DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1620 and MIDEAS

DIOPT Version :9

Sequence 1:	NP_001260777.1	Gene:	CG1620 / 35678	FlyBaseID:	FBgn0033183	Length:	586	Species:	Drosophila melanogaster
Sequence 2:	NP_001354639.1	Gene:	MIDEAS / 91748	HGNCID:	19853	Length:	1099	Species:	Homo sapiens

Alignment Length:	724	Identity:	135/724 - (18%)
Similarity:	208/724 - (28%)	Gaps:	339/724 - (46%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 NSDLAVTPTKRERRKSPATSSDNNSTSV--------------QPPMSPSS--------------- 62
            |...|..|.|:::::.|.........::              ||...|..
Human   238 NPVAAFPPQKQQQQQQPQQQQQQQQAALPQMPLFENFYSMPQQPSQQPQDFGLQPAGPLGQSHLA 302

  Fly    63 --SVADTTFEPTIDM-------MVND-------------------------------FDDEATLN 87
              |:|...|.|..||       ::.|                               .|...|..
Human   303 HHSMAPYPFPPNPDMNPELRKALLQDSAPQPALPQVQIPFPRRSRRLSKEGILPPSALDGAGTQP 367

  Fly    88 EEEALADMEAH-----------------SAEDEIATLREESEMPIEELLAKYGGTAASPAMSSSN 135
            .:||..::..|                 .|......|||...:|..|.||..|....:|||.|..
Human   368 GQEATGNLFLHHWPLQQPPPGSLGQPHPEALGFPLELRESQLLPDGERLAPNGREREAPAMGSEE 432

  Fly   136 --------------RSG--SSSRRARRATKRQYQELD--------TEMAHTSTSTSSSTSQLEKH 176
                          |.|  .|:||.|||:    ||.:        .|:|....:...|.|:.::.
Human   433 GMRAVSTGDCGQVLRGGVIQSTRRRRRAS----QEANLLTLAQKAVELASLQNAKDGSGSEEKRK 493

  Fly   177 D--------GIDQEE------EPKEEAD------------KLASPPESGEASSVDTE-------- 207
            .        |::..|      ..:|::.            :...|.|:.:|..:|.:
Human   494 SVLASTTKCGVEFSEPSLATKRAREDSGMVPLIIPVSVPVRTVDPTEAAQAGGLDEDGKGPEQNP 558

  Fly   208 --------------------DAQ--------KYEG---IKK------------------------ 217
                                |||        |.||   ::|
Human   559 AEHKPSVIVTRRRSTRIPGTDAQAQAEDMNVKLEGEPSVRKPKQRPRPEPLIIPTKAGTFIAPPV 623

  Fly   218 -----QHRSHL-----LDLYPDESFVDLAPTCGEETERFTP------------------------ 248
                 .::|||     |..:|.|...:|.|        :||
Human   624 YSNITPYQSHLRSPVRLADHPSERSFELPP--------YTPPPILSPVREGSGLYFNAIISTSTI 680

  Fly   249 -----------LQTLFDEVEAEEEEESESELDDARKI-----IMVGHDYQAEIP---EGLSQYGD 294
                       .:||.....||......|.:.:|..:     |.||..:|||||   :......|
Human   681 PAPPPITPKSAHRTLLRTNSAEVTPPVLSVMGEATPVSIEPRINVGSRFQAEIPLMRDRALAAAD 745

  Fly   295 ILPYENEDQLIWEP------SQVSEREVEEYLAKIQETRSIVPPDDGSETTAGEEGAATGATIEP 353
              |::.:  |:|:|      |:..:|:||:.|                        .|..::|.|
Human   746 --PHKAD--LVWQPWEDLESSREKQRQVEDLL------------------------TAACSSIFP 782

  Fly   354 PAPITAPATPPRAPLATSGAG-DQELVVKDNEQALHLLVQCGYDFKEALRR------KRMNVLPL 411
                              ||| :|||       |||.|.:...|..|.|.:      .|.:..||
Human   783 ------------------GAGTNQEL-------ALHCLHESRGDILETLNKLLLKKPLRPHNHPL 822

  Fly   412 T----DTMSSWSEDECLKFEEGIQRFGKDFYQIRQNQVRTRTMRELVHFYYLWKKSERRDQSFAL 472
            .    .....|...|...|.:||..:.|||:.: |..::|:|:.:.|.|||.:||..:    ...
Human   823 ATYHYTGSDQWKMAERKLFNKGIAIYKKDFFLV-QKLIQTKTVAQCVEFYYTYKKQVK----IGR 882

  Fly   473 NDTIDHMDV 481
            |.|:...||
Human   883 NGTLTFGDV 891

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1620	NP_001260777.1	ELM2	275..320	CDD:279754	17/53 (32%)
		SANT	417..463	CDD:197842	16/45 (36%)
		SANT_MTA3_like	417..462	CDD:212559	15/44 (34%)
MIDEAS	NP_001354639.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..69
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	99..159
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	228..264		5/25 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	276..305		3/28 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	330..349		0/18 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	378..397		1/18 (6%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	410..441		9/30 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	543..563		2/19 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	887..1045		2/5 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900