Protein Alignment dpa and Mcm4

DIOPT Version :10

• Sequence 1: NP_477185.1
• Gene: dpa / 35679
• FlyBaseID: FBgn0015929
• Length: 866
• Species: Drosophila melanogaster
• Sequence 2: NP_032591.3
• Gene: Mcm4 / 17217
• MGIID: 103199
• Length: 862
• Species: Mus musculus
• Alignment Length: 879
• Identity: 534/879 - (60%)
• Similarity: 680/879 - (77%)
• Gaps: 32/879 - (3%)

  Fly     1 MSSPARSPSVGGATPKQGARTPTRGIASQDVETPMRMGPGRAVRPSDNIS---LP-PTSPG-NIS 60
            |||||.:||  ..:.::|..|||:.:.|::    .|..|.|..|..|:.:   || ||||| ::.
Mouse     1 MSSPASTPS--RRSSRRGRVTPTQSLRSEE----SRSSPNRRRRGEDSSTGELLPMPTSPGADLQ 59

  Fly    61 LP-------ATSPARGLGANMSEIDLSSPLNYGTPSSMGSIRTPRSGIRGTPLRARPDIRTDKRI 118
            .|       ::.|.....|...:.|:||||.||||||... .|||||:||||:|.|||:.:.::.
Mouse    60 SPPAQNALFSSPPQMHSLAIPLDFDVSSPLTYGTPSSRVE-GTPRSGVRGTPVRQRPDLGSARKG 123

  Fly   119 RQVAIGGGSGLEPIPEKGSETTDPV-SESSQAPQLVVWGTNVVVSQCKSKFKSFIMRFIDPSAEQ 182
            .||         .:...|:...|.| ||.|...:||:|||:|.|:.||..|:.|:..|.||.|::
Mouse   124 LQV---------DLQSDGAAAEDIVPSEQSLGQKLVIWGTDVNVATCKENFQRFLQCFTDPLAKE 179

  Fly   183 DEISENIDVNQPLYLQKLEEIHTLEEPYLNLNCAHLKTFDQDLYRQLICYPQEVIPGFDMAINEM 247
            :| :..||:.||||:|:|.||:...||:||:||.|:|:|.::||||||.|||||||.||||:||:
Mouse   180 EE-NVGIDITQPLYMQQLGEINITGEPFLNVNCEHIKSFSKNLYRQLISYPQEVIPTFDMAVNEI 243

  Fly   248 FFERYPAALLEHQIQVRPFNADKTRNMRSLNPEDMDQLISISGMVIRSSNVIPEMREAFFSCNIC 312
            ||:|||.::||||||||||||.||::||:|||||:||||:|||||||:|.:||||:||||.|.:|
Mouse   244 FFDRYPDSILEHQIQVRPFNALKTKSMRNLNPEDIDQLITISGMVIRTSQLIPEMQEAFFQCQVC 308

  Fly   313 SFSTTVEVDRGRINQPTLCTNCNTNHCFRLIHNRSEFTDKQLVKLQESPDDMAAGQTPHNVLLYA 377
            :.:|.||:|||||.:|..|.:|:|.|...||||||.|:|||::||||||:||.||||||.::|:|
Mouse   309 AHTTRVEIDRGRIAEPCSCVHCHTTHSMALIHNRSFFSDKQMIKLQESPEDMPAGQTPHTIVLFA 373

  Fly   378 HNDLVDKVQPGDRVTVTGIYRATPLKTGGLSSSVKSVYKTHVDVVHFRKVDNKRLYE-DEEGKDH 441
            ||||||||||||||.|||||||.|::.....|:||||||||:||:|:||.|.|||:. |||.:..
Mouse   374 HNDLVDKVQPGDRVNVTGIYRAVPIRVNPRVSNVKSVYKTHIDVIHYRKTDAKRLHGLDEEAEQK 438

  Fly   442 IFPPERVELLQLLAKKPDIYDRLARAIAPSIYENDDIKKGILLQLFGGTKKKHATLGRQNFRSEI 506
            :|..:||:||:.|::|||||:|||.|:||||||::||||||||||||||:|..:..||..||:||
Mouse   439 LFSEKRVKLLKELSRKPDIYERLASALAPSIYEHEDIKKGILLQLFGGTRKDFSHTGRGKFRAEI 503

  Fly   507 HLLLCGDPGTSKSQMLQYVFNLVPRSQYTSGRGSSAVGLTAYVTKDPETRQLVLQTGALVLADNG 571
            ::||||||||||||:||||:|||||.|||||:|||||||||||.|||||||||||||||||:|||
Mouse   504 NILLCGDPGTSKSQLLQYVYNLVPRGQYTSGKGSSAVGLTAYVMKDPETRQLVLQTGALVLSDNG 568

  Fly   572 VCCIDEFDKMNDSTRSVLHEVMEQQTLSIAKAGIICQLNARTSILAAANPAESQWNKRKNIIDNV 636
            :||||||||||:|||||||||||||||||||||||||||||||:||||||.|||||.:|..|:|:
Mouse   569 ICCIDEFDKMNESTRSVLHEVMEQQTLSIAKAGIICQLNARTSVLAAANPIESQWNPKKTTIENI 633

  Fly   637 QLPHTLLSRFDLIFLVLDPQDEIFDKRLASHLVSLYYVTRHEEEDTMFDMSVLRDYIAYAREHLS 701
            |||||||||||||||:||||||.:|:|||.|||||||.:..:.|:...||:||:||||||...:.
Mouse   634 QLPHTLLSRFDLIFLMLDPQDEAYDRRLAHHLVSLYYQSEEQVEEEFLDMAVLKDYIAYAHSTIM 698

  Fly   702 PTLSDEAQQRLIQAYVDMRKVGAGRGQISAYPRQLESLIRLSEAHAKVRLSNQVELLDVEEAWRL 766
            |.||:||.|.||:|||:|||:|:.||.:|||||||||||||:|||||||.||:||.:|||||.||
Mouse   699 PRLSEEASQALIEAYVNMRKIGSSRGMVSAYPRQLESLIRLAEAHAKVRFSNKVEAIDVEEAKRL 763

  Fly   767 HREALKQSATDPLSGKIDVGILTTGLSTAARKKRADLVAAIKENLKKKGKVLTVPYQKLFSDIKE 831
            ||||||||||||.:|.:|:.|||||:|..:||::.:|..|:::.:..|||...:.||:||.||:.
Mouse   764 HREALKQSATDPRTGIVDISILTTGMSATSRKRKEELAEALRKLILSKGKTPALKYQQLFEDIRG 828

  Fly   832 GSQIMITREQFEDALKEVQDEGAIVVMGKNTIRI 865
            .|...||::.||:||:.:.|:..:.|.|| |:|:
Mouse   829 QSDTAITKDMFEEALRALADDDFLTVTGK-TVRL 861

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dpa	NP_477185.1	PHA03307	2..>150	CDD:223039	58/160 (36%)
		MCM_N	165..267	CDD:464206	60/101 (59%)
		MCM	270..772	CDD:214631	362/502 (72%)
Mcm4	NP_032591.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..71		25/75 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	90..121		19/31 (61%)
		MCM_N	162..263	CDD:464206	60/101 (59%)
		MCM	266..769	CDD:214631	362/502 (72%)
		Arginine finger	641..644		2/2 (100%)