||||... .||||||||||.|.|||:.:.::
Frog    60 QSPSGQELMFSSPAPSRHSALQSELDLSSPLTYGTPSSRVE-GTPRSGIRGTPARQRPDLGSARK 123

  Fly   118 IRQVAIGGGSGLEPIPEKGSETTDPVSESSQAPQLVVWGTNVVVSQCKSKFKSFIMRFIDPSAEQ 182
            ::||.:...   :|..|:     ...||.|...:||:|||:|.|:.||.||:.|:.|||||.|::
Frog   124 VKQVDLHSD---QPAAEE-----LVTSEQSLGQKLVIWGTDVNVATCKEKFQRFVQRFIDPLAKE 180

  Fly   183 DEISENIDVNQPLYLQKLEEIHTLEEPYLNLNCAHLKTFDQDLYRQLICYPQEVIPGFDMAINEM 247
            :| :..:|:|:|:|:|:||||:.:.||:||::|.||::|||||||||:||||||||.||||.||:
Frog   181 EE-NVGLDLNEPIYMQRLEEINVVGEPFLNVDCDHLRSFDQDLYRQLVCYPQEVIPTFDMAANEI 244

  Fly   248 FFERYPAALLEHQIQVRPFNADKTRNMRSLNPEDMDQLISISGMVIRSSNVIPEMREAFFSCNIC 312
            ||||||.::|||||||||:||.||||||||||||:||||:|||||||:|.:||||:||||.|.:|
Frog   245 FFERYPDSILEHQIQVRPYNALKTRNMRSLNPEDIDQLITISGMVIRTSQIIPEMQEAFFKCQVC 309

  Fly   313 SFSTTVEVDRGRINQPTLCTNCNTNHCFRLIHNRSEFTDKQLVKLQESPDDMAAGQTPHNVLLYA 377
            :|:|.||:|||||::|::|.:|||.|...||||||.|:|||::||||||:||.||||||..:||.
Frog   310 AFTTRVEIDRGRISEPSVCKHCNTTHSMALIHNRSMFSDKQMIKLQESPEDMPAGQTPHTTILYG 374

  Fly   378 HNDLVDKVQPGDRVTVTGIYRATPLKTGGLSSSVKSVYKTHVDVVHFRKVDNKRLYE-DEEGKDH 441
            ||||||||||||||.|||||||.|::......:||||||||:||:|:||.|.|||:. ||:.:..
Frog   375 HNDLVDKVQPGDRVNVTGIYRAVPIRVNPRVRNVKSVYKTHIDVIHYRKTDAKRLHGIDEDTEQK 439

  Fly   442 IFPPERVELLQLLAKKPDIYDRLARAIAPSIYENDDIKKGILLQLFGGTKKKHATLGRQNFRSEI 506
            :|..|||.:|:.||.|||||:|||.|:||||||::||||||||||||||:|..:..||..||:|:
Frog   440 MFTEERVAMLKELAAKPDIYERLASALAPSIYEHEDIKKGILLQLFGGTRKDFSHTGRGKFRAEV 504

  Fly   507 HLLLCGDPGTSKSQMLQYVFNLVPRSQYTSGRGSSAVGLTAYVTKDPETRQLVLQTGALVLADNG 571
            ::||||||||||||:||||:|||||.|||||:|||||||||||.|||||||||||||||||:|||
Frog   505 NILLCGDPGTSKSQLLQYVYNLVPRGQYTSGKGSSAVGLTAYVMKDPETRQLVLQTGALVLSDNG 569

  Fly   572 VCCIDEFDKMNDSTRSVLHEVMEQQTLSIAKAGIICQLNARTSILAAANPAESQWNKRKNIIDNV 636
            :||||||||||:|||||||||||||||||||||||||||||||:||||||.|||||.:|..|:|:
Frog   570 ICCIDEFDKMNESTRSVLHEVMEQQTLSIAKAGIICQLNARTSVLAAANPVESQWNPKKTTIENI 634

  Fly   637 QLPHTLLSRFDLIFLVLDPQDEIFDKRLASHLVSLYYVTRHEEEDTMFDMSVLRDYIAYAREHLS 701
            |||||||||||||||:||||||.:|:|||.|||:|||.:..:.::...||:||:|||||||.:::
Frog   635 QLPHTLLSRFDLIFLMLDPQDETYDRRLAHHLVALYYQSEEQMKEEHLDMAVLKDYIAYARTYVN 699

  Fly   702 PTLSDEAQQRLIQAYVDMRKVGAGRGQISAYPRQLESLIRLSEAHAKVRLSNQVELLDVEEAWRL 766
            |.|.:||.|.||:|||||||:|:|||.:|||||||||||||||||||||.|::||.:|||||.||
Frog   700 PRLGEEASQALIEAYVDMRKIGSGRGMVSAYPRQLESLIRLSEAHAKVRFSSKVETIDVEEAKRL 764

  Fly   767 HREALKQSATDPLSGKIDVGILTTGLSTAARKKRADLVAAIKENLKKKGKVLTVPYQKLFSDIKE 831
            ||||||||||||.:|.:|:.|||||:|..|||::.:|...:|:.::.|||...:.||:||.|::.
Frog   765 HREALKQSATDPRTGIVDISILTTGMSATARKRKEELAQVLKKLIQSKGKTPALKYQQLFEDLRG 829

  Fly   832 GSQIMITREQFEDALKEVQDEGAIVVMGKNTIRI 865
            .|...:|::.|::||..:.||..:.|.|| |:|:
Frog   830 QSDAAVTKDMFDEALHALADEDYLTVTGK-TVRL 862

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpa	NP_001286160.1	PHA03307	2..>150	CDD:223039	61/160 (38%)
		MCM_N	168..267	CDD:379644	63/98 (64%)
		MCM	270..772	CDD:214631	365/502 (73%)
mcm4	NP_001005655.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..121		55/126 (44%)
		PHA03307	<3..>122	CDD:223039	53/125 (42%)
		MCM_N	166..264	CDD:379644	63/98 (64%)
		MCM	267..770	CDD:214631	365/502 (73%)
		Arginine finger	642..645		2/2 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	369	1.000	Domainoid score	I908
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H40496
Inparanoid	1	1.050	1067	1.000	Inparanoid score	I252
OMA	1	1.010	-	-		QHG54431
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	1	1.000	-	-		FOG0005010
OrthoInspector	1	1.000	-	-		oto102190
Panther	1	1.100	-	-	LDO	PTHR11630
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R694
SonicParanoid	1	1.000	-	-		X3542
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.110