DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment dpa and MCM2

DIOPT Version :9

Sequence 1:NP_001286160.1 Gene:dpa / 35679 FlyBaseID:FBgn0015929 Length:866 Species:Drosophila melanogaster
Sequence 2:NP_004517.2 Gene:MCM2 / 4171 HGNCID:6944 Length:904 Species:Homo sapiens


Alignment Length:855 Identity:253/855 - (29%)
Similarity:398/855 - (46%) Gaps:167/855 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    19 ARTPTRGIASQDVETPMRMGPGRAVRPSDNISLPPTSPGNISLPATSPARGLGANMSEIDLSSPL 83
            |.:|.:.....|   |:...|||:.|.:|.::   :|||....|....:.||             
Human    11 ASSPAQRRRGND---PLTSSPGRSSRRTDALT---SSPGRDLPPFEDESEGL------------- 56

  Fly    84 NYGTPSSMGSIRTPRSG--IRGTPL----RARPDI------------------------RTDKRI 118
             .||.   |.:.....|  :.|..:    ||.|::                        ..::.:
Human    57 -LGTE---GPLEEEEDGEELIGDGMERDYRAIPELDAYEAEGLALDDEDVEELTASQREAAERAM 117

  Fly   119 RQVAIGGGSGL--------------------------EPIPEKGSETTDPVSESSQAPQLVVWGT 157
            ||.....|.||                          |...|.|.|..:.:........|.....
Human   118 RQRDREAGRGLGRMRRGLLYDSDEEDEERPARKRRQVERATEDGEEDEEMIESIENLEDLKGHSV 182

  Fly   158 NVVVS------QCKSKFKSFIMRFIDPSAE---QDEISENIDVNQPLYLQKLEEIHTLEEPYLNL 213
            ...||      :...:||:|:...:|....   ::.||:....|:...:...|::...|      
Human   183 REWVSMAGPRLEIHHRFKNFLRTHVDSHGHNVFKERISDMCKENRESLVVNYEDLAARE------ 241

  Fly   214 NCAHLKTFDQDLYRQLICY-----PQEVIPGFDMAINEMFFERYPA-ALLEHQIQVRPFNADKTR 272
                          .::.|     |.|::..||.|..|:....||. ..:.:.|.||..:.....
Human   242 --------------HVLAYFLPEAPAELLQIFDEAALEVVLAMYPKYDRITNHIHVRISHLPLVE 292

  Fly   273 NMRSLNPEDMDQLISISGMVIRSSNVIPEMREAFFSCNICSF-------STTVEVDRGRINQPTL 330
            .:|||....::|||..||:|...:.|:|::....::||.|:|       |...||      :|..
Human   293 ELRSLRQLHLNQLIRTSGVVTSCTGVLPQLSMVKYNCNKCNFVLGPFCQSQNQEV------KPGS 351

  Fly   331 CTNCNTNHCFRLIHNRSEFTDKQLVKLQESPDDMAAGQTPH--NVLLYAHNDLVDKVQPGDRVTV 393
            |..|.:...|.:....:.:.:.|.:::||||..:|||:.|.  :.:|.|  ||||..:|||.:.:
Human   352 CPECQSAGPFEVNMEETIYQNYQRIRIQESPGKVAAGRLPRSKDAILLA--DLVDSCKPGDEIEL 414

  Fly   394 TGIYRATPLKTGGLSSSVK-SVYKTHVDVVHFRKVDNKRLYEDEEGKDHIFPPERVELLQLLAKK 457
            ||||...  ..|.|:::.. .|:.|.:...|..|.|||....:...:|       |:::..|:|.
Human   415 TGIYHNN--YDGSLNTANGFPVFATVILANHVAKKDNKVAVGELTDED-------VKMITSLSKD 470

  Fly   458 PDIYDRLARAIAPSIYENDDIKKGILLQLFGGTKKKHATLGRQNFRSEIHLLLCGDPGTSKSQML 522
            ..|.:::..:||||||.::|||:|:.|.||||..|...  |:...|.:|::||||||||:|||.|
Human   471 QQIGEKIFASIAPSIYGHEDIKRGLALALFGGEPKNPG--GKHKVRGDINVLLCGDPGTAKSQFL 533

  Fly   523 QYVFNLVPRSQYTSGRGSSAVGLTAYVTKDPETRQLVLQTGALVLADNGVCCIDEFDKMNDSTRS 587
            :|:..:..|:.:|:|:|:|||||||||.:.|.:|:..|:.|||||||.|||.|||||||||..|:
Human   534 KYIEKVSSRAIFTTGQGASAVGLTAYVQRHPVSREWTLEAGALVLADRGVCLIDEFDKMNDQDRT 598

  Fly   588 VLHEVMEQQTLSIAKAGIICQLNARTSILAAANPAESQWNKRKNIIDNVQLPHTLLSRFDLIFLV 652
            .:||.||||::||:||||:..|.||.:::|||||...:::......:||.|...::||||::.:|
Human   599 SIHEAMEQQSISISKAGIVTSLQARCTVIAAANPIGGRYDPSLTFSENVDLTEPIISRFDILCVV 663

  Fly   653 LDPQDEIFDKRLASHLVSLYYVTRH----EEEDTMFDMS------------------VLRDYIAY 695
            .|..|.:.|:.||..:|..:  .||    :||:.:.:.|                  ||:.||.|
Human   664 RDTVDPVQDEMLARFVVGSH--VRHHPSNKEEEGLANGSAAEPAMPNTYGVEPLPQEVLKKYIIY 726

  Fly   696 AREHLSPTLSDEAQQRLIQAYVDMRKVGAGRGQISAYPRQLESLIRLSEAHAKVRLSNQVELLDV 760
            |:|.:.|.|:...|.::.:.|.|:||.....|.|....|.:||:||::||||::.|.:.|...||
Human   727 AKERVHPKLNQMDQDKVAKMYSDLRKESMATGSIPITVRHIESMIRMAEAHARIHLRDYVIEDDV 791

  Fly   761 EEAWRLHREA 770
            ..|.|:..|:
Human   792 NMAIRVMLES 801

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dpaNP_001286160.1 PHA03307 2..>150 CDD:223039 32/186 (17%)
MCM_N 168..267 CDD:379644 21/107 (20%)
MCM 270..772 CDD:214631 197/533 (37%)
MCM2NP_004517.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..80 20/91 (22%)
Interaction with KAT7. /evidence=ECO:0000250 2..257 47/288 (16%)
MCM2_N 73..182 CDD:403724 14/108 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 109..167 9/57 (16%)
MCM_N 197..286 CDD:405270 21/108 (19%)
MCM 291..803 CDD:214631 197/532 (37%)
Arginine finger 655..658 2/2 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 686..705 4/18 (22%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG1241
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG54431
OrthoDB 1 1.010 - - D232729at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.830

Return to query results.
Submit another query.