DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpa and Mcm6

DIOPT Version :9

Sequence 1:	NP_001286160.1	Gene:	dpa / 35679	FlyBaseID:	FBgn0015929	Length:	866	Species:	Drosophila melanogaster
Sequence 2:	NP_032593.1	Gene:	Mcm6 / 17219	MGIID:	1298227	Length:	821	Species:	Mus musculus

Alignment Length:	684	Identity:	224/684 - (32%)
Similarity:	348/684 - (50%)	Gaps:	99/684 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   147 SQAPQLVVWGTNVVVSQCKSKFKSFIMRFIDPSAEQDEISENIDVNQPLYLQKLEEIHTLEEPYL 211
            ||.|::    .:.|..:|:..|..|:..|   .....||.         |||..||:...|...|
Mouse    13 SQHPEV----RDEVAEKCQKLFLDFLEEF---QGSDGEIK---------YLQFAEELIRPERNTL 61

  Fly   212 NLNCAHLKTFDQDLYRQLICYPQEVIPGFDMAINEMFFERYP--AALLEHQIQVR---PFNAD-- 269
            .::.|.|:.|:|.|               ...|.|.|:..||  ...|:..::.|   ||..|
Mouse    62 VVSFADLEQFNQQL---------------STTIQEEFYRVYPYLCRALKTFVKDRKEIPFAKDFY 111

  Fly   270 ------KTRN-MRSLNPEDMDQLISISGMVIRSSNVIPEMREAFFSCNICSFSTTVEVD---RGR 324
                  .||: :|.|....:..|..|||.|:|:..|.||:....|.|..|.   ||..|   :.:
Mouse   112 VAFQDLPTRHKIRELTSSRIGLLTRISGQVVRTHPVHPELVSGTFLCLDCQ---TVIKDVEQQFK 173

  Fly   325 INQPTLCTN--CNTNHCFRLIHNRSEFTDKQLVKLQESPDDMAAGQTPHNVLLYAHNDLVDKVQP 387
            ..||.:|.|  |.....|.|..|:|.|.|.|.|::||:..::..|..|.::.:....:.|:..|.
Mouse   174 YTQPNICRNPVCANRKRFLLDTNKSRFVDFQKVRIQETQAELPRGSIPRSLEVILRAEAVESAQA 238

  Fly   388 GDRVTVTGIYRATP----LKTGGLSSSVKS------VYKTH---------VDVVHFRKV------ 427
            |||...||.....|    |.|.|..:...|      .|:|.         |..:.:|.|
Mouse   239 GDRCDFTGALIVVPDVSKLSTPGARAETNSRVSGADGYETEGIRGLRALGVRDLSYRLVFLACHV 303

  Fly   428 -------DNKRLYEDEEGKDHI---FPPERVELLQLLAKKPDIYDRLARAIAPSIYENDDIKKGI 482
                   ..|.|.::|:..:.|   ...:..|.:..:::..::|..|..::.|:|:.||::|:|:
Mouse   304 APTNPRFGGKELRDEEQTAESIKNQMTVKEWEKVFEMSQDKNLYHNLCTSLFPTIHGNDEVKRGV 368

  Fly   483 LLQLFGGTKKKHATLGR-QNFRSEIHLLLCGDPGTSKSQMLQYVFNLVPRSQYTSGRGSSAVGLT 546
            ||.||||..|   |.|. .:.|.:|::.:.|||.|:|||.|::|....||:.||||:.|||.|||
Mouse   369 LLMLFGGVPK---TTGEGTSLRGDINVCIVGDPSTAKSQFLKHVDEFSPRAVYTSGKASSAAGLT 430

  Fly   547 AYVTKDPETRQLVLQTGALVLADNGVCCIDEFDKMNDSTRSVLHEVMEQQTLSIAKAGIICQLNA 611
            |.|.:|.|:.:.|::.|||:|||||||||||||||:...:..:||.|||||:||.|||:...|||
Mouse   431 AAVVRDEESHEFVIEAGALMLADNGVCCIDEFDKMDMRDQVAIHEAMEQQTISITKAGVKATLNA 495

  Fly   612 RTSILAAANPAESQWNKRKNIIDNVQLPHTLLSRFDLIFLVLDPQDEIFDKRLASHLVSLYYVTR 676
            ||||||||||....:::.|::..|:.|...::|||||.|:::|..:|:.|..:|..:|.|:  :|
Mouse   496 RTSILAAANPVSGHYDRSKSLKQNINLSAPIMSRFDLFFILVDECNEVTDYAIARRIVDLH--SR 558

  Fly   677 HEEE-DTMFDMSVLRDYIAYAREHLSPTLSDEAQQRLIQAYVDMRK---VGAGRGQISAYPRQLE 737
            .||. |.::.:..:|.|:.:||: ..|.:|.|::..:::.|..:|:   .|..:.......||||
Mouse   559 IEESIDRVYSLDDIRRYLLFARQ-FKPKISKESEDFIVEQYKRLRQRDGSGVTKSSWRITVRQLE 622

  Fly   738 SLIRLSEAHAKVRLSNQVELLDVEEAWRLHREAL 771
            |:|||||:.|::...::|:...|:||:||..:::
Mouse   623 SMIRLSESMARMHCCDEVQPKHVKEAFRLLNKSI 656

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpa	NP_001286160.1	PHA03307	2..>150	CDD:223039	2/2 (100%)
		MCM_N	168..267	CDD:379644	25/103 (24%)
		MCM	270..772	CDD:214631	192/548 (35%)
Mcm6	NP_032593.1	MCM_N	29..139	CDD:291233	33/136 (24%)
		MCM	119..657	CDD:214631	192/547 (35%)
		P-loop_NTPase	<447..534	CDD:304359	51/86 (59%)
		Arginine finger	528..531		2/2 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	676..708
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820