DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpa and MCM7

DIOPT Version :9

Sequence 1:	NP_001286160.1	Gene:	dpa / 35679	FlyBaseID:	FBgn0015929	Length:	866	Species:	Drosophila melanogaster
Sequence 2:	NP_005907.3	Gene:	MCM7 / 4176	HGNCID:	6950	Length:	719	Species:	Homo sapiens

Alignment Length:	736	Identity:	247/736 - (33%)
Similarity:	372/736 - (50%)	Gaps:	91/736 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   165 KSKFKSFIMRF-------------------------------IDPSAEQD-EISENIDVNQPLYL 197
            |.|.|.|:..|                               :|..||.| |:.::|..|...|.
Human    10 KEKVKKFLQEFYQDDELGKKQFKYGNQLVRLAHREQVALYVDLDDVAEDDPELVDSICENARRYA 74

  Fly   198 QKL-EEIHTLEEPYLNLNCAHLKTFDQDLYRQLICYPQEVIPGFDMAINEMFFERYPAALLEH-Q 260
            :.. :.:..|...|......:....|..:..:|:...:...||...:..    .:|||.|:.. :
Human    75 KLFADAVQELLPQYKEREVVNKDVLDVYIEHRLMMEQRSRDPGMVRSPQ----NQYPAELMRRFE 135

  Fly   261 IQVRPFNADKTRNMRSLNPEDMDQLISISGMVIRSSNVIPEMREAFFSCNICSFSTTVEVDRGRI 325
            :..:..:::|.|.:|.:..:.:.:|:::.|:|.|.|.|.|:|..|.::|:.|...|...:.....
Human   136 LYFQGPSSNKPRVIREVRADSVGKLVTVRGIVTRVSEVKPKMVVATYTCDQCGAETYQPIQSPTF 200

  Fly   326 NQPTLCTN--CNTNHC---FRLIHNRSEFTDKQLVKLQESPDDMAAGQTPHNVLLYAHNDLVDKV 385
            ....:|.:  |.||..   ..|....|.|...|.:|:||..|.:..|..|.::.:....:.....
Human   201 MPLIMCPSQECQTNRSGGRLYLQTRGSRFIKFQEMKMQEHSDQVPVGNIPRSITVLVEGENTRIA 265

  Fly   386 QPGDRVTVTGIYRATPLKTGGLSSSVKSVY-KTHVDVVHFRKVDNKRLYEDEEGKDHIFPPERVE 449
            ||||.|:||||:  .|:...|....|:.:. :|:::.....|::...  :||.|...:   .|.|
Human   266 QPGDHVSVTGIF--LPILRTGFRQVVQGLLSETYLEAHRIVKMNKSE--DDESGAGEL---TREE 323

  Fly   450 LLQLLAKKPDIYDRLARAIAPSIYENDDIKKGILLQLFGGTKKKHATLGRQNFRSEIHLLLCGDP 514
            |.|:  .:.|.|::||.:|||.||.::|:||.:||.|.||..:....:   ..|..|::.|.|||
Human   324 LRQI--AEEDFYEKLAASIAPEIYGHEDVKKALLLLLVGGVDQSPRGM---KIRGNINICLMGDP 383

  Fly   515 GTSKSQMLQYVFNLVPRSQYTSGRGSSAVGLTAYVTKDPETRQLVLQTGALVLADNGVCCIDEFD 579
            |.:|||:|.|:..|.||||||:|||||.|||||.|.:|..:.:|.|:.|||||||.|||||||||
Human   384 GVAKSQLLSYIDRLAPRSQYTTGRGSSGVGLTAAVLRDSVSGELTLEGGALVLADQGVCCIDEFD 448

  Fly   580 KMNDSTRSVLHEVMEQQTLSIAKAGIICQLNARTSILAAANPAESQWNKRKNIIDNVQLPHTLLS 644
            ||.::.|:.:||||||||:|||||||:..||||.|||||||||..::|.|:::..|:|||..|||
Human   449 KMAEADRTAIHEVMEQQTISIAKAGILTTLNARCSILAAANPAYGRYNPRRSLEQNIQLPAALLS 513

  Fly   645 RFDLIFLVLDPQDEIFDKRLASHLVSLYYVTRHEEEDTM----FDMSVLRDYIAYAREHLSPTLS 705
            ||||::|:.|..|...|.|||.|:.   ||.:|..:...    .||.::|.|||..||. .|.:.
Human   514 RFDLLWLIQDRPDRDNDLRLAQHIT---YVHQHSRQPPSQFEPLDMKLMRRYIAMCREK-QPMVP 574

  Fly   706 DEAQQRLIQAYVDMRK-VGAGRGQISAYPRQLESLIRLSEAHAKVRLSNQVELLDVEEAWRLHRE 769
            :.....:..|||:||: ..|.:.......|.|.:::|||.|.|::|:.:.||..||.||.|
Human   575 ESLADYITAAYVEMRREAWASKDATYTSARTLLAILRLSTALARLRMVDVVEKEDVNEAIR---- 635

  Fly   770 ALKQSATDPLSGKIDVGILTTGLSTAARKKRADLVAAIKENLKKKGKVLTVPYQKLFSDIKEGSQ 834
             |.:.:.|.|.|  |.|      .||..::.||::.|....|...|:.:.      ||   |..|
Human   636 -LMEMSKDSLLG--DKG------QTARTQRPADVIFATVRELVSGGRSVR------FS---EAEQ 682

  Fly   835 IMITR----EQFEDALKEVQD 851
            ..::|    .||:.||.|.::
Human   683 RCVSRGFTPAQFQAALDEYEE 703

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpa	NP_001286160.1	PHA03307	2..>150	CDD:223039
		MCM_N	168..267	CDD:379644	21/132 (16%)
		MCM	270..772	CDD:214631	201/512 (39%)
MCM7	NP_005907.3	MCM_N	10..93	CDD:405270	15/82 (18%)
		MCM	145..641	CDD:214631	202/516 (39%)
		Arginine finger	513..516		2/2 (100%)
		Interaction with RAD17. /evidence=ECO:0000269\|PubMed:15538388	521..564		14/45 (31%)
		Interaction with ATRIP	577..719		44/149 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820