DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpa and Mcm4

DIOPT Version :9

Sequence 1:	NP_001286160.1	Gene:	dpa / 35679	FlyBaseID:	FBgn0015929	Length:	866	Species:	Drosophila melanogaster
Sequence 2:	NP_387500.1	Gene:	Mcm4 / 29728	RGDID:	3060	Length:	862	Species:	Rattus norvegicus

Alignment Length:	879	Identity:	535/879 - (60%)
Similarity:	678/879 - (77%)	Gaps:	32/879 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSSPARSPSVGGATPKQGARTPTRGIASQDVETPMRMGPGRAVRPSDNIS---LP-PTSPG-NIS 60
            |||||.:||  ..:.::|..|||:.:.|::    .|..|....|..|:.:   || ||||| ::.
  Rat     1 MSSPASTPS--RRSSRRGRVTPTQSLRSEE----SRSSPSGRRRGEDSSTGELLPMPTSPGADLQ 59

  Fly    61 LPA-------TSPARGLGANMSEIDLSSPLNYGTPSSMGSIRTPRSGIRGTPLRARPDIRTDKRI 118
            .||       :.|.....|...|.|:||||.||||||... .|||||:||||:|.|||:.:.::.
  Rat    60 SPAAQNALFSSPPQMHSSAIPLEFDVSSPLTYGTPSSRVE-GTPRSGVRGTPMRQRPDLGSARKG 123

  Fly   119 RQVAIGGGSGLEPIPEKGSETTDPV-SESSQAPQLVVWGTNVVVSQCKSKFKSFIMRFIDPSAEQ 182
            .||         .:...|:...|.| ||.|...:||:|||:|.|:.||..|:.|:..|.||.|::
  Rat   124 LQV---------DLQSDGAAAEDTVASEQSLGQKLVIWGTDVNVATCKEHFQRFLQCFTDPLAKE 179

  Fly   183 DEISENIDVNQPLYLQKLEEIHTLEEPYLNLNCAHLKTFDQDLYRQLICYPQEVIPGFDMAINEM 247
            :| :..||:.||||:|:|.||:...||:||:||.|:|:|.::||||||.|||||||.||||:||:
  Rat   180 EE-NVGIDITQPLYMQRLGEINITGEPFLNVNCEHIKSFGKNLYRQLISYPQEVIPTFDMAVNEI 243

  Fly   248 FFERYPAALLEHQIQVRPFNADKTRNMRSLNPEDMDQLISISGMVIRSSNVIPEMREAFFSCNIC 312
            ||:|||.::||||||||||||.||::||:|||||:||||:|||||||:|.:||||:||||.|.:|
  Rat   244 FFDRYPDSILEHQIQVRPFNALKTKSMRNLNPEDIDQLITISGMVIRTSQLIPEMQEAFFQCQVC 308

  Fly   313 SFSTTVEVDRGRINQPTLCTNCNTNHCFRLIHNRSEFTDKQLVKLQESPDDMAAGQTPHNVLLYA 377
            :.:|.||:|||||.:|..|.:|:|.|...||||||.|:|||::||||||:||.||||||.|:|:|
  Rat   309 AHTTRVEMDRGRIAEPCTCVHCHTTHSMALIHNRSLFSDKQMIKLQESPEDMPAGQTPHTVVLFA 373

  Fly   378 HNDLVDKVQPGDRVTVTGIYRATPLKTGGLSSSVKSVYKTHVDVVHFRKVDNKRLYE-DEEGKDH 441
            ||||||||||||||.|||||||.|::.....|:||||||||:||:|:||.|.|||:. |||.:..
  Rat   374 HNDLVDKVQPGDRVNVTGIYRAVPIRVNPRVSNVKSVYKTHIDVIHYRKTDAKRLHGLDEEAEQK 438

