Protein Alignment CG1620 and MIER2

DIOPT Version :10

• Sequence 1: NP_610287.2
• Gene: CG1620 / 35678
• FlyBaseID: FBgn0033183
• Length: 586
• Species: Drosophila melanogaster
• Sequence 2: XP_047294925.1
• Gene: MIER2 / 54531
• HGNCID: 29210
• Length: 552
• Species: Homo sapiens
• Alignment Length: 570
• Identity: 151/570 - (26%)
• Similarity: 232/570 - (40%)
• Gaps: 151/570 - (26%)

  Fly    36 KRERRKSPATSSDNNSTSVQPPMSPSSSVADTTFEPTIDMMVNDFDDEATLNE--------EEAL 92
            :|:...|....|....:.::..:.|......||...::....:.|:....|::        |||.
Human     2 ERDNASSLGRQSPRVVSCLEHSLCPGEPGLQTTAVVSMGSGDHQFNLAEILSQNYSVRGECEEAS 66

  Fly    93 ADMEAHSAEDEIATLREESEMPIEELLAKYGGTAASPAMSSSNRSGSSSRRARRATKRQYQELDT 157
            ...:....|.|...:.:.::||.:||||.||..|:.|.....:..|..:......|      ||.
Human    67 RCPDKPKEELEKDFISQSNDMPFDELLALYGYEASDPISDRESEGGDVAPNLPDMT------LDK 125

  Fly   158 EMAHTSTSTSSSTSQLEKH--DGIDQEEEPKEEADKLASPPESGEASSVDTEDAQKYEGIKKQHR 220
            |             |:.|.  .| ::|||.:..||.|.....|.|||
Human   126 E-------------QIAKDLLSG-EEEEETQSSADDLTPSVTSHEAS------------------ 158

  Fly   221 SHLLDLYPDESFVDLAPTCGEETERFTPLQTLFDE------VEAEEEEESESELDDARKIIMVGH 279
                ||:|:.|           ..||     |.||      ..:.:.||.....:..:|.||||.
Human   159 ----DLFPNRS-----------GSRF-----LADEDREPGSSASSDTEEDSLPANKCKKEIMVGP 203

  Fly   280 DYQAEIPE-GLSQYGDILPYENEDQLIWEPSQVSEREVEEYLAKIQETRSIVPPDDGSETTAGEE 343
            .:||::.. .|:::.:.: |||||||:|:||.:.||||||:|.:..:.|        ....||
Human   204 QFQADLSNLHLNRHCEKI-YENEDQLLWDPSVLPEREVEEFLYRAVKRR--------WHEMAG-- 257

  Fly   344 GAATGATIEPPAPITAPATPPRAPLATSGAGDQELVVKDNEQALHLLVQCGYDFKEALRRKRMNV 408
                                |:.|     .|:   .|||:||||:.||:|.::.:|||||.|.||
Human   258 --------------------PQLP-----EGE---AVKDSEQALYELVKCNFNVEEALRRLRFNV 294

  Fly   409 LPLTDTMSSWSEDECLKFEEGIQRFGKDFYQIRQNQVRTRTMRELVHFYYLWKKSERRDQSFALN 473
            ..:.|.:.:|||:||..||.|.:..||:|:.|:.|:||||::.|.|.:|||||||||.|. ||..
Human   295 KVIRDGLCAWSEEECRNFEHGFRVHGKNFHLIQANKVRTRSVGECVEYYYLWKKSERYDY-FAQQ 358

  Fly   474 DTIDHMDVFINEAGGGNGSGNGNGAGIVSGTANSNGSCSPHSSNGHSNGDLSALEKDTIASPRKP 538
            ..:                  |....:.|||.:             ::.||...:.|....||..
Human   359 TRL------------------GRRKYVPSGTTD-------------ADQDLDGSDPDGPGRPRPE 392

  Fly   539 ASKSYSIMTGSQAVGNPSGG-NRKRCSSASLPLEDED----NNVEEEPSL 583
            ......:.|...:|...:|| :....:|..||..:..    ..::|.|::
Human   393 QDTLTGMRTDPLSVDGTAGGLDEPGVASDGLPSSEPGPCSFQQLDESPAV 442

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG1620	NP_610287.2	ELM2	275..325	CDD:460214	24/50 (48%)
		SANT_MTA3_like	417..462	CDD:212559	23/44 (52%)
MIER2	XP_047294925.1	ELM2	199..249	CDD:460214	24/50 (48%)
		SANT_MTA3_like	304..348	CDD:212559	23/43 (53%)