DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1620 and mier3a

DIOPT Version :9

Sequence 1:	NP_001260777.1	Gene:	CG1620 / 35678	FlyBaseID:	FBgn0033183	Length:	586	Species:	Drosophila melanogaster
Sequence 2:	NP_001025320.2	Gene:	mier3a / 560884	ZFINID:	ZDB-GENE-050913-97	Length:	531	Species:	Danio rerio

Alignment Length:	527	Identity:	168/527 - (31%)
Similarity:	231/527 - (43%)	Gaps:	156/527 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 SVQPPMSPSSSVADTTFEPTIDMMVNDFDDEATLNEEEALADMEAHSAEDEIATLREESEMPIEE 117
            |..|..|.||.  |..|:||.||:|:|:|||.||.||| :.:.|::.: .|||.|.:|..||:||
Zfish     8 STSPVDSLSSE--DHDFDPTADMLVHDYDDERTLEEEE-MREGESNGS-SEIADLEKEGNMPLEE 68

  Fly   118 LLAKYGGTAASPAMSSSNRSGSSSRRARRATKRQYQELDTEMAHTSTSTSSSTSQLEKHDGIDQE 182
            |||.|                            :|:..|:.:..:||.:||    :|..|.:...
Zfish    69 LLALY----------------------------RYEAGDSVIGGSSTDSSS----VELTDELPDM 101

  Fly   183 EEPKEEADKLASPPESGEASSVDTEDAQKYEGIKKQHRSHLLDLYPDESFVDLAPT-CGEETERF 246
            ...|||..|        :..|.|.|:.|                   .|..||.|: ...||..|
Zfish   102 TLDKEEIAK--------DLLSGDDEETQ-------------------SSADDLTPSVTSHETNDF 139

  Fly   247 TPLQTLFDEVEAEEEEESESELD-----DARKIIMVGHDYQAEIPEGLSQYGD-ILPYENEDQLI 305
            .| :||...|..:.::|||.|.|     |:||.||||.:|||||| .|:.|.| ...|..||||:
Zfish   140 FP-RTLRSNVVYDGDKESEGEEDGLSPEDSRKEIMVGSEYQAEIP-ALACYNDQEKVYAEEDQLL 202

  Fly   306 WEPSQVSEREVEEYLAKIQETRSIVPPDDGSETTAGEEGAATGATIEPPAPITAPATPPRAPLAT 370
            |:|..:.|.:|:.:|..                                            .|:.
Zfish   203 WQPDMLPESKVKSFLLD--------------------------------------------ALSA 223

  Fly   371 SGAGDQE---LVVKDNEQALHLLVQCGYDFKEALRRKRMNVLPLTDTMSSWSEDECLKFEEGIQR 432
            .|..|::   .:||||||||:.|::|.|:..|||.|.|.|.....|.|..|||:||..||..:..
Zfish   224 DGKMDRDGRCSLVKDNEQALYELLKCNYNVPEALERYRSNDKSSKDEMLPWSEEECRNFEHALLL 288

  Fly   433 FGKDFYQIRQNQVRTRTMRELVHFYYLWKKSERRDQSFALN-----------DTIDHMDVFINEA 486
            :.|:|:.|::::|.|||:.|.|.|||:||||||.|.....|           ...|.||..::||
Zfish   289 YEKNFHLIQKHKVSTRTVAECVAFYYMWKKSERFDFFVQQNRFGKKKFSSYPGVTDLMDRLVDEA 353

  Fly   487 GGGNGSGNGNGAGIVSGTA----NSNGSCSPHSS------NGHSNGDLSALEKDTIASPRKPAS- 540
                       .|:|.|:|    :|:|...|.:.      |..:..||||| ..|:||...||.
Zfish   354 -----------EGLVDGSASVCSSSSGRIDPPTEQQLNILNSITASDLSAL-TSTVASVCNPADV 406

  Fly   541 ---KSYS 544
               .|||
Zfish   407 SCLDSYS 413

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1620	NP_001260777.1	ELM2	275..320	CDD:279754	22/45 (49%)
		SANT	417..463	CDD:197842	21/45 (47%)
		SANT_MTA3_like	417..462	CDD:212559	20/44 (45%)
mier3a	NP_001025320.2	ELM2	172..222	CDD:279754	23/94 (24%)
		SANT	273..319	CDD:197842	21/45 (47%)
		SANT_MTA3_like	274..318	CDD:212559	20/43 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581876
Domainoid	1	1.000	100	1.000	Domainoid score	I6968
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	191	1.000	Inparanoid score	I3854
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062529at2759
OrthoFinder	1	1.000	-	-		FOG0001261
OrthoInspector	1	1.000	-	-		otm25086
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10865
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3763
SonicParanoid	1	1.000	-	-		X1119
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	10.030