DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpa and Mcm5

DIOPT Version :9

Sequence 1:	NP_001286160.1	Gene:	dpa / 35679	FlyBaseID:	FBgn0015929	Length:	866	Species:	Drosophila melanogaster
Sequence 2:	NP_001289469.1	Gene:	Mcm5 / 17218	MGIID:	103197	Length:	734	Species:	Mus musculus

Alignment Length:	752	Identity:	243/752 - (32%)
Similarity:	388/752 - (51%)	Gaps:	101/752 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   141 DPVSESSQAPQLVVWGTNVVVSQCKSKFKSFIMRFIDPSAEQDEISENIDVNQP----LYLQKLE 201
            ||.:|..||.:          ||.:.:||.|:.::            .:..::.    .|..:|:
Mouse    18 DPGAEEGQARK----------SQLQRRFKEFLRQY------------RVGTDRTGFTFKYRDELK 60

  Fly   202 EIHTLEEPYLNLNCAHLKTFDQDLYRQLICYPQEVIPGFDMAINEMFFE----RYPAALLEHQIQ 262
            ..:.|.|.::.:....|.:||::|...|...|.|.:...:.|..|:..|    |.....|...||
Mouse    61 RHYNLGEYWIEVEMEDLASFDEELADHLHKQPAEHLQLLEEAAKEVADEVTRPRPAGDELLQDIQ 125

  Fly   263 VRPFNADKTRNMRSLNPEDMDQLISISGMVIRSSNVIPEMREAFFSCNICSFSTTVEVDRGRINQ 327
            |...:.....::|.|..:.|..|:.|.|::|.:|.|..:.......|..|..:.|....|..:..
Mouse   126 VMLKSDASPSSIRILKSDMMSHLVKIPGIIISASAVRAKATRISIQCRSCHNTLTNIAMRPGLEG 190

  Fly   328 PTLCTNCNTNHCFR---------LIHNRSEFTDKQLVKLQESPDDMAAGQTPHNVLLYAHNDLVD 383
            ..|...||.:...|         ::.::.:..|.|.:||||.||.:..|:.|.::.||....|.|
Mouse   191 YALPRKCNMDQAGRPKCPLDPYFIMPDKCKCVDFQTLKLQELPDAVPHGEMPRHMQLYCDRYLCD 255

  Fly   384 KVQPGDRVTVTGIYRATPLKTGGLSSS---------VKSVYKTHVDVVHFRKVDNKRLYEDEEGK 439
            ||.||:|||:.|||   .:|..||:.|         ::|.|   :.|:        .:..|.:|.
Mouse   256 KVVPGNRVTIMGIY---SIKKFGLNPSKGRDRVGVGIRSSY---IRVL--------GIQVDTDGS 306

  Fly   440 DHIF----PPERVELLQLLAKKPDIYDRLARAIAPSIYENDDIKKGILLQLFGGTKKKHAT-LGR 499
            ...|    .|:..|..:.||..|:||:.::::|:|||:...|:||.|...||||::|:... |.|
Mouse   307 GRSFAGSVSPQEEEEFRRLAALPNIYELISKSISPSIFGGMDMKKAIACLLFGGSRKRLPDGLTR 371

  Fly   500 QNFRSEIHLLLCGDPGTSKSQMLQYVFNLVPRSQYTSGRGSSAVGLTAYVTKDPETRQLVLQTGA 564
               |.:|:||:.|||||:|||:|::|....|...||||:||||.||||.|.:||.:|..:::.||
Mouse   372 ---RGDINLLMLGDPGTAKSQLLKFVEKCSPIGVYTSGKGSSAAGLTASVIRDPSSRNFIMEGGA 433

  Fly   565 LVLADNGVCCIDEFDKMNDSTRSVLHEVMEQQTLSIAKAGIICQLNARTSILAAANPAESQWNKR 629
            :||||.||.||||||||.:..|..:||.|||||:|||||||...||:|.|:|||||....:|::.
Mouse   434 MVLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGITTTLNSRCSVLAAANSVFGRWDET 498

  Fly   630 KNIIDNVQLPHTLLSRFDLIFLVLDPQDEIFDKRLASHLVSLYY--VTRHEEEDTMFDMSVLRDY 692
            |. .||:....|:|||||:||:|.|..:|..|..||.|:::|:.  :|:.:..:...|::.::.:
Mouse   499 KG-EDNIDFMPTILSRFDMIFIVKDEHNEERDMMLAKHVMTLHVSALTQTQAVEGEIDLAKMKKF 562

  Fly   693 IAYAREHLSPTLSDEAQQRLIQAYVDMRKVGA--------GRGQISAYPRQLESLIRLSEAHAKV 749
            |||.|....|.||.||.::|...|:.||. ||        .|..|....||||:::|::||.:|:
Mouse   563 IAYCRARCGPRLSAEAAEKLKNRYIIMRS-GARQHERDSDRRSSIPITVRQLEAIVRIAEALSKM 626

  Fly   750 RLSNQVELLDVEEAWRLHREALKQSATDPLSGKIDVGILTTGLSTAARKKRADLVAAIKENLKKK 814
            :|.......|||||.||.:.:...:|   |||.:      :|:.....::..::::.|::.||::
Mouse   627 KLQPFATEADVEEALRLFQVSTLDAA---LSGNL------SGVEGFTTQEDQEMLSRIEKQLKRR 682

  Fly   815 GKVLTVPYQKLFSDIKEGSQIM-ITREQF-EDALKEV 849
            ..:        .|.:.|.|.:. .|:::: |.|:::|
Mouse   683 FAI--------GSQVSEHSIVQDFTKQKYPEHAIRKV 711

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpa	NP_001286160.1	PHA03307	2..>150	CDD:223039	4/8 (50%)
		MCM_N	168..267	CDD:379644	22/106 (21%)
		MCM	270..772	CDD:214631	199/534 (37%)
Mcm5	NP_001289469.1	MCM_N	35..130	CDD:379644	22/106 (21%)
		MCM	133..649	CDD:214631	199/534 (37%)
		Arginine finger	512..515		2/2 (100%)
		BREX_BrxC	<618..>730	CDD:380283	27/111 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820