DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpa and Mcm6

DIOPT Version :9

Sequence 1:	NP_001286160.1	Gene:	dpa / 35679	FlyBaseID:	FBgn0015929	Length:	866	Species:	Drosophila melanogaster
Sequence 2:	NP_058983.1	Gene:	Mcm6 / 29685	RGDID:	61967	Length:	821	Species:	Rattus norvegicus

Alignment Length:	784	Identity:	243/784 - (30%)
Similarity:	386/784 - (49%)	Gaps:	128/784 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   147 SQAPQLVVWGTNVVVSQCKSKFKSFIMRFIDPSAEQDEISENIDVNQPLYLQKLEEIHTLEEPYL 211
            ||.|::    .:.|..:|:..|..|:..|   .....||.         |||..||:...|...|
  Rat    13 SQHPEV----RDEVAEKCQKLFLDFLEEF---QGSDGEIK---------YLQFAEELIRPERNTL 61

  Fly   212 NLNCAHLKTFDQDLYRQLICYPQEVIPGFDMAINEMFFERYP--AALLEHQIQVR---PFNAD-- 269
            .::.|.|:.|:|.|               ...|.|.|:..||  ...|:..::.|   ||..|
  Rat    62 VVSFADLEQFNQQL---------------STTIQEEFYRVYPYLCRALKTFVKDRKEIPFAKDFY 111

  Fly   270 ------KTRN-MRSLNPEDMDQLISISGMVIRSSNVIPEMREAFFSCNICSFSTTVEVD---RGR 324
                  .||: :|.|....:..|..|||.|:|:..|.||:....|.|..|.   ||..|   :.:
  Rat   112 VAFQDLPTRHKIRELTSSRIGLLTRISGQVVRTHPVHPELVSGTFLCLDCQ---TVIKDVEQQFK 173

  Fly   325 INQPTLCTN--CNTNHCFRLIHNRSEFTDKQLVKLQESPDDMAAGQTPHNVLLYAHNDLVDKVQP 387
            ..||::|.|  |.....|.|..|:|.|.|.|.|::||:..::..|..|.::.:....:.|:..|.
  Rat   174 YTQPSICRNPVCANRKRFLLDTNKSRFVDFQKVRIQETQAELPRGSIPRSLEVVLRAEAVESAQA 238

  Fly   388 GDRVTVTGIYRATP----LKTGGLSSSVKS------VYKTH---------VDVVHFRKV------ 427
            |||...||.....|    |.|.|..:...|      .|:|.         |..:.:|.|
  Rat   239 GDRCDFTGTLIVVPDVSKLSTPGARAETNSRVSGADGYETEGIRGLRALGVRDLSYRLVFLACYV 303

  Fly   428 -------DNKRLYEDEEGKDHI---FPPERVELLQLLAKKPDIYDRLARAIAPSIYENDDIKKGI 482
                   ..|.|.::|:..:.|   ...:..|.:..:::..::|..|..::.|:|:.||::|:|:
  Rat   304 APTNPRFGGKELRDEEQTAESIKNQMTVKEWEKVFEMSQDKNLYHNLCTSLFPTIHGNDEVKRGV 368

  Fly   483 LLQLFGGTKKKHATLGR-QNFRSEIHLLLCGDPGTSKSQMLQYVFNLVPRSQYTSGRGSSAVGLT 546
            ||.||||..|   |.|. .:.|.:|::.:.|||.|:|||.|::|....||:.||||:.|||.|||
  Rat   369 LLMLFGGVPK---TTGEGTSLRGDINVCIVGDPSTAKSQFLKHVDEFSPRAVYTSGKASSAAGLT 430

  Fly   547 AYVTKDPETRQLVLQTGALVLADNGVCCIDEFDKMNDSTRSVLHEVMEQQTLSIAKAGIICQLNA 611
            |.|.:|.|:.:.|::.|||:|||||||||||||||:...:..:||.|||||:||.|||:...|||
  Rat   431 AAVVRDEESHEFVIEAGALMLADNGVCCIDEFDKMDMRDQVAIHEAMEQQTISITKAGVKATLNA 495

  Fly   612 RTSILAAANPAESQWNKRKNIIDNVQLPHTLLSRFDLIFLVLDPQDEIFDKRLASHLVSLYYVTR 676
            ||||||||||....:::.|::..|:.|...::|||||.|:::|..:|:.|..:|..:|.|:  :|
  Rat   496 RTSILAAANPVSGHYDRSKSLKQNINLSAPIMSRFDLFFILVDECNEVTDYAIARRIVDLH--SR 558

  Fly   677 HEEE-DTMFDMSVLRDYIAYAREHLSPTLSDEAQQRLIQAYVDMR-KVGAG--RGQISAYPRQLE 737
            .||. |.::.:..:|.|:.:||: ..|.:|.|::..:::.|..:| :.|:|  :.......||||
  Rat   559 IEESIDRVYSLDDIRRYLLFARQ-FKPKISKESEDFIVEQYKRLRQRDGSGITKSSWRITVRQLE 622

  Fly   738 SLIRLSEAHAKVRLSNQVELLDVEEAWRLHREALKQSATDPLSGKIDVGI-------LTTGLSTA 795
            |:|||||:.|::...::|:...|:||:||..:::.:..|.      ||.:       :.|.....
  Rat   623 SMIRLSESMARMHCCDEVQPKHVKEAFRLLNKSIIRVETP------DVNLDQEEEIQMETDEGPG 681

  Fly   796 ARKKRADLVAAIK------ENLKKKGKVLTVPYQKL---FSDIKEGSQIMITREQFEDALKEVQD 851
            .....||..|.:.      |:..::    |||...|   |::....|.:::...:   .::|.:|
  Rat   682 GINGHADSPAPVNGFNGSGEDASQE----TVPKPSLRLGFAEYCRISNLIVLHLR---KMEEEED 739

  Fly   852 EGAI 855
            |.|:
  Rat   740 ESAL 743

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpa	NP_001286160.1	PHA03307	2..>150	CDD:223039	2/2 (100%)
		MCM_N	168..267	CDD:379644	25/103 (24%)
		MCM	270..772	CDD:214631	193/547 (35%)
Mcm6	NP_058983.1	MCM_N	27..114	CDD:405270	27/113 (24%)
		MCM	119..657	CDD:214631	193/546 (35%)
		MCM6_C	711..817	CDD:408078	7/36 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820