DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpa and mcm-2

DIOPT Version :9

Sequence 1:	NP_001286160.1	Gene:	dpa / 35679	FlyBaseID:	FBgn0015929	Length:	866	Species:	Drosophila melanogaster
Sequence 2:	NP_001022416.1	Gene:	mcm-2 / 174841	WormBaseID:	WBGene00003154	Length:	881	Species:	Caenorhabditis elegans

Alignment Length:	755	Identity:	239/755 - (31%)
Similarity:	378/755 - (50%)	Gaps:	98/755 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 GNISLPATSPARGLGANMSEIDLSSPLNYGTPSSMGSIRTPRSGIRGTPLRARPDIRTDKRIRQV 121
            |::|:.|...|....|...::.....|.|....| ..:.|.|   ||...|.|.|...|..:...
Worm    78 GSLSVSARRAAEREMAQRDQLLDDDALMYEDGDS-EEVDTRR---RGRGRRGRGDAADDDSVPME 138

  Fly   122 AIGGGSGLEPIPE------KGSETTDPVSESSQAPQLVVWGTNVVVSQCKSKFKSFIMRFIDPSA 180
            .       |.||.      :|....|.||:.:            |..:.:.:||:|:..|.:|..
Worm   139 E-------EDIPVDILENIRGRTIRDHVSDEA------------VAKEIERRFKNFLRSFHEPGN 184

  Fly   181 EQDEISENIDVNQPLYLQKLEEI-----HTLEEPYLNLNCAHLKTFDQDLYRQLICY-----PQE 235
            :|.:           |:|.::.:     .:||..:.:|:        .|...|.|.|     |.|
Worm   185 KQTK-----------YIQMIKSMAADNRESLEVSFTDLS--------DDNGEQNISYFLPEAPNE 230

  Fly   236 VIPGFDMAINEMFFERYP-AALLEHQIQVRPFNADKTRNMRSLNPEDMDQLISISGMVIRSSNVI 299
            ::...|.|..|:....|| .:.:.::|:||........::|.|....::.||..:|:|..:|.::
Worm   231 MLAIMDRAATEVVMNMYPFYSRVCNEIKVRISQLPVEEDIRMLRQVHLNMLIRTAGVVTIASGIL 295

  Fly   300 PEMREAFFSCNICSF--STTVEVDRGRINQPTLCTNCNTNHCFRLIHNRSEFTDKQLVKLQESPD 362
            |::....:.|..|.:  ...|:.:...: :||:|.:|.....|.|....:.:.:.|.:.:||||:
Worm   296 PQLAVVKYDCVACGYLLGPFVQQNDEEV-RPTICPSCQGKGPFELNVENTVYHNYQRITMQESPN 359

  Fly   363 DMAAGQTPHNVLLYAHNDLVDKVQPGDRVTVTGIYRATPLKTGGLSSSV--KSVYKTHVDVVHFR 425
            .:|||:.|.:..:....||.|..:|||.:.|||:|      |.....|:  |..:.....::|..
Worm   360 KVAAGRLPRSKDVILLGDLCDSCKPGDEIEVTGVY------TNNFDGSLNYKQGFPVFNTLIHAN 418

  Fly   426 KVDNKRLYEDEEGKDHIFPPERVELLQLLAKKPDIYDRLARAIAPSIYENDDIKKGILLQLFGGT 490
            .:.||    |:...|.: ..|.::.::.|::.|:|..|:..:||||||.:||:|:.|.|.||.|.
Worm   419 HITNK----DKMASDQL-TDEDIKAIRELSQDPNISQRVFSSIAPSIYGHDDVKRAIALALFRGE 478

  Fly   491 KKKHATLGRQNFRSEIHLLLCGDPGTSKSQMLQYVFNLVPRSQYTSGRGSSAVGLTAYVTKDPET 555
            .|...  .:...|.:|::||||||||:|||.|:|..::.|||..|:|:|:|||||||||.:.|.|
Worm   479 AKNPG--AKHRLRGDINVLLCGDPGTAKSQFLRYAAHIAPRSVLTTGQGASAVGLTAYVQRHPVT 541

  Fly   556 RQLVLQTGALVLADNGVCCIDEFDKMNDSTRSVLHEVMEQQTLSIAKAGIICQLNARTSILAAAN 620
            |:..|:.||:||||.|||.|||||||:|..|:.:||.||||::||:||||:..|:||.:::||:|
Worm   542 REWTLEAGAMVLADKGVCLIDEFDKMSDQDRTSIHEAMEQQSISISKAGIVTSLHARCTVIAASN 606

  Fly   621 PAESQWNKRKNIIDNVQLPHTLLSRFDLIFLVLDPQDEIFDKRLASHLVSLYYVTRHE------- 678
            |...::|..:...:||.|...:|||||::.::.|..|.:.|:|||..:|. .:.|.|.
Worm   607 PIGGRYNPTRTFAENVDLTEPILSRFDVLCVIRDSVDSVEDERLAKFVVG-NHRTHHPDAKKIVK 670

  Fly   679 -----EEDTM--------FDMSVLRDYIAYAREHLSPTLSDEAQQRLIQAYVDMRKVGAGRGQIS 730
                 |||.|        ....:||.||.||||...|||.::..::....:..|||.....|.::
Worm   671 EGDELEEDQMDERTGVRLIPQDLLRKYIIYAREKCHPTLPEQHSEKFSNIFAQMRKESMATGSVA 735

  Fly   731 AYPRQLESLIRLSEAHAKVRLSNQVELLDVEEAWRLHREA 770
            ...|.:||:|||||||||:.|.:.|...|...|.|:..|:
Worm   736 ITVRHVESMIRLSEAHAKLHLRSYVNDEDCAAAIRVMLES 775

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpa	NP_001286160.1	PHA03307	2..>150	CDD:223039	23/98 (23%)
		MCM_N	168..267	CDD:379644	25/109 (23%)
		MCM	270..772	CDD:214631	190/525 (36%)
mcm-2	NP_001022416.1	MCM2_N	48..>103	CDD:289392	5/24 (21%)
		MCM_N	171..286	CDD:291233	29/133 (22%)
		MCM	270..777	CDD:214631	190/521 (36%)
		AAA	461..639	CDD:99707	90/179 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54431
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.930