DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpa and mcm8

DIOPT Version :9

Sequence 1:	NP_001286160.1	Gene:	dpa / 35679	FlyBaseID:	FBgn0015929	Length:	866	Species:	Drosophila melanogaster
Sequence 2:	XP_002665161.2	Gene:	mcm8 / 100333576	ZFINID:	ZDB-GENE-120927-1	Length:	852	Species:	Danio rerio

Alignment Length:	836	Identity:	247/836 - (29%)
Similarity:	392/836 - (46%)	Gaps:	128/836 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   117 RIRQVAIGGGSGLEPIPEKGSETTDPVSESSQAPQLVVWGTNVVVSQCK---------SKFKSFI 172
            |.||.:.|||.|      :|:.:.:. ::...|||         |||.:         ..:|.:.
Zfish    43 RGRQWSGGGGGG------RGNYSNNN-TQKGNAPQ---------VSQARVTQATLDITCPYKGWR 91

  Fly   173 MRFIDPSAEQDEISENIDVNQPLYLQKL-----EEIH-------TLEEPYLNLNCAHLKTFDQDL 225
            :.|.:...|.....|.|.|.:..:..::     :||.       ..::...|...:|..   .||
Zfish    92 LYFSEGFVESSPYVEKIKVFEQYFTSQIDLYDKDEIERKGSILVDYKDLLSNKQVSHSL---PDL 153

  Fly   226 YRQLICYPQEVIPGFDMAINEMF---FERYPAAL---------------LEHQIQVRPFNADKTR 272
            .|.|...|::::....:||:::.   .||:.|.|               :.| |..|.:|.:...
Zfish   154 ARDLKEMPEKILDCLGVAIHQVLTLDLERHAAELQGQEELPAGIRPIINIPH-ISARLYNYEPLT 217

  Fly   273 NMRSLNPEDMDQLISISGMVIRSSNVIPEMREAFFSCNICSFSTTVEVDRGRINQPTLC--TNCN 335
            .::||......:.:.|.|.|:|.||:.|...:..|.||.|..:.:|.:..|:...||.|  :.|.
Zfish   218 PLKSLRANLYGKFVVIRGTVVRVSNIKPLCMKLAFVCNSCGDTQSVTLPDGKYTMPTKCLQSECR 282

  Fly   336 TNHCFRLIHNRSE-FT---DKQLVKLQE--SPDDMAAGQTPHNVLLYAHNDLVDKVQPGDRVTVT 394
            ..   ....|||. ||   |.|.:|:||  |.|...:|:.|..:......||||...|||.||:|
Zfish   283 GR---SFTPNRSSPFTLTVDWQTIKVQELMSGDQRESGRIPRTIECELTQDLVDSCVPGDMVTIT 344

  Fly   395 GIYRATPLKTGGLSSSVKSVYKTHV---DVVHFRKVDNKRLYEDE-EGKDHIFPPERVELLQLLA 455
            |:.:.:..:....:...|.::..::   .|.:.:...:|.:.|.| :|....|..:.:..:|.:.
Zfish   345 GVIKVSNEEGSTRNKKDKCMFLLYIQANSVSNSKGQKSKAVSESEGQGPSVEFSIKDLYAIQEIQ 409

  Fly   456 KKPDIYDRLARAIAPSIYENDDIKKGILLQLFGGTKKKHATLGRQNFRSEIHLLLCGDPGTSKSQ 520
            .:.|::..:..::.|.||.:..:|.|:.|.||||.:|......|...|.:.|:|:.||||..|||
Zfish   410 AQEDLFKLIVNSLCPVIYGHLLVKAGLALALFGGCQKYVDDKNRIPIRGDPHMLIVGDPGLGKSQ 474

  Fly   521 MLQYVFNLVPRSQYTSGRGSSAVGLTAYVTKDPETRQLVLQTGALVLADNGVCCIDEFDKMNDST 585
            |||.|.|:.||..|..|..::..|||..:::|..:....|:.|||||.|.|:|||||||||....
Zfish   475 MLQAVCNVAPRGVYVCGNTTTTSGLTVSLSRDSGSGDYALEAGALVLGDQGICCIDEFDKMGSQH 539

  Fly   586 RSVLHEVMEQQTLSIAKAGIICQLNARTSILAAANPAESQWNKRKNIIDNVQLPHTLLSRFDLIF 650
            :::| |.||||::|:|||||:|.|.|||||:|||||....:||.|.:.:|:::...|||||||:|
Zfish   540 QALL-EAMEQQSISLAKAGIVCTLPARTSIIAAANPVGGHYNKGKTVSENLKMGSALLSRFDLVF 603

  Fly   651 LVLDPQDEIFDKRLASHL----------VSLYYVTR---HEEEDTMFDMS--------------- 687
            ::||..:|..|..|:.|:          ||....||   ||...::.::|
Zfish   604 ILLDTPNEDHDHLLSEHVMAMRAGKSGAVSGAAATRFNTHESSISILEVSSEKPLADTLKLVPGE 668

  Fly   688 --------VLRDYIAYAREHLSPTLSDEAQQRLIQAYVDMRKVGAGRGQISAYPRQLESLIRLSE 744
                    :||.|:.|||.::.||||.||.|.|...|:::||............|||||||||:|
Zfish   669 AFDPIPHQLLRKYVGYARHYVHPTLSAEAAQVLQDFYLELRKQNQTADSTPITTRQLESLIRLTE 733

  Fly   745 AHAKVRLSNQVELLDVEEAWRLHREALKQSATDPLS---GKIDVGILTTGLSTAARKKRADLVAA 806
            |.|:|.|..:....|.|:.    .|.:|.|.||..|   |::|......|...:.|.|....|:|
Zfish   734 ARARVELREKATQSDAEDV----VEIMKHSLTDTYSDEFGRLDFDRSQLGSGMSNRSKVKKFVSA 794

  Fly   807 IKENLKKKGKVLTVPYQKLF--SDIKE-GSQIMITREQFEDALKEVQDEGAIVVMG 859
            :.:..::..|       .:|  .|::: ...:.|....||..:..:.::|.::..|
Zfish   795 LNKLAERTSK-------SMFELQDLRQLAKDLQIQVVDFEGFICALNEQGYLLKKG 843

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpa	NP_001286160.1	PHA03307	2..>150	CDD:223039	8/32 (25%)
		MCM_N	168..267	CDD:379644	24/128 (19%)
		MCM	270..772	CDD:214631	188/549 (34%)
mcm8	XP_002665161.2	Mcm2	110..801	CDD:224162	220/702 (31%)
		MCM_N	111..235	CDD:291233	22/127 (17%)
		AAA	451..605	CDD:99707	77/154 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820