Protein Alignment dpa and Mcm2

DIOPT Version :10

• Sequence 1: NP_477185.1
• Gene: dpa / 35679
• FlyBaseID: FBgn0015929
• Length: 866
• Species: Drosophila melanogaster
• Sequence 2: NP_032590.2
• Gene: Mcm2 / 17216
• MGIID: 105380
• Length: 904
• Species: Mus musculus
• Alignment Length: 958
• Identity: 268/958 - (27%)
• Similarity: 436/958 - (45%)
• Gaps: 205/958 - (21%)

  Fly     7 SPSVGGATPKQGARTPTRGIASQDVETPMRMGPGRAVRPSDNISLPPTSPGNISLPATSPARGLG 71
            |.|:..::|.:..|.         :..|:...|||:.|.:|.::   :|||....|....:.||
Mouse     5 SESLSASSPARQRRR---------ISDPLTSSPGRSSRRADALT---SSPGRDLPPFEDESEGL- 56

  Fly    72 ANMSEIDLSSPLNYGTPSSMGSIRTPRSGIRGTPLRARPDIRTDKRIRQVAIGGGSGLE----PI 132
                                       .|..| |:....|  .::.|       |.|:|    ||
Mouse    57 ---------------------------LGTEG-PMEEEED--GEELI-------GDGMERDYRPI 84

  Fly   133 PE------KGSETTDPVSESSQAPQL------------------------VVWGTNVVVSQCKSK 167
            ||      :|....|...|...|.|.                        :::.::....:..::
Mouse    85 PELDVYEAEGLALDDEDVEELTASQREAAERTMRQRDREAGRGLGRMRRGLLYDSSEEDEERPAR 149

  Fly   168 FKSFIMRFIDPSAEQDEISENIDVNQPLYLQKLEEIHTLEEPYL-------NLNCAHLKTFDQDL 225
            .:..:.|..:...|.:|:.|:|:..:.|....:.|..::..|.|       |....|:.:...::
Mouse   150 KRRHVERATEDGEEDEEMIESIENLEDLKGHSVREWVSMAGPRLEIHHRFKNFLRTHVDSHGHNV 214

  Fly   226 YRQ-------------------------LICY-----PQEVIPGFDMAINEMFFERYPA-ALLEH 259
            :::                         ::.|     |.|::..||.|..|:....||. ..:.:
Mouse   215 FKERISDMCKENRESLVVNYEDLAAREHVLAYFLPEAPAELLQIFDEAALEVVLAMYPKYDRITN 279

  Fly   260 QIQVRPFNADKTRNMRSLNPEDMDQLISISGMVIRSSNVIPEMREAFFSCNICSF-------STT 317
            .|.||..:......:|||....::|||..||:|...:.|:|::....::|:.|:|       |..
Mouse   280 HIHVRISHLPLVEELRSLRQLHLNQLIRTSGVVTSCTGVLPQLSMVKYNCSKCNFVLGPFCQSQN 344

  Fly   318 VEVDRGRINQPTLCTNCNTNHCFRLIHNRSEFTDKQLVKLQESPDDMAAGQTPH--NVLLYAHND 380
            .||      :|..|..|.:...|.:....:.:.:.|.:::||||..:|||:.|.  :.:|.|  |
Mouse   345 QEV------KPGSCPECQSAGPFEINMEETIYQNYQRIRIQESPGKVAAGRLPRSKDAILLA--D 401

  Fly   381 LVDKVQPGDRVTVTGIYRATPLKTGGLSSSVK-SVYKTHVDVVHFRKVDNKRLYEDEEGKDHIFP 444
            |||..:|||.:.:||||...  ..|.|:::.. .|:.|.:...|..|.|||....:...:|
Mouse   402 LVDSCKPGDEIELTGIYHNN--YDGSLNTANGFPVFATIILANHVAKKDNKVAVGELTDED---- 460

  Fly   445 PERVELLQLLAKKPDIYDRLARAIAPSIYENDDIKKGILLQLFGGTKKKHATLGRQNFRSEIHLL 509
               |:::..|:|...|.:::..:||||||.::|||:|:.|.||||..|...  |:...|.:|::|
Mouse   461 ---VKMITGLSKDQQIGEKIFASIAPSIYGHEDIKRGLALALFGGEPKNPG--GKHKVRGDINVL 520

  Fly   510 LCGDPGTSKSQMLQYVFNLVPRSQYTSGRGSSAVGLTAYVTKDPETRQLVLQTGALVLADNGVCC 574
            |||||||:|||.|:|:..:..|:.:|:|:|:|||||||||.:.|.:|:..|:.|||||||.|||.
Mouse   521 LCGDPGTAKSQFLKYIEKVSSRAIFTTGQGASAVGLTAYVQRHPVSREWTLEAGALVLADRGVCL 585

  Fly   575 IDEFDKMNDSTRSVLHEVMEQQTLSIAKAGIICQLNARTSILAAANPAESQWNKRKNIIDNVQLP 639
            |||||||||..|:.:||.||||::||:||||:..|.||.:::|||||...:::......:||.|.
Mouse   586 IDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTSLQARCTVIAAANPIGGRYDPSLTFSENVDLT 650

  Fly   640 HTLLSRFDLIFLVLDPQDEIFDKRLASHLVSLYYVTRHEE--------------EDTM------- 683
            ..::||||::.:|.|..|.:.|:.||..:|..:  .||..              |..|
Mouse   651 EPIISRFDVLCVVRDTVDPVQDEMLARFVVGSH--VRHHPSNKKDEGLTNGGTLEPAMPNTYGVE 713

  Fly   684 -FDMSVLRDYIAYAREHLSPTLSDEAQQRLIQAYVDMRKVGAGRGQISAYPRQLESLIRLSEAHA 747
             ....||:.||.||:|.:.|.|:...|.::.:.|.|:||.....|.|....|.:||:||::||||
Mouse   714 PLPQEVLKKYIIYAKERVRPKLNQMDQDKVARMYSDLRKESMATGSIPITVRHIESMIRMAEAHA 778

  Fly   748 KVRLSNQVELLDVEEAWRLHREALKQSATDPLSGKIDV---GILTTGLSTAA-----RKKRADLV 804
            ::.|.:.|...||..|.|:..|:.           ||.   .::.:...|.|     |:...||:
Mouse   779 RMHLRDYVMEDDVNMAIRVMMESF-----------IDTQKFSVMRSMRKTFARYLSFRRDNNDLL 832

  Fly   805 AAIKENLKKKGKVLTVPYQKLFSDIKEGSQ---IMITREQFEDALKEV 849
            ..|.:.|..:    .|.||:    .:.|:|   |.|..:...|..:::
Mouse   833 LFILKQLVAE----QVTYQR----NRFGAQQDTIEIPEKDLMDKARQI 872

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dpa	NP_477185.1	PHA03307	2..>150	CDD:223039	31/152 (20%)
		MCM_N	165..267	CDD:464206	23/139 (17%)
		MCM	270..772	CDD:214631	195/533 (37%)
Mcm2	NP_032590.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..166		35/210 (17%)
		Interaction with KAT7. /evidence=ECO:0000269|PubMed:11278932	2..257		47/301 (16%)
		Interaction with DNJC9. /evidence=ECO:0000250|UniProtKB:P49736	61..130		16/78 (21%)
		MCM2_N	72..182	CDD:403724	19/116 (16%)
		MCM_N	197..287	CDD:464206	14/89 (16%)
		MCM	291..803	CDD:214631	195/543 (36%)
		Arginine finger	655..658		2/2 (100%)