Protein Alignment dpa and mcm4

DIOPT Version :10

• Sequence 1: NP_477185.1
• Gene: dpa / 35679
• FlyBaseID: FBgn0015929
• Length: 866
• Species: Drosophila melanogaster
• Sequence 2: NP_588004.2
• Gene: mcm4 / 2539164
• PomBaseID: SPCC16A11.17
• Length: 911
• Species: Schizosaccharomyces pombe
• Alignment Length: 919
• Identity: 383/919 - (41%)
• Similarity: 537/919 - (58%)
• Gaps: 101/919 - (10%)

  Fly    20 RTPTRGIASQDVETPMRMGPGRAVRPSDNISLPPTSPGN--ISLPATSPARGLGANMSEIDLSSP 82
            |||.|..:|           .|....|..:..|.:|||:  ::.|.|:....|.::....:.|||
pombe    14 RTPGRANSS-----------SREAVDSSPLFFPASSPGSTRLTTPRTTARTPLASSPLLFESSSP 67

  Fly    83 LNYGTPSS---------------MGSIRTPRSGIRG---------TPLR------ARPDIRTDKR 117
             ....|.|               ..|.|||||..||         ||.|      .||.:.|..
pombe    68 -GPNIPQSSRSHLLSQRNDLFLDSSSQRTPRSTRRGDIHSSVQMSTPSRRREVDPQRPGVSTPS- 130

  Fly   118 IRQVAIGGGSGLEPIPEKGSETTDPVSESSQAPQLVVWGTNVVVSQCKSKFKSFIMRFIDPSAEQ 182
              .:...|...|.      .....|.||.:.....|:|||||.:.:..:.|:.|:..|......:
pombe   131 --SLLFSGSDALT------FSQAHPSSEVADDTVRVIWGTNVSIQESIASFRGFLRGFKKKYRPE 187

  Fly   183 --DEISENIDVNQPLYLQKLEEIHTLEEPYLNLNCAHLKTF--DQDLYRQLICYPQEVIPGFDMA 243
              :|:....|..|.:|::.|..:..:....|||:...||.:  .:.||.||..||||:||..|..
pombe   188 YRNELMPPPDAEQLVYIEALRNMRIMGLEILNLDVQDLKHYPPTKKLYHQLYSYPQEIIPIMDQT 252

  Fly   244 INEMFFE----RYPAALL---EHQI-QVRPFNADKTRNMRSLNPEDMDQLISISGMVIRSSNVIP 300
            |.::..:    ..|..:|   |.:| ::||||.:|..|||.|||.|:|:||||.|:|:|.:.|||
pombe   253 IKDVMLDLLGTNPPEDVLNDIELKIYKIRPFNLEKCINMRDLNPGDIDKLISIKGLVLRCTPVIP 317

  Fly   301 EMREAFFSCNICSFSTTVEVDRGRINQPTLCTN--CNTNHCFRLIHNRSEFTDKQLVKLQESPDD 363
            :|::|||.|::|....|||:|||||.:|..|..  |...:..:||||||||.|||::||||:||.
pombe   318 DMKQAFFRCSVCGHCVTVEIDRGRIAEPIKCPREVCGATNAMQLIHNRSEFADKQVIKLQETPDV 382

  Fly   364 MAAGQTPHNVLLYAHNDLVDKVQPGDRVTVTGIYRATPLKTGGLSSSVKSVYKTHVDVVHFRKVD 428
            :..|||||:|.|..:::|||..:.|||:.||||:|..|::......:|||::||:|||||.:|.|
pombe   383 VPDGQTPHSVSLCVYDELVDSARAGDRIEVTGIFRCVPVRLNPRMRTVKSLFKTYVDVVHIKKQD 447

  Fly   429 NKRLYED---------EEGKDHI-----FPPERVELLQLLAKKPDIYDRLARAIAPSIYENDDIK 479
            .:||..|         |:....|     ...|.||.:|.::|:.||||.|:|::||||||.||:|
pombe   448 KRRLGTDPSTLESDIAEDAALQIDEVRKISDEEVEKIQQVSKRDDIYDILSRSLAPSIYEMDDVK 512

  Fly   480 KGILLQLFGGTKKKHATLGRQNFRSEIHLLLCGDPGTSKSQMLQYVFNLVPRSQYTSGRGSSAVG 544
            ||:||||||||.|.........:|.:|::|:||||.|||||:|:||..:.||..||||:||||||
pombe   513 KGLLLQLFGGTNKSFHKGASPRYRGDINILMCGDPSTSKSQILKYVHKIAPRGVYTSGKGSSAVG 577

  Fly   545 LTAYVTKDPETRQLVLQTGALVLADNGVCCIDEFDKMNDSTRSVLHEVMEQQTLSIAKAGIICQL 609
            ||||:|:|.:|:||||::|||||:|.|:|||||||||:|:|||:|||||||||:::||||||..|
pombe   578 LTAYITRDQDTKQLVLESGALVLSDGGICCIDEFDKMSDATRSILHEVMEQQTVTVAKAGIITTL 642

  Fly   610 NARTSILAAANPAESQWNKRKNIIDNVQLPHTLLSRFDLIFLVLDPQDEIFDKRLASHLVSLYY- 673
            ||||||||:|||..|::|....:..|:.||.||||||||::|:||..||..|::||:|:||:|.
pombe   643 NARTSILASANPIGSKYNPDLPVTKNIDLPPTLLSRFDLVYLILDRVDETLDRKLANHIVSMYME 707

  Fly   674 -VTRHEEEDTMFDMSVLRDYIAYAREHLSPTLSDEAQQRLIQAYVDMRKVG----AGRGQISAYP 733
             ...|..:..:|.:..|..||.|||.:::|.:|:||.:.|:.|||.|||:|    |...:|:|..
pombe   708 DTPEHATDMEVFSVEFLTSYITYARNNINPVISEEAAKELVNAYVGMRKLGEDVRASEKRITATT 772

  Fly   734 RQLESLIRLSEAHAKVRLSNQVELLDVEEAWRLHREALKQSATDPLSGKIDVGIL-----TTGLS 793
            |||||:|||||||||:.|.|.||:.||.||.||.:.|:|..||||.:|||.:.::     .|.:.
pombe   773 RQLESMIRLSEAHAKMHLRNVVEVGDVLEAARLIKTAIKDYATDPATGKISLDLIYVNERETLVP 837

  Fly   794 TAARKKRADLVAAIKENLKKKGKVLTVPYQKLFSDIKEGSQIMITREQFEDALKEVQDEGAIVVM 858
            ....|:.|:|::    ||...||.:.|  .:|.:..:|.|...:....||..|..::..|.|.|:
pombe   838 EDMVKELANLIS----NLTVGGKTMLV--SQLLTRFREQSSTRLDASDFEACLGALERRGRIKVI 896

  Fly   859 ---GKNTIR 864
               |...:|
pombe   897 TSAGHRIVR 905

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dpa	NP_477185.1	PHA03307	2..>150	CDD:223039	38/161 (24%)
		MCM_N	165..267	CDD:464206	31/113 (27%)
		MCM	270..772	CDD:214631	278/523 (53%)
mcm4	NP_588004.2	MCM_N	173..284	CDD:464206	31/110 (28%)
		MCM	287..811	CDD:214631	278/523 (53%)