  Fly   442 IFPPERVELLQLLAKKPDIYDRLARAIAPSIYENDDIKKGILLQLFGGTKKKHATLGRQNFRSEI 506
            :|..:||:||:.|::|||||:|||.|:||||||::||||||||||||||:|..:..||..||:||
  Rat   439 LFSEKRVKLLKELSRKPDIYERLASALAPSIYEHEDIKKGILLQLFGGTRKDFSHTGRGKFRAEI 503

  Fly   507 HLLLCGDPGTSKSQMLQYVFNLVPRSQYTSGRGSSAVGLTAYVTKDPETRQLVLQTGALVLADNG 571
            ::||||||||||||:||||:|||||.|||||:|||||||||||.|||||||||||||||||:|||
  Rat   504 NILLCGDPGTSKSQLLQYVYNLVPRGQYTSGKGSSAVGLTAYVMKDPETRQLVLQTGALVLSDNG 568

  Fly   572 VCCIDEFDKMNDSTRSVLHEVMEQQTLSIAKAGIICQLNARTSILAAANPAESQWNKRKNIIDNV 636
            :||||||||||:|||||||||||||||||||||||||||||||:||||||.|||||.:|..|:|:
  Rat   569 ICCIDEFDKMNESTRSVLHEVMEQQTLSIAKAGIICQLNARTSVLAAANPIESQWNPKKTTIENI 633

  Fly   637 QLPHTLLSRFDLIFLVLDPQDEIFDKRLASHLVSLYYVTRHEEEDTMFDMSVLRDYIAYAREHLS 701
            |||||||||||||||:||||||.:|:|||.|||||||.:..:.|....||:||:||||||...:.
  Rat   634 QLPHTLLSRFDLIFLMLDPQDEAYDRRLAHHLVSLYYQSEEQVEQEFLDMAVLKDYIAYAHSTIM 698

  Fly   702 PTLSDEAQQRLIQAYVDMRKVGAGRGQISAYPRQLESLIRLSEAHAKVRLSNQVELLDVEEAWRL 766
            |.||:||.|.||:|||:|||:|:.||.:|||||||||||||:|||||||.|::||.:|||||.||
  Rat   699 PRLSEEASQALIEAYVNMRKIGSSRGMVSAYPRQLESLIRLAEAHAKVRFSDKVEAIDVEEAKRL 763

  Fly   767 HREALKQSATDPLSGKIDVGILTTGLSTAARKKRADLVAAIKENLKKKGKVLTVPYQKLFSDIKE 831
            ||||||||||||.:|.:|:.|||||:|..:||::.:|..|:::.:..|||...:.||:||.||:.
  Rat   764 HREALKQSATDPRTGIVDISILTTGMSATSRKRKEELAEALRKLILSKGKTPALKYQQLFEDIRG 828

  Fly   832 GSQIMITREQFEDALKEVQDEGAIVVMGKNTIRI 865
            .|...||::.||:||:.:.|:..:.|.|| |:|:
  Rat   829 QSDTAITKDMFEEALRALADDDFLTVTGK-TVRL 861

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpa	NP_001286160.1	PHA03307	2..>150	CDD:223039	59/160 (37%)
		MCM_N	168..267	CDD:379644	59/98 (60%)
		MCM	270..772	CDD:214631	362/502 (72%)
Mcm4	NP_387500.1	MCM_N	165..286	CDD:291233	76/121 (63%)
		MCM	266..769	CDD:214631	362/502 (72%)
		P-loop_NTPase	504..643	CDD:304359	120/138 (87%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166341375
Domainoid	1	1.000	371	1.000	Domainoid score	I865
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H40496
Inparanoid	1	1.050	1040	1.000	Inparanoid score	I249
OMA	1	1.010	-	-		QHG54431
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	1	1.000	-	-		FOG0005010
OrthoInspector	1	1.000	-	-		oto95449
orthoMCL	1	0.900	-	-		OOG6_101805
Panther	1	1.100	-	-	LDO	PTHR11630
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3542
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770