DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpa and MCM9

DIOPT Version :9

Sequence 1:	NP_001286160.1	Gene:	dpa / 35679	FlyBaseID:	FBgn0015929	Length:	866	Species:	Drosophila melanogaster
Sequence 2:	NP_001365285.1	Gene:	MCM9 / 254394	HGNCID:	21484	Length:	1143	Species:	Homo sapiens

Alignment Length:	628	Identity:	195/628 - (31%)
Similarity:	305/628 - (48%)	Gaps:	115/628 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   181 EQDEISENIDVNQPLYLQKLEEIHTLEE--PYLNLNCAHLKTFDQDLYRQLICYPQEVIPGFDMA 243
            |:||     |.:.|:.:..:....|..|  .|.|:                  :|.||:..||.|
Human    31 ERDE-----DAHYPVVVNAMTLFETNMEIGEYFNM------------------FPSEVLTIFDSA 72

  Fly   244 INEMFFERYPAALLEHQIQVRPFNADKTRNMRS------LNPE----------DMDQLISISGMV 292
            :..       :||...|...:|......:|:.:      :.||          |:...:|::|.|
Human    73 LRR-------SALTILQSLSQPEAVSMKQNLHARISGLPVCPELVREHIPKTKDVGHFLSVTGTV 130

  Fly   293 IRSSNVIPEMREAFFSCNICSFSTTVEVDRGRINQPTLCTNCNTNHCFRLIH-NRSEFT------ 350
            ||:|.|.....|..:.||.|.....::.|..:     ..|.|..:.|..|.. :.|:||
Human   131 IRTSLVKVLEFERDYMCNKCKHVFVIKADFEQ-----YYTFCRPSSCPSLESCDSSKFTCLSGLS 190

  Fly   351 -------DKQLVKLQESPDDMAAGQTPHNVLLYAHNDLVDKVQPGDRVTVTGI--YRATPLKTGG 406
                   |.|.:|:||....::.|..|.::.:...:||||..:.||.:|:.||  .|..|.:. .
Human   191 SSPTRCRDYQEIKIQEQVQRLSVGSIPRSMKVILEDDLVDSCKSGDDLTIYGIVMQRWKPFQQ-D 254

  Fly   407 LSSSVKSVYKTHVDVVHFRKVDN------------KRLYED--EEGKDHIFPPERVELLQLLAKK 457
            :...|:.|.|     .::.:|:|            ::.:||  |..|...|....|.|..|
Human   255 VRCEVEIVLK-----ANYIQVNNEQSSGIIMDEEVQKEFEDFWEYYKSDPFAGRNVILASL---- 310

  Fly   458 PDIYDRLARAIAPSIYENDDIKKGILLQLFGGTKKKHATLGRQNFRSEIHLLLCGDPGTSKSQML 522
                       .|.::....:|..:.:.|.||.::..||..|  .|.|.||||.|||||.|||.|
Human   311 -----------CPQVFGMYLVKLAVAMVLAGGIQRTDATGTR--VRGESHLLLVGDPGTGKSQFL 362

  Fly   523 QYVFNLVPRSQYTSGRGSSAVGLTAYVTKDPETRQLVLQTGALVLADNGVCCIDEFDKMNDSTRS 587
            :|...:.|||..|:|.||::.|||....||  :.:..|:.|||||||.|:||||||:.:.:..|:
Human   363 KYAAKITPRSVLTTGIGSTSAGLTVTAVKD--SGEWNLEAGALVLADAGLCCIDEFNSLKEHDRT 425

  Fly   588 VLHEVMEQQTLSIAKAGIICQLNARTSILAAANPAESQWNKRKNIIDNVQLPHTLLSRFDLIFLV 652
            .:||.|||||:|:||||::|:||.||:||||.|| :.|::.::::..|:.|...||||||||.::
Human   426 SIHEAMEQQTISVAKAGLVCKLNTRTTILAATNP-KGQYDPQESVSVNIALGSPLLSRFDLILVL 489

  Fly   653 LDPQDEIFDKRLASHLV-SLYYVTRHEEEDTMFDMSVLRDYIAYAREHLSPTLSDEAQQRLIQAY 716
            ||.::|.:|:.::|.:: :..|.::.|:   ::.|..::.|....| :|.|||||...|.|:: |
Human   490 LDTKNEDWDRIISSFILENKGYPSKSEK---LWSMEKMKTYFCLIR-NLQPTLSDVGNQVLLR-Y 549

  Fly   717 VDMRKVGAGRGQISAYPRQLESLIRLSEAHAKVRLSNQVELLD 759
            ..|::....|.......|.|||||||:||||::...:.|.|.|
Human   550 YQMQRQSDCRNAARTTIRLLESLIRLAEAHARLMFRDTVTLED 592

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpa	NP_001286160.1	PHA03307	2..>150	CDD:223039
		MCM_N	168..267	CDD:379644	19/87 (22%)
		MCM	270..772	CDD:214631	176/537 (33%)
MCM9	NP_001365285.1	MCM_OB	116..243	CDD:407328	34/131 (26%)
		MCM9	305..603	CDD:350666	125/313 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	656..738
		PTZ00449	<751..1113	CDD:185628
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	755..815
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	868..916
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	942..1011
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1063..1105
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820