DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1620 and Zfp541

DIOPT Version :9

Sequence 1:	NP_001260777.1	Gene:	CG1620 / 35678	FlyBaseID:	FBgn0033183	Length:	586	Species:	Drosophila melanogaster
Sequence 2:	NP_001100928.2	Gene:	Zfp541 / 308108	RGDID:	1310756	Length:	1301	Species:	Rattus norvegicus

Alignment Length:	626	Identity:	122/626 - (19%)
Similarity:	194/626 - (30%)	Gaps:	169/626 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 SSDHSQHSASEASADSGSLANSDLAVTPTKRERRKSPATSSDNNSTSVQPPMSPSSSVADTTFE- 70
            |..|....:.....:.....|.||.  |:.|:...:..:..|         :.||.|.:|...|
  Rat    14 SEGHLPSFSESQGLNCSDTLNRDLG--PSTRDLLYAGLSGLD---------LDPSLSTSDMPSEV 67

  Fly    71 -----PTIDMMVNDFDDEATLNEEEALADMEAHSAEDEIATLREESEMPIEELLAