DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpa and MCM5

DIOPT Version :9

Sequence 1:	NP_001286160.1	Gene:	dpa / 35679	FlyBaseID:	FBgn0015929	Length:	866	Species:	Drosophila melanogaster
Sequence 2:	NP_006730.2	Gene:	MCM5 / 4174	HGNCID:	6948	Length:	734	Species:	Homo sapiens

Alignment Length:	731	Identity:	242/731 - (33%)
Similarity:	383/731 - (52%)	Gaps:	91/731 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   162 SQCKSKFKSFIMRFIDPSAEQDEISENIDVNQP----LYLQKLEEIHTLEEPYLNLNCAHLKTFD 222
            ||.:.:||.|:.::            .:..::.    .|..:|:..:.|.|.::.:....|.:||
Human    29 SQLQRRFKEFLRQY------------RVGTDRTGFTFKYRDELKRHYNLGEYWIEVEMEDLASFD 81

  Fly   223 QDLYRQLICYPQEVIPGFDMAINEMFFE----RYPAALLEHQIQVRPFNADKTRNMRSLNPEDMD 283
            :||...|...|.|.:...:.|..|:..|    |.....:...|||...:.....::|||..:.|.
Human    82 EDLADYLYKQPAEHLQLLEEAAKEVADEVTRPRPSGEEVLQDIQVMLKSDASPSSIRSLKSDMMS 146

  Fly   284 QLISISGMVIRSSNVIPEMREAFFSCNICSFSTTVEVDRGRINQPTLCTNCNTNHCFR------- 341
            .|:.|.|::|.:|.|..:.......|..|..:.|....|..:....|...|||:...|
Human   147 HLVKIPGIIIAASAVRAKATRISIQCRSCRNTLTNIAMRPGLEGYALPRKCNTDQAGRPKCPLDP 211

  Fly   342 --LIHNRSEFTDKQLVKLQESPDDMAAGQTPHNVLLYAHNDLVDKVQPGDRVTVTGIYRATPLKT 404
              ::.::.:..|.|.:||||.||.:..|:.|.::.||....|.|||.||:|||:.|||   .:|.
Human   212 YFIMPDKCKCVDFQTLKLQELPDAVPHGEMPRHMQLYCDRYLCDKVVPGNRVTIMGIY---SIKK 273

  Fly   405 GGLSSS---------VKSVYKTHVDVVHFRKVDNKRLYEDEEGKDHIF----PPERVELLQLLAK 456
            .||::|         ::|.|   :.|:        .:..|.:|....|    .|:..|..:.||.
Human   274 FGLTTSRGRDRVGVGIRSSY---IRVL--------GIQVDTDGSGRSFAGAVSPQEEEEFRRLAA 327

  Fly   457 KPDIYDRLARAIAPSIYENDDIKKGILLQLFGGTKKKHAT-LGRQNFRSEIHLLLCGDPGTSKSQ 520
            .|::|:.::::|||||:...|:||.|...||||::|:... |.|   |.:|:||:.|||||:|||
Human   328 LPNVYEVISKSIAPSIFGGTDMKKAIACLLFGGSRKRLPDGLTR---RGDINLLMLGDPGTAKSQ 389

  Fly   521 MLQYVFNLVPRSQYTSGRGSSAVGLTAYVTKDPETRQLVLQTGALVLADNGVCCIDEFDKMNDST 585
            :|::|....|...||||:||||.||||.|.:||.:|..:::.||:||||.||.||||||||.:..
Human   390 LLKFVEKCSPIGVYTSGKGSSAAGLTASVMRDPSSRNFIMEGGAMVLADGGVVCIDEFDKMREDD 454

  Fly   586 RSVLHEVMEQQTLSIAKAGIICQLNARTSILAAANPAESQWNKRKNIIDNVQLPHTLLSRFDLIF 650
            |..:||.|||||:|||||||...||:|.|:|||||....:|::.|. .||:....|:|||||:||
Human   455 RVAIHEAMEQQTISIAKAGITTTLNSRCSVLAAANSVFGRWDETKG-EDNIDFMPTILSRFDMIF 518

  Fly   651 LVLDPQDEIFDKRLASHLVSLYY--VTRHEEEDTMFDMSVLRDYIAYAREHLSPTLSDEAQQRLI 713
            :|.|..:|..|..||.|:::|:.  :|:.:..:...|::.|:.:|||.|....|.||.||.::|.
Human   519 IVKDEHNEERDVMLAKHVITLHVSALTQTQAVEGEIDLAKLKKFIAYCRVKCGPRLSAEAAEKLK 583

  Fly   714 QAYVDMRKVGA--------GRGQISAYPRQLESLIRLSEAHAKVRLSNQVELLDVEEAWRLHREA 770
            ..|:.||. ||        .|..|....||||:::|::||.:|::|.......|||||.||.:.:
Human   584 NRYIIMRS-GARQHERDSDRRSSIPITVRQLEAIVRIAEALSKMKLQPFATEADVEEALRLFQVS 647

  Fly   771 LKQSATDPLSGKIDVGILTTGLSTAARKKRADLVAAIKENLKKKGKVLTVPYQKLFSDIKEGSQI 835
            ...:|   |||.:      :|:.....::..::::.|::.||::..:        .|.:.|.|.|
Human   648 TLDAA---LSGTL------SGVEGFTSQEDQEMLSRIEKQLKRRFAI--------GSQVSEHSII 695

  Fly   836 M-ITREQF-EDALKEV 849
            . .|:::: |.|:.:|
Human   696 KDFTKQKYPEHAIHKV 711

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpa	NP_001286160.1	PHA03307	2..>150	CDD:223039
		MCM_N	168..267	CDD:379644	22/106 (21%)
		MCM	270..772	CDD:214631	202/534 (38%)
MCM5	NP_006730.2	MCM_N	32..129	CDD:405270	22/108 (20%)
MCM5	NP_006730.2	MCM	133..649	CDD:214631	202/534 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820