DRSC/TRiP Functional Genomics Resources

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Protein Alignment dpa and MCMDC2

DIOPT Version :10

Sequence 1:NP_477185.1 Gene:dpa / 35679 FlyBaseID:FBgn0015929 Length:866 Species:Drosophila melanogaster
Sequence 2:NP_775789.3 Gene:MCMDC2 / 157777 HGNCID:26368 Length:681 Species:Homo sapiens


Alignment Length:732 Identity:134/732 - (18%)
Similarity:241/732 - (32%) Gaps:232/732 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   156 GTNVVVSQCK----SKFKSFIMRF---IDPS--AEQDEISENIDVNQPL---------------Y 196
            |....:..||    ||....:.||   |:||  .|.|....|..::|||               .
Human    19 GLQKFIDDCKYYNDSKQSYAVYRFKILINPSDVVELDAELGNHILHQPLKAAEVFQSVCFIAVKT 83

  Fly   197 LQKLEEIHTLEEPYLNLNCAHLKTFDQDLYRQLICYPQEVIPGFDMAINEMFFERYPAALLEHQI 261
            |..:.::.|..:..:.|...||..                :|.:.:.:.|               
Human    84 LSLIGQLQTETQINIVLKLTHLPP----------------LPSYGLDLCE--------------- 117

  Fly   262 QVRPFNADKTRNMRSLNPEDMDQLISISGMVIRSSNVIPEMREAFFSCN--ICSFSTTVEVDR-- 322
                |..|.|          ..:...:.|:||..:.:....:.|.|.|:  .|..|...:..|  
Human   118 ----FPLDYT----------SQRFYMMQGIVIAMTTITKYTQGARFLCSDEACPLSKGFQYIRVH 168

  Fly   323 --GRINQPTLCTNCNTNHCFRLIHNRSEFT---DKQLVKLQESPDDMA----AGQTP---HNVLL 375
              |.....|:..:...|.|...:....:|.   |||:|::..:....|    :...|   .::.:
Human   169 VPGATESATIRNDFLCNLCASSLQEDRKFRVLGDKQIVEIIATKALRAFQGYSNNQPFRFQSLTI 233

  Fly   376 YAHNDLVDKVQPGDRVTVTGIYRATPLKTGGLSSSVKSVYKTHVDVVHFRKV-----DNKRLYED 435
            :..::.|:|:..|:...:.||  .|.:||...:..:::...|..:    .||     ||.|.   
Human   234 FLRDESVNKMNIGNEYKIIGI--PTCVKTSQTAVCIEANSITFCN----SKVPSGISDNFRC--- 289

  Fly   436 EEGKDHIFPPERVELLQLLAKK------------------PDIYDRLARAIAPSIYENDDIKKGI 482
                          ||.|.:..                  |..|:.|...:..|:.:..|..|  
Human   290 --------------LLSLTSSSCWKFTAILANIFASQITPPGTYNLLKLCLLMSLVQTTDRNK-- 338

  Fly   483 LLQLFGGTKKKHATLGRQNFRSEIHLLLCGDPGTSKSQMLQYVFNLVPRSQYTSGRGSSAVGLTA 547
                              .....:.:|:.........::|.:..|||||            |:..
Human   339 ------------------ELEDCLDILIITSDTLLIDRLLNFSINLVPR------------GIRH 373

  Fly   548 YVTKD--PE-------TRQLVLQTGALVLADNGVCCIDEFDKMNDSTRSVLHEVMEQQTLSIAKA 603
            .|:.:  |.       |..:.:|.|:.:||..|:|.|.:...........|..|:|.:::::...
Human   374 LVSTEIFPTLSRNKYGTGAVSIQAGSALLAKGGICFIGDLASHKKDKLEQLQTVLESRSITVYIP 438

  Fly   604 G--------------IICQLNARTSILAAANPAESQWNKRKNIIDNVQLPHTLLSRFDLI----- 649
            |              :.|...:...:.:::.....:.|.....:|...:|..|:..|.|:     
Human   439 GKKFGEDIDQQMTFPVQCSFWSFVDVDSSSRRNAQKINTLIGQMDCSLIPANLVEAFGLLINCNE 503

  Fly   650 ------FL---------VLDPQDEIFDKRLASHLVSLYYVTRHEEEDTMFDMSVLRDYIAYAREH 699
                  ||         .::|:             .|:|....:     |........:|:|: :
Human   504 SSPCHPFLPTVQHTLNKAINPE-------------GLFYAASRQ-----FTTEDFEKLLAFAK-N 549

  Fly   700 LSPTLSDEAQQRLIQAYVDMRKVGAGR---GQISAYPRQLESLIRLSEAHAKVRLSNQVELLDVE 761
            |:...|.||::.....|:..|::..|.   .::||  ..|:.|:.||||||::.|.|:|...||.
Human   550 LNVEFSLEAERMTHGYYLASRRIRTGSVCGSKLSA--SALKYLVFLSEAHARLNLRNKVLKEDVL 612

  Fly   762 EAWRLHREA--LKQSAT 776
            .|..|...:  ||..||
Human   613 IAALLFETSLTLKYGAT 629

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dpaNP_477185.1 PHA03307 2..>150 CDD:223039
MCM_N 165..267 CDD:464206 21/125 (17%)
MCM 270..772 CDD:214631 105/588 (18%)
MCMDC2NP_775789.3 MCM <390..621 CDD:475121 51/251 (20%)
Blue background indicates that the domain is not in the aligned region.

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