Protein Alignment CG1620 and MIER1

DIOPT Version :9

• Sequence 1: NP_001260777.1
• Gene: CG1620 / 35678
• FlyBaseID: FBgn0033183
• Length: 586
• Species: Drosophila melanogaster
• Sequence 2: NP_001337459.1
• Gene: MIER1 / 57708
• HGNCID: 29657
• Length: 602
• Species: Homo sapiens
• Alignment Length: 580
• Identity: 175/580 - (30%)
• Similarity: 254/580 - (43%)
• Gaps: 161/580 - (27%)

  Fly    35 TKRERRKSPATSSDNNSTSVQPPMSPSSSVADTTFEPTIDMMVNDFDDEATLNEEEALADMEAHS 99
            |..|.....|||.|:.                  |:|:.||:|:|||||.||.|||.:......|
Human    96 TAHESTGGSATSDDHE------------------FDPSADMLVHDFDDERTLEEEEMMEGETNFS 142

  Fly   100 AEDEIATLREESEMPIEELLAKYGGTAASPAMSSSNRSGSSSRRARRATKRQYQE---LDTEMAH 161
            :  ||..|..|.:|||.|||:.||             .||:.|......:.:.:|   .|.|.|.
Human   143 S--EIEDLAREGDMPIHELLSLYG-------------YGSTVRLPEEDEEEEEEEEEGEDDEDAD 192

  Fly   162 TSTSTSSSTSQLEKH--DGIDQEEEPKEEADKLASPPESGEASSVDTEDAQKYEGIKKQHRSHLL 224
            ...::..|....|::  |...||:|.:...|        ..:.||.::|||
Human   193 NDDNSGCSGENKEENIKDSSGQEDETQSSND--------DPSQSVASQDAQ-------------- 235

  Fly   225 DLYPDESFVDLAPTCGEETERFTPLQTLFDEVEAEEEEESESELD-----DARKIIMVGHDYQAE 284
                               |...|.:..:.:..:|.|||||.:.|     |.:|.||||..:|||
Human   236 -------------------EIIRPRRCKYFDTNSEVEEESEEDEDYIPSEDWKKEIMVGSMFQAE 281

  Fly   285 IPEGLSQYGD-ILPYENEDQLIWEPSQVSEREVEEYLAKIQETRSIVPPDDGSETTAGEEGAATG 348
            ||.|:.:|.: ...|||:|||:|:|         |||   .|.:.|:...|.|..|..|:|
Human   282 IPVGICRYKENEKVYENDDQLLWDP---------EYL---PEDKVIIFLKDASRRTGDEKG---- 330

  Fly   349 ATIEPPAPITAPATPPRAPLATSGAGDQELVVKDNEQALHLLVQCGYDFKEALRRKRMNVLPLTD 413
                      ..|.|..:.            :|||||||:.||:|.:|.:|||||.|.||....:
Human   331 ----------VEAIPEGSH------------IKDNEQALYELVKCNFDTEEALRRLRFNVKAARE 373

  Fly   414 TMSSWSEDECLKFEEGIQRFGKDFYQIRQNQVRTRTMRELVHFYYLWKKSERRD----------Q 468
            .:|.|:|:||..||:|::.:||||:.|:.|:||||::.|.|.|||:||||||.|          :
Human   374 ELSVWTEEECRNFEQGLKAYGKDFHLIQANKVRTRSVGECVAFYYMWKKSERYDFFAQQTRFGKK 438

  Fly   469 SFALNDTI-DHMDVFINEAGGGNGSGNGNGAGIVSGTANS-----NGSCSPHSSNG-HSNGDLSA 526
            .:.|:..: |:||..::|:.....|...:.....|.::||     :|:.|..:.|| .|||....
Human   439 KYNLHPGVTDYMDRLLDESESAASSRAPSPPPTASNSSNSQSEKEDGTVSTANQNGVSSNGPGEI 503

  Fly   527 LEKDTIASPRKPASKSYSIMTGSQAVGNPSGGNRKRCSSASLPLE-DEDNNVEEEPSLST 585
            |.|:             .:......:..|:|||:|       ||. |.|.|..|..:|:|
Human   504 LNKE-------------EVKVEGLHINGPTGGNKK-------PLHADMDTNGYETDNLTT 543

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG1620	NP_001260777.1	ELM2	275..320	CDD:279754	20/45 (44%)
		SANT	417..463	CDD:197842	24/45 (53%)
		SANT_MTA3_like	417..462	CDD:212559	23/44 (52%)
MIER1	NP_001337459.1	ELM2	272..321	CDD:307553	24/60 (40%)
		SANT_MTA3_like	378..422	CDD:212559	23/43 (53%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147982
Domainoid	1	1.000	71	1.000	Domainoid score	I9435
eggNOG	1	0.900	-	-		E1_KOG1194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	194	1.000	Inparanoid score	I3839
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062529at2759
OrthoFinder	1	1.000	-	-		FOG0001261
OrthoInspector	1	1.000	-	-		otm40461
orthoMCL	1	0.900	-	-		OOG6_107398
Panther	1	1.100	-	-	LDO	PTHR10865
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3763
SonicParanoid	1	1.000	-	-		X1119
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.790