DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpa and Mcm2

DIOPT Version :9

Sequence 1:	NP_001286160.1	Gene:	dpa / 35679	FlyBaseID:	FBgn0015929	Length:	866	Species:	Drosophila melanogaster
Sequence 2:	NP_001101343.2	Gene:	Mcm2 / 312538	RGDID:	1305577	Length:	905	Species:	Rattus norvegicus

Alignment Length:	962	Identity:	271/962 - (28%)
Similarity:	436/962 - (45%)	Gaps:	212/962 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SPARSPSVGGATPKQGARTPTRGIASQDVETPMRMGPGRAVRPSDNISLPPTSPGNISLPATSPA 67
            |.|.||:            |.|    :.:..|:...|||:.|.:|.::   :|||....|....:
  Rat     9 SAASSPA------------PQR----RRISDPLTSSPGRSSRRADALT---SSPGRDLPPFEDES 54

  Fly    68 RGLGANMSEIDLSSPLNYGTPSSMGSIRTPRSGIRGTPLRARPDIRTDKRIRQVAIGGGSGLE-- 130
            .||              .||.   |.:.....|              ::.|       |.|:|
  Rat    55 EGL--------------LGTE---GPVEEEEDG--------------EELI-------GDGMERD 81

  Fly   131 --PIPE------KGSETTDPVSESSQAPQL------------------------VVWGTNVVVSQ 163
              ||||      :|....|...|...|.|.                        :::.::....:
  Rat    82 YRPIPELDVYEAEGLALDDEDVEELTASQREAAERAMRQRDREAGRGLGRMRRGLLYDSDEEDEE 146

  Fly   164 CKSKFKSFIMRFIDPSAEQDEISENIDVNQPLYLQKLEEIHTLEEPYL-------NLNCAHLKTF 221
            ..::.:..|.|..:...|.:|:.|:|:..:.|....:.|..::..|.|       |....|:.:.
  Rat   147 RPARKRRHIERATEDGEEDEEMIESIENLEDLKGHSVREWVSMAGPRLEIHHRFKNFLRTHVDSH 211

  Fly   222 DQDLYRQ-------------------------LICY-----PQEVIPGFDMAINEMFFERYPA-A 255
            ..:::::                         ::.|     |.|::..||.|..|:....||. .
  Rat   212 GHNVFKERISDMCKENRESLVVNYEDLAAREHVLAYFLPEAPAELLQIFDEAALEVVLAMYPKYD 276

  Fly   256 LLEHQIQVRPFNADKTRNMRSLNPEDMDQLISISGMVIRSSNVIPEMREAFFSCNICSF------ 314
            .:.:.|.||..:......:|||....::|||..||:|...:.|:|::....::|:.|:|
  Rat   277 RITNHIHVRISHLPLVEELRSLRQLHLNQLIRTSGVVTSCTGVLPQLSMVKYNCSKCNFILGPFC 341

  Fly   315 -STTVEVDRGRINQPTLCTNCNTNHCFRLIHNRSEFTDKQLVKLQESPDDMAAGQTPH--NVLLY 376
             |...||      :|..|..|.:...|.:....:.:.:.|.:::||||..:|||:.|.  :.:|.
  Rat   342 QSQNQEV------KPGSCPECQSTGPFEINMEETIYQNYQRIRIQESPGKVAAGRLPRSKDAILL 400

  Fly   377 AHNDLVDKVQPGDRVTVTGIYRATPLKTGGLSSSVK-SVYKTHVDVVHFRKVDNKRLYEDEEGKD 440
            |  ||||..:|||.:.:||||...  ..|.|:::.. .|:.|.:...|..|.|||....:...:|
  Rat   401 A--DLVDSCKPGDEIELTGIYHNN--YDGSLNTTNGFPVFATIILANHVAKKDNKVAVGELTDED 461

  Fly   441 HIFPPERVELLQLLAKKPDIYDRLARAIAPSIYENDDIKKGILLQLFGGTKKKHATLGRQNFRSE 505
                   |:::..|:|...|.:::..:||||||.::|||:|:.|.||||..|...  |:...|.:
  Rat   462 -------VKMITSLSKDQQIGEKIFASIAPSIYGHEDIKRGLALALFGGEPKNPG--GKHKVRGD 517

  Fly   506 IHLLLCGDPGTSKSQMLQYVFNLVPRSQYTSGRGSSAVGLTAYVTKDPETRQLVLQTGALVLADN 570
            |::||||||||:|||.|:|:..:..|:.:|:|:|:|||||||||.:.|.:|:..|:.|||||||.
  Rat   518 INVLLCGDPGTAKSQFLKYIEKVSSRAIFTTGQGASAVGLTAYVQRHPVSREWTLEAGALVLADR 582

  Fly   571 GVCCIDEFDKMNDSTRSVLHEVMEQQTLSIAKAGIICQLNARTSILAAANPAESQWNKRKNIIDN 635
            |||.|||||||||..|:.:||.||||::||:||||:..|.||.:::|||||...:::......:|
  Rat   583 GVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTSLQARCTVIAAANPIGGRYDPSLTFSEN 647

  Fly   636 VQLPHTLLSRFDLIFLVLDPQDEIFDKRLASHLVSLYYVTRHE--------------EEDTM--- 683
            |.|...::||||::.:|.|..|.:.|:.||..:|..:  .||.              .|..|
  Rat   648 VDLTEPIISRFDVLCVVRDTVDPVQDEMLARFVVGSH--VRHHPSNKKDEGLTNGGTTEPAMPNT 710

  Fly   684 -----FDMSVLRDYIAYAREHLSPTLSDEAQQRLIQAYVDMRKVGAGRGQISAYPRQLESLIRLS 743
                 ....||:.||.||:|.:.|.|:...|.::.:.|.|:||.....|.|....|.:||:||::
  Rat   711 YGVEPLPQEVLKKYIIYAKERVRPKLNQMDQDKVARMYSDLRKESMATGSIPITVRHIESMIRMA 775

  Fly   744 EAHAKVRLSNQVELLDVEEAWRLHREALKQSATDPLSGKIDV---GILTTGLSTAA-----RKKR 800
            ||||::.|.:.|...||..|.|:..|:.           ||.   .::.:...|.|     |:..
  Rat   776 EAHARMHLRDYVMEDDVNMAIRVMLESF-----------IDTQKFSVMRSMRKTFARYLSFRRDN 829

  Fly   801 ADLVAAIKENLKKKGKVLTVPYQKLFSDIKEGSQ---IMITREQFEDALKEV 849
            .||:..|.:.|..:    .|.||:    .:.|:|   |.|..:...|..:::
  Rat   830 NDLLLFILKQLVAE----QVTYQR----NRFGAQQDTIEIPEKDLMDKARQI 873

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpa	NP_001286160.1	PHA03307	2..>150	CDD:223039	33/156 (21%)
		MCM_N	168..267	CDD:379644	24/136 (18%)
		MCM	270..772	CDD:214631	195/533 (37%)
Mcm2	NP_001101343.2	MCM2_N	73..183	CDD:289392	20/116 (17%)
		MCM_N	199..311	CDD:291233	20/111 (18%)
		MCM	292..804	CDD:214631	195/543 (36%)
		P-loop_NTPase	486..>633	CDD:304359	82/148 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54431
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.830