DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpa and Mcm6

DIOPT Version :9

Sequence 1:	NP_001286160.1	Gene:	dpa / 35679	FlyBaseID:	FBgn0015929	Length:	866	Species:	Drosophila melanogaster
Sequence 2:	NP_511065.1	Gene:	Mcm6 / 31603	FlyBaseID:	FBgn0025815	Length:	817	Species:	Drosophila melanogaster

Alignment Length:	757	Identity:	235/757 - (31%)
Similarity:	370/757 - (48%)	Gaps:	96/757 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   173 MRFIDPSAEQDEISENIDVN-QPLYLQKLEEIH------------TLEEP---YLNLNCAHLKTF 221
            |...|....|..:.:.:.:. |.|:...|||..            :||.|   .|.::...::.:
  Fly     1 MDVADAQVGQLRVKDEVGIRAQKLFQDFLEEFKEDGEIKYTRPAASLESPDRCTLEVSFEDVEKY 65

  Fly   222 DQDLYRQLICYPQEVIPGFDMAINEMFFERYP------AALLEHQIQVR-------PFNADKTRN 273
            ||:|               ..||.|.::..||      :..::.:|.::       .|....||:
  Fly    66 DQNL---------------ATAIIEEYYHIYPFLCQSVSNYVKDRIGLKTQKDCYVAFTEVPTRH 115

  Fly   274 -MRSLNPEDMDQLISISGMVIRSSNVIPEMREAFFSCNICSFSTTVEVDRGRINQPTLCTN--CN 335
             :|.|....:..||.|||.|:|:..|.||:....|.|..|.........:.:...||:|.|  |:
  Fly   116 KVRDLTTSKIGTLIRISGQVVRTHPVHPELVSGVFMCLDCQTEIRNVEQQFKFTNPTICRNPVCS 180

  Fly   336 TNHCFRLIHNRSEFTDKQLVKLQESPDDMAAGQTPHNVLLYAHNDLVDKVQPGDRVTVTGIYRAT 400
            ....|.|...:|.|.|.|.:::||:..::..|..|..|.:...::||:.||.|||...||.....
  Fly   181 NRKRFMLDVEKSLFLDFQKIRIQETQAELPRGCIPRAVEIILRSELVETVQAGDRYDFTGTLIVV 245

  Fly   401 P----LKTGGLSSSVKSVYK--------THVDVVHFRKVDNKRLY-------------------- 433
            |    |...|..:...|.:|        |.:..:..|:::.:..:
  Fly   246 PDVSVLAGVGTRAENSSRHKPGEGMDGVTGLKALGMRELNYRMAFLACSVQATTARFGGTDLPMS 310

  Fly   434 --EDEEGKDHIFPPERVELLQLLAKKPDIYDRLARAIAPSIYENDDIKKGILLQLFGGTKKKHAT 496
              ..|:.|..:...|..::.: ::|..::|..|..::.||||.||::|:|||||.|||..|  .|
  Fly   311 EVTAEDMKKQMTDAEWHKIYE-MSKDRNLYQNLISSLFPSIYGNDEVKRGILLQQFGGVAK--TT 372

  Fly   497 LGRQNFRSEIHLLLCGDPGTSKSQMLQYVFNLVPRSQYTSGRGSSAVGLTAYVTKDPETRQLVLQ 561
            ..:.:.|.:|::.:.|||.|:|||.|:.|.:..||:.||||:.|||.||||.|.:|.|:...|::
  Fly   373 TEKTSLRGDINVCIVGDPSTAKSQFLKQVSDFSPRAIYTSGKASSAAGLTAAVVRDEESFDFVIE 437

  Fly   562 TGALVLADNGVCCIDEFDKMNDSTRSVLHEVMEQQTLSIAKAGIICQLNARTSILAAANPAESQW 626
            .|||:|||||:|||||||||:...:..:||.|||||:|||:||:...|||||||||||||...::
  Fly   438 AGALMLADNGICCIDEFDKMDQRDQVAIHEAMEQQTISIARAGVRATLNARTSILAAANPINGRY 502

  Fly   627 NKRKNIIDNVQLPHTLLSRFDLIFLVLDPQDEIFDKRLASHLVSLYYVTRHEEEDTMFDMSVLRD 691
            ::.|::..|:||...::|||||.|:::|..:|:.|..:|..:|.|:.......|.......|||
  Fly   503 DRSKSLQQNIQLSAPIMSRFDLFFILVDECNEVVDYAIARKIVDLHSNIEESVERAYTREEVLR- 566

  Fly   692 YIAYAREHLSPTLSDEAQQRLIQAYVDMRKVGAGRGQISAY---PRQLESLIRLSEAHAKVRLSN 753
            |:.:||: ..|.:|.||...|::.|..:|:...|....|.:   .|||||:||||||.||:..||
  Fly   567 YVTFARQ-FKPVISQEAGHMLVENYGHLRQRDTGTSGRSTWRITVRQLESMIRLSEAMAKLECSN 630

  Fly   754 QVELLDVEEAWRLHREALKQSATDPLSGKIDVGI-LTTGLSTAARKKRADLVAAIKEN----LKK 813
            :|....|:||:||..:::.:.....:....|.|: :..|:......:.....|.:.||    ...
  Fly   631 RVLERHVKEAFRLLNKSIIRVEQPDIHLDDDEGLDMDDGIQHDIDMENNGAAANVDENNGMDTSA 695

  Fly   814 KGKVLTVPYQKLFSDIKEGSQIMITREQFEDALKEVQ--DEG 853
            .|.|....:...|.|.|..|.:::...:.|:|..||:  |.|
  Fly   696 SGAVQKKKFTLSFEDYKNLSTMLVLHMRAEEARCEVEGNDTG 737

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpa	NP_001286160.1	PHA03307	2..>150	CDD:223039
		MCM_N	168..267	CDD:379644	21/122 (17%)
		MCM	270..772	CDD:214631	195/541 (36%)
Mcm6	NP_511065.1	MCM_N	25..109	CDD:379644	16/98 (16%)
		MCM	113..649	CDD:214631	195/540 (36%)
		MCM6_C	702..816	CDD:375690	10/36 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446138
Domainoid	1	1.000	52	1.000	Domainoid score	I661
eggNOG	1	0.900	-	-		E1_COG1241
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D15169at50557
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11630
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.850