Protein Alignment dpa and mcm6

DIOPT Version :10

• Sequence 1: NP_477185.1
• Gene: dpa / 35679
• FlyBaseID: FBgn0015929
• Length: 866
• Species: Drosophila melanogaster
• Sequence 2: NP_989393.1
• Gene: mcm6 / 395030
• XenbaseID: XB-GENE-962678
• Length: 823
• Species: Xenopus tropicalis
• Alignment Length: 801
• Identity: 238/801 - (29%)
• Similarity: 386/801 - (48%)
• Gaps: 148/801 - (18%)

  Fly   138 ETTDPVSESSQAPQLVVWGTNVV---VSQ-CKSKFKSFIMRFIDPSAE---QDEISENI------ 189
            :..|| |:|:.|..    ||..|   ||: |:..|:.|:..|.....|   |.:..|.|
 Frog     2 DLVDP-SQSAAAAA----GTQTVKDEVSEKCQKLFQDFLEEFRGSDGELKYQSDAEELIRPERNT 61

  Fly   190 ---------DVNQPLYLQKLEEIHTLEEPYLNLNCAHLKTFDQDLYRQLICYPQEVIPGFDMAIN 245
                     ..||.|.....||.:.: .|||   |..:|.|.:|...    .||          |
 Frog    62 LLVSFIDLEQFNQQLATTIQEEFYRV-YPYL---CRAVKAFARDHGN----VPQ----------N 108

  Fly   246 EMFFERYPAALLEHQIQVRPFNADKTRNMRSLNPEDMDQLISISGMVIRSSNVIPEMREAFFSCN 310
            :.|:..:......|:|             |.|....:..|:.|||.|:|:..|.||:....|.|.
 Frog   109 KEFYVAFQDLPTRHKI-------------RELTTPRIGSLLRISGQVVRTHPVHPELVSGTFLCL 160

  Fly   311 ICSFSTTVEVDRGRINQPTLCTN--CNTNHCFRLIHNRSEFTDKQLVKLQESPDDMAAGQTPHNV 373
            .|.........:.:..||::|.|  |.....|.|..|:|.|.|.|.|::||:..::..|..|.:|
 Frog   161 DCQTLVRDVEQQFKYTQPSICRNPVCANRRRFMLDTNKSRFVDFQKVRIQETQAELPRGSIPRSV 225

  Fly   374 LLYAHNDLVDKVQPGDRVTVT---------------GIYRATPLKTGGL----SSSVKSVYKTHV 419
            .:....:.|:..|.|||...|               |:...|..:.||.    :..|:.:....|
 Frog   226 EVILRAEAVESCQAGDRCDFTGSLIVVPDISQLATPGVRAETSARVGGTEGYQAEGVQGLRALGV 290

  Fly   420 DVVHFRKV-------------DNKRLYED----EEGKDHIFPPERVELLQLLAKKPDIYDRLARA 467
            ..:.::.|             ..|.|:|:    |..|:.:...|..::.::...| ::|..|..:
 Frog   291 RDLSYKLVFLACYVCPTNPRFGGKDLHEEDMTAESIKNQMSVKEWEKVFEMSQDK-NLYHNLCTS 354

  Fly   468 IAPSIYENDDIKKGILLQLFGGTKKKHATLGRQNFRSEIHLLLCGDPGTSKSQMLQYVFNLVPRS 532
            :.|:::.||::|:||||.||||..|  .|:...:.|.:|::.:.|||.|:|||.|::|....||:
 Frog   355 LFPTVHGNDEVKRGILLMLFGGVPK--TTMEGTSLRGDINVCIVGDPSTAKSQFLKHVEEFSPRA 417

  Fly   533 QYTSGRGSSAVGLTAYVTKDPETRQLVLQTGALVLADNGVCCIDEFDKMNDSTRSVLHEVMEQQT 597
            .||||:.|||.||||.|.||.|:.:.|::.|||:|||||||||||||||:...:..:||.|||||
 Frog   418 VYTSGKASSAAGLTAAVVKDEESHEFVIEAGALMLADNGVCCIDEFDKMDTKDQVAIHEAMEQQT 482

  Fly   598 LSIAKAGIICQLNARTSILAAANPAESQWNKRKNIIDNVQLPHTLLSRFDLIFLVLDPQDEIFDK 662
            :||.|||:...|||||||||||||...::::.|::..|:.|...::|||||.|:::|..:|:.|.
 Frog   483 ISITKAGVKATLNARTSILAAANPVGGRYDRAKSLKQNINLSAPIMSRFDLFFILVDECNEVTDY 547

  Fly   663 RLASHLVSLYYVTRHEEE-DTMFDMSVLRDYIAYAREHLSPTLSDEAQQRLIQAYVDMRK---VG 723
            .:|..:|.|:  :|.||. |.::.:..:|.|:.:||: ..|.:|.|::..:::.|..:|:   .|
 Frog   548 AIARRIVDLH--SRIEESIDRVYTLDEVRRYLLFARQ-FKPKISKESEDFIVEQYKRLRQRDGTG 609

  Fly   724 AGRGQISAYPRQLESLIRLSEAHAKVRLSNQVELLDVEEAWRLHREAL----------------- 771
            ..:.......|||||:|||||..|::..|::|:...|:||:||..:::
 Frog   610 VTKSAWRITVRQLESMIRLSEGMARMHCSDEVQPKHVKEAFRLLNKSIIRVETPDVNLDQEDEHE 674

  Fly   772 -KQSATDPLSGKIDV--GI--LTTGLSTAARKKRADLVAAIKENLKKKGKVLTVPYQKLFSDIKE 831
             ::...:.::|...|  |:  ...|::..|.:..|   |..|.:|:..           |::.|.
 Frog   675 AEEEPQEVINGDASVPSGVNGHVNGMNGHAEEPNA---ATPKPSLRLN-----------FAEYKR 725

  Fly   832 GSQIMITREQFEDALKEVQDE 852
            .|.:::.:      |::::||
 Frog   726 ISNLLVLQ------LRKMEDE 740

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dpa	NP_477185.1	PHA03307	2..>150	CDD:223039	4/11 (36%)
		MCM_N	165..267	CDD:464206	25/119 (21%)
		MCM	270..772	CDD:214631	187/561 (33%)
mcm6	NP_989393.1	MCM_N	28..117	CDD:464206	23/106 (22%)
		MCM	120..658	CDD:475121	189/556 (34%)
		Arginine finger	529..532		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	666..713		7/49 (14%)
		MCM6_C	714..819	CDD:465688	7/44 (16%)