Protein Alignment dpa and mcm2

DIOPT Version :10

• Sequence 1: NP_477185.1
• Gene: dpa / 35679
• FlyBaseID: FBgn0015929
• Length: 866
• Species: Drosophila melanogaster
• Sequence 2: NP_775364.2
• Gene: mcm2 / 192338
• ZFINID: ZDB-GENE-020419-24
• Length: 889
• Species: Danio rerio
• Alignment Length: 921
• Identity: 277/921 - (30%)
• Similarity: 433/921 - (47%)
• Gaps: 165/921 - (17%)

  Fly    19 ARTPTRGIASQDVETPMRMGPGRAVRPSDNIS---LPPTSPGNIS-----------------LPA 63
            |.:||||....|:.:    .|||.:.|.::.|   |..|.|....                 :|.
Zfish    11 ATSPTRGSRRGDLTS----SPGRDLPPFEDESEGLLGDTLPDEEDDDGEELIGDAMERDYRVIPE 71

  Fly    64 TSPARGLGANMSEIDLS--SPLNYGTPSSMGSIRTPRSGI------RGT--PLRARPDIRTDKRI 118
            .......|.:..| |||  ||.......:....|....|:      ||.  ......|.|..||.
Zfish    72 LDRYEAEGLDEDE-DLSELSPSARAEAEAAMRRRDREQGLGMGRIGRGLLYDSEDEDDKRPTKRQ 135

  Fly   119 RQVA--IGGGSGLEPIPEKGSETTDPVSE----------SSQAPQLVVWGTNVVVSQCKSKFKSF 171
            |.:|  ...|..:|...|:..|:.:.:.:          |..||:|.::          .:||:|
Zfish   136 RVLAERAAEGGAMEGEDEEMIESIENLEDMKGHTVREWVSMAAPRLEIY----------HRFKNF 190

  Fly   172 IMRFIDPSAE---QDEISENIDVNQPLYLQKLEEIHTLEEPYLNLNCAHLKTFDQDLYRQLICY- 232
            :...:|....   ::.||:....|:...|...||:.:.|                    .::.|
Zfish   191 LRTHVDEHGHNVFKERISDMCKENKESLLVNYEELASRE--------------------HVLAYF 235

  Fly   233 ----PQEVIPGFDMAINEMFFERYPA-ALLEHQIQVRPFNADKTRNMRSLNPEDMDQLISISGMV 292
                |.|::..||.|..|:....||. ..:.|:|.||..|......:|||....::|||..||:|
Zfish   236 LPEAPAEMLKIFDEAAKEVVLAMYPKYDRIAHEIHVRIGNLPLVEELRSLRQLHLNQLIRTSGVV 300

  Fly   293 IRSSNVIPEMREAFFSCNICSF-------STTVEVDRGRINQPTLCTNCNTNHCFRLIHNRSEFT 350
            ...:.|:|::....::||.|:|       |...||      :|..|..|.:...|.:...::.:.
Zfish   301 TSCTGVLPQLGMVKYNCNKCNFILGPFFQSQNQEV------KPGSCPECQSLGPFEINMEQTVYQ 359

  Fly   351 DKQLVKLQESPDDMAAGQTPH--NVLLYAHNDLVDKVQPGDRVTVTGIYRATPLKTGGLS-SSVK 412
            :.|.:.:||||..:|||:.|.  :.:|.|  ||||..:|||.:.:||||...  ..|.|: ::..
Zfish   360 NYQRITIQESPGKVAAGRLPRSKDAILLA--DLVDMCKPGDEIELTGIYHNN--YDGSLNMANGF 420

  Fly   413 SVYKTHVDVVHFRKVDNKRLYEDEEGKDHIFPPERVELLQLLAKKPDIYDRLARAIAPSIYENDD 477
            .|:.|.:...|..:.|......:...:|       |:.:..|:|...|.:|:..:|.||||.::|
Zfish   421 PVFATVILANHIARKDEGVAVAELTDED-------VKAIVALSKDERIGERIFASIGPSIYAHED 478

  Fly   478 IKKGILLQLFGGTKKKHATLGRQNFRSEIHLLLCGDPGTSKSQMLQYVFNLVPRSQYTSGRGSSA 542
            ||:|:.|.||||..|...  |:...|.:|::||||||||:|||.|:||..:..|:.:|:|:|:||
Zfish   479 IKRGLALALFGGEAKNPG--GKHKVRGDINVLLCGDPGTAKSQFLKYVEKVASRAVFTTGQGASA 541

  Fly   543 VGLTAYVTKDPETRQLVLQTGALVLADNGVCCIDEFDKMNDSTRSVLHEVMEQQTLSIAKAGIIC 607
            |||||||.:.|.:|:..|:.|||||||.|||.|||||||||..|:.:||.||||::||:||||:.
Zfish   542 VGLTAYVQRHPVSREWTLEAGALVLADRGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVT 606

  Fly   608 QLNARTSILAAANPAESQWNKRKNIIDNVQLPHTLLSRFDLIFLVLDPQDEIFDKRLASHLVSLY 672
            .|.||.:::|||||...:::......:||.|...::||||::.:|.|..|.:.|:.||..:|. .
Zfish   607 SLQARCTVIAAANPIGGRYDPSLTFSENVDLTEPIISRFDVLCVVRDTVDPVQDEMLARFVVG-S 670

  Fly   673 YVTRHE----------EEDTM---FDM-----SVLRDYIAYAREHLSPTLSDEAQQRLIQAYVDM 719
            ::..|.          ||..:   ||:     .:||.||.||:|.:.|.|:...|.::.:.|.|:
Zfish   671 HIKHHPSNKEGGVAGLEEVVLPNTFDVPPIPQELLRKYIIYAKERVRPKLNQMDQDKVARIYSDL 735

  Fly   720 RKVGAGRGQISAYPRQLESLIRLSEAHAKVRLSNQVELLDVEEAWRLHREALKQSATDPLSGKID 784
            ||.....|.|....|.:||:||::||||::.|.:.|...||..|.|:..|:.           ||
Zfish   736 RKESMATGSIPITVRHIESMIRMAEAHARMHLRDYVLEDDVNMAIRVMLESF-----------ID 789

  Fly   785 V---GILTTGLST-----AARKKRADLVAAIKENLKKKGKVLTVPYQKLFSDIKEGSQIMITREQ 841
            .   .::.:...|     |.|:...:|:..|.:.|..:    .|.||:    .:.|:|    ::.
Zfish   790 TQKFSVMRSMRKTFARYLAFRRDNNELLLFILKQLVSE----QVSYQR----NRYGAQ----QDT 842

  Fly   842 FEDALKEVQDE 852
            .|.|.|::.|:
Zfish   843 IEIAEKDLVDK 853

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dpa	NP_477185.1	PHA03307	2..>150	CDD:223039	37/172 (22%)
		MCM_N	165..267	CDD:464206	24/110 (22%)
		MCM	270..772	CDD:214631	195/529 (37%)
mcm2	NP_775364.2	MCM2_N	57..170	CDD:403724	22/113 (19%)
		MCM_N	185..273	CDD:464206	23/107 (21%)
		MCM	279..788	CDD:214631	195/539 (36%)