DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpa and Mcm7

DIOPT Version :9

Sequence 1:	NP_001286160.1	Gene:	dpa / 35679	FlyBaseID:	FBgn0015929	Length:	866	Species:	Drosophila melanogaster
Sequence 2:	NP_001004203.3	Gene:	Mcm7 / 288532	RGDID:	1303018	Length:	719	Species:	Rattus norvegicus

Alignment Length:	757	Identity:	247/757 - (32%)
Similarity:	386/757 - (50%)	Gaps:	110/757 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   165 KSKFKSFIMRF----------------IDPSAEQDEISENIDVNQPLYLQKLEEIHTLEEPYLNL 213
            |.|.|.|:..|                :...|.:::::..:|         |:::...:...::.
  Rat    10 KEKVKKFLQEFYYDDELGKKQFKYGTQLVHLAHREQVALYVD---------LDDVAEDDPELVDS 65

  Fly   214 NCAHLKTFDQDLYRQLICYPQEVIPGF------DMAINEMFFE--------------------RY 252
            .|.:.|.:.: |:..::   ||::|.:      :..:.:::.|                    :|
  Rat    66 ICENAKRYSR-LFADVV---QELLPEYKEKEVVNKDVLDVYIEHRLMMEQRSRDPGAVRNPQNQY 126

  Fly   253 PAALLEH-QIQVRPFNADKTRNMRSLNPEDMDQLISISGMVIRSSNVIPEMREAFFSCNICSFST 316
            |:.|:.. ::..:..::.|.|.:|.:..:.:.:|:::.|:|.|.|.|.|.|..|.::|:.|...|
  Rat   127 PSELMRRFELYFQGPSSSKPRVIREVRADSVGKLLTVRGIVTRVSEVKPRMVVATYTCDQCGAET 191

  Fly   317 TVEVDRGRINQPTLCTN--CNTNHC---FRLIHNRSEFTDKQLVKLQESPDDMAAGQTPHNVLLY 376
            ...:.........:|.:  |.||..   ..|....|:|...|.:|:||..|.:..|..|.::.:.
  Rat   192 YQPIQSPTFMPLIMCPSQECQTNRSGGRLYLQTRGSKFIKFQEMKIQEHSDQVPVGNIPRSITVV 256

  Fly   377 AHNDLVDKVQPGDRVTVTGIYRATPLKTGGLSSSVKSVYKTHVDVVHFRKVDNKRLYEDEEGKDH 441
            ...:.....||||.|:||||:... |:||....:...:.:|:::.  .|.|...:..:|..|...
  Rat   257 LEGENTRIAQPGDHVSVTGIFLPV-LRTGFQQMAQGLLSETYLEA--HRVVKMTKSEDDVSGAGE 318

  Fly   442 IFPPERVELLQLLAKKPDIYDRLARAIAPSIYENDDIKKGILLQLFGGTKKKHATLGRQNFRSEI 506
            :    ..|.|:.:|:: |.|::||.:|||.||.::|:||.:||.|.||..:....:   ..|..|
  Rat   319 L----SAEELKQIAEE-DFYEKLAASIAPEIYGHEDVKKALLLLLVGGVDQSPQGM---KIRGNI 375

  Fly   507 HLLLCGDPGTSKSQMLQYVFNLVPRSQYTSGRGSSAVGLTAYVTKDPETRQLVLQTGALVLADNG 571
            |:.|.||||.:|||:|.|:..|.||||||:|||||.|||||.|.:|..:.:|.|:.|||||||.|
  Rat   376 HICLMGDPGVAKSQLLSYIDRLAPRSQYTTGRGSSGVGLTAAVLRDSVSGELTLEGGALVLADQG 440

  Fly   572 VCCIDEFDKMNDSTRSVLHEVMEQQTLSIAKAGIICQLNARTSILAAANPAESQWNKRKNIIDNV 636
            ||||||||||.::.|:.:||||||||:|||||||:..||||.|||||||||..::|.|:::..|:
  Rat   441 VCCIDEFDKMAEADRTAIHEVMEQQTISIAKAGILTTLNARCSILAAANPAYGRYNPRRSLEQNI 505

  Fly   637 QLPHTLLSRFDLIFLVLDPQDEIFDKRLASHLVSLYYVTRHEEEDTM----FDMSVLRDYIAYAR 697
            |||..|||||||::|:.|..|...|.|||.|:.   ||.:|..:...    .||.::|.|||..|
  Rat   506 QLPAALLSRFDLLWLIQDRPDRDNDLRLAQHIT---YVHQHSRQPPAQFEPLDMKLMRRYIAMCR 567

  Fly   698 EHLSPTLSDEAQQRLIQAYVDMRK-VGAGRGQISAYPRQLESLIRLSEAHAKVRLSNQVELLDVE 761
            |. .||:.|.....:..|||:||: ..|.:.......|.|.:::|||.|.|::|:.:.||..||.
  Rat   568 ER-QPTVPDSLADYITAAYVEMRREARASKDATYTSARTLLAILRLSTALARLRMVDIVEKEDVN 631

  Fly   762 EAWRLHREALKQSATDPLSGKIDVGILTTGLSTAARKKRADLVAAIKENLKKKGKVLTVPYQKLF 826
            ||.|     |.:.:.|.|.|:..        .||..::.||::.|....|...|:.:.      |
  Rat   632 EAIR-----LMEMSKDSLLGEKG--------QTARTQRPADVIFATVRELVSGGRSVR------F 677

  Fly   827 SDIKEGSQIMITR----EQFEDALKEVQDEGAIVVMGKNTIR 864
            |   |..|..|:|    .||:.||.|.::   :.|...||.|
  Rat   678 S---EAEQRCISRGFTPAQFQAALDEYEE---LNVWQVNTSR 713

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpa	NP_001286160.1	PHA03307	2..>150	CDD:223039
		MCM_N	168..267	CDD:379644	16/141 (11%)
		MCM	270..772	CDD:214631	203/511 (40%)
Mcm7	NP_001004203.3	MCM_N	12..165	CDD:291233	21/165 (13%)
		MCM	145..641	CDD:214631	204/515 (40%)
		P-loop_NTPase	376..515	CDD:304359	88/138 (64%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820