DRSC/TRiP Functional Genomics Resources

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Protein Alignment dpa and MCM6

DIOPT Version :9

Sequence 1:NP_001286160.1 Gene:dpa / 35679 FlyBaseID:FBgn0015929 Length:866 Species:Drosophila melanogaster
Sequence 2:NP_005906.2 Gene:MCM6 / 4175 HGNCID:6949 Length:821 Species:Homo sapiens


Alignment Length:782 Identity:238/782 - (30%)
Similarity:380/782 - (48%) Gaps:133/782 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly   160 VVSQCKSKFKSFIMRFIDPSAEQDEISENIDVNQPLYLQKLEEIHTLEEPYLNLNCAHLKTFDQD 224
            |..:|:..|..|:..|   .:...||.         |||..||:...|...|.::...|:.|:|.
Human    22 VAEKCQKLFLDFLEEF---QSSDGEIK---------YLQLAEELIRPERNTLVVSFVDLEQFNQQ 74

  Fly   225 LYRQLICYPQEVIPGFDMAINEMFFERYP--AALLEHQIQVR---PFNAD--------KTRN-MR 275
            |               ...|.|.|:..||  ...|:..::.|   |...|        .||: :|
Human    75 L---------------STTIQEEFYRVYPYLCRALKTFVKDRKEIPLAKDFYVAFQDLPTRHKIR 124

  Fly   276 SLNPEDMDQLISISGMVIRSSNVIPEMREAFFSCNICSFSTTVEVDRGRINQPTLCTN--CNTNH 338
            .|....:..|..|||.|:|:..|.||:....|.|..|.........:.:..||.:|.|  |....
Human   125 ELTSSRIGLLTRISGQVVRTHPVHPELVSGTFLCLDCQTVIRDVEQQFKYTQPNICRNPVCANRR 189

  Fly   339 CFRLIHNRSEFTDKQLVKLQESPDDMAAGQTPHNVLLYAHNDLVDKVQPGDRVTVTGIYRATP-- 401
            .|.|..|:|.|.|.|.|::||:..::..|..|.::.:....:.|:..|.||:...||.....|  
Human   190 RFLLDTNKSRFVDFQKVRIQETQAELPRGSIPRSLEVILRAEAVESAQAGDKCDFTGTLIVVPDV 254

  Fly   402 --LKTGG----LSSSVKSV--YKTH---------VDVVHFRKV-------------DNKRLYEDE 436
              |.|.|    .:|.|..|  |:|.         |..:.:|.|             ..|.|.::|
Human   255 SKLSTPGARAETNSRVSGVDGYETEGIRGLRALGVRDLSYRLVFLACCVAPTNPRFGGKELRDEE 319

  Fly   437 EGKDHI---FPPERVELLQLLAKKPDIYDRLARAIAPSIYENDDIKKGILLQLFGGTKKKHATLG 498
            :..:.|   ...:..|.:..:::..::|..|..::.|:|:.||::|:|:||.||||..|   |.|
Human   320 QTAESIKNQMTVKEWEKVFEMSQDKNLYHNLCTSLFPTIHGNDEVKRGVLLMLFGGVPK---TTG 381

  Fly   499 R-QNFRSEIHLLLCGDPGTSKSQMLQYVFNLVPRSQYTSGRGSSAVGLTAYVTKDPETRQLVLQT 562
            . .:.|.:|::.:.|||.|:|||.|::|....||:.||||:.|||.||||.|.:|.|:.:.|::.
Human   382 EGTSLRGDINVCIVGDPSTAKSQFLKHVEEFSPRAVYTSGKASSAAGLTAAVVRDEESHEFVIEA 446

  Fly   563 GALVLADNGVCCIDEFDKMNDSTRSVLHEVMEQQTLSIAKAGIICQLNARTSILAAANPAESQWN 627
            |||:|||||||||||||||:...:..:||.|||||:||.|||:...|||||||||||||....::
Human   447 GALMLADNGVCCIDEFDKMDVRDQVAIHEAMEQQTISITKAGVKATLNARTSILAAANPISGHYD 511

  Fly   628 KRKNIIDNVQLPHTLLSRFDLIFLVLDPQDEIFDKRLASHLVSLYYVTRHEEE-DTMFDMSVLRD 691
            :.|::..|:.|...::|||||.|:::|..:|:.|..:|..:|.|:  :|.||. |.::.:..:|.
Human   512 RSKSLKQNINLSAPIMSRFDLFFILVDECNEVTDYAIARRIVDLH--SRIEESIDRVYSLDDIRR 574

  Fly   692 YIAYAREHLSPTLSDEAQQRLIQAYVDMRK---VGAGRGQISAYPRQLESLIRLSEAHAKVRLSN 753
            |:.:||: ..|.:|.|::..:::.|..:|:   .|..:.......|||||:||||||.|::...:
Human   575 YLLFARQ-FKPKISKESEDFIVEQYKHLRQRDGSGVTKSSWRITVRQLESMIRLSEAMARMHCCD 638

  Fly   754 QVELLDVEEAWRLHREALKQSAT--------DPLSGKIDVGILTTGLSTAARKKRADLVAAI--- 807
            :|:...|:||:||..:::.:..|        :.:..::|.|  ..|::     ..||..|.:   
Human   639 EVQPKHVKEAFRLLNKSIIRVETPDVNLDQEEEIQMEVDEG--AGGIN-----GHADSPAPVNGI 696

  Fly   808 ---KENLKKKGKVLTVPYQKL---FSDIKEGSQIMITR----EQFEDA------------LKEVQ 850
               .|::.::    :.|...|   ||:....|.:::..    |:.||.            |||::
Human   697 NGYNEDINQE----SAPKASLRLGFSEYCRISNLIVLHLRKVEEEEDESALKRSELVNWYLKEIE 757

  Fly   851 DE 852
            .|
Human   758 SE 759

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dpaNP_001286160.1 PHA03307 2..>150 CDD:223039
MCM_N 168..267 CDD:379644 24/103 (23%)
MCM 270..772 CDD:214631 191/544 (35%)
MCM6NP_005906.2 MCM_N 27..114 CDD:405270 25/113 (22%)
MCM 119..657 CDD:214631 191/543 (35%)
Arginine finger 528..531 2/2 (100%)
MCM6_C 713..817 CDD:408078 11/47 (23%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG1241
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D232729at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.820

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