DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpa and Mcm3

DIOPT Version :9

Sequence 1:	NP_001286160.1	Gene:	dpa / 35679	FlyBaseID:	FBgn0015929	Length:	866	Species:	Drosophila melanogaster
Sequence 2:	NP_032589.1	Gene:	Mcm3 / 17215	MGIID:	101845	Length:	812	Species:	Mus musculus

Alignment Length:	678	Identity:	211/678 - (31%)
Similarity:	341/678 - (50%)	Gaps:	107/678 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   158 NVVVSQCKSKFKSFIMRFIDPSAEQDEISENIDVNQPLYLQKLEEIHTLEEPYLN--LNCAHLKT 220
            :|.:.:.:..:..|:....|....|:::.|.|..||...:..:.::....|...|  ||.|
Mouse     9 DVELREAQRDYLDFLDDEEDQGIYQNKVRELISDNQYRLIVSVNDLRRKNEKRANRLLNNA---- 69

  Fly   221 FDQDLYRQLICYPQEVIPGFDMAINEMFFERYPAALLEHQIQVRPFNADKTRNMRSLNPEDMDQL 285
                 :.:|:.: |..:..|..:|:..:.::|.    |..|.:......|..:.|:|....:..:
Mouse    70 -----FEELVAF-QRALKDFVASIDATYAKQYE----EFYIGLEGSFGSKHVSPRTLTSCFLSCV 124

  Fly   286 ISISGMVIRSSNVIPEMREAFFSCNICSFSTTVEVDRGRINQPTLC---------TNCNTNHCFR 341
            :.:.|:|.:.|.|.|::..:...|.    :|...::|...:..||.         |....|:...
Mouse   125 VCVEGIVTKCSLVRPKVVRSVHYCP----ATKKTIERRYSDLTTLVAFPSSSVYPTKDEENNPLE 185

  Fly   342 LIHNRSEFTDKQLVKLQESPDDMAAGQTPHNVLLYAHNDLVDKVQPGDRVTVTGIYRATPLKTGG 406
            ..:..|.:.|.|.:.:||.|:...|||.|.:|.:...:||||||:||||:.|.|.||..|.|.|.
Mouse   186 TEYGLSVYKDHQTITIQEMPEKAPAGQLPRSVDVILDDDLVDKVKPGDRIQVVGTYRCLPGKKGC 250

  Fly   407 LSSSVKSVYKTHVDVVHFRKV----DNKRLYEDEEGKDHIFPPERVELLQLLAK--KPDIYDRLA 465
            .:|..            ||.|    :.|::.:|.:   ..|..:.:..::..:|  ..|::::||
Mouse   251 YTSGT------------FRTVLIACNVKQMSKDIQ---PAFSADDIAKIKKFSKTRSKDVFEQLA 300

  Fly   466 RAIAPSIYENDDIKKGILLQLFGGTKKKHATLGRQNFRSEIHLLLCGDPGTSKSQMLQYVFNLVP 530
            |::||||:.:|.:||.||..|.||.:::  .....:.|.:|::||.|||..:|||:|:||....|
Mouse   301 RSLAPSIHGHDYVKKAILCLLLGGVERE--LENGSHIRGDINILLIGDPSVAKSQLLRYVLCTAP 363

  Fly   531 RSQYTSGRGSSAVGLTAYVTKDPETRQLVLQTGALVLADNGVCCIDEFDKMNDSTRSVLHEVMEQ 595
            |:..|:|||||.|||||.||.|.||.:..|:.||:||||.||.||||||||:|..|:.:||||||
Mouse   364 RAIPTTGRGSSGVGLTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDMDRTAIHEVMEQ 428

  Fly   596 QTLSIAKAGIICQLNARTSILAAANPAESQWNKRKNIIDNVQLPHTLLSRFDLIFLVLDPQDEIF 660
            ..::||||||..:||||.|:||||||...::::.|..::|:.|..:|||||||:|::||..|...
Mouse   429 GRVTIAKAGIHARLNARCSVLAAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQ 493

  Fly   661 DKRLASHLVSLYY---------------------------VTRHEEEDT---------------- 682
            |:.::.|::.::.                           .|:.:::||
Mouse   494 DREISDHVLRMHQYRAPGEQDGDALPLGSSVDILATDDPDFTQDDQQDTRIYEKHDSLLHGTKKK 558

  Fly   683 ---MFDMSVLRDYIAYAREHLSPTLSDEAQQRLIQAYVDMRKVG------AGRGQISAYPRQLES 738
               |...:.::.||..|: .:.|||:.|:...:.:.|..:|...      |....::|  |.||:
Mouse   559 KEKMVSAAFMKKYIHVAK-IIKPTLTQESAAYIAEEYSRLRSQDSMSSDTARTSPVTA--RTLET 620

  Fly   739 LIRLSEAHAKVRLSNQVELLDVEEAWRL 766
            ||||:.||||.|:|..|:|.|.|||..|
Mouse   621 LIRLATAHAKARMSKTVDLQDAEEAVEL 648

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpa	NP_001286160.1	PHA03307	2..>150	CDD:223039
		MCM_N	168..267	CDD:379644	19/100 (19%)
		MCM	270..772	CDD:214631	191/564 (34%)
Mcm3	NP_032589.1	MCM_N	17..129	CDD:291233	22/125 (18%)
		MCM	109..654	CDD:214631	191/564 (34%)
		P-loop_NTPase	340..479	CDD:304359	77/138 (56%)
		Arginine finger	477..480		2/2 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	664..744
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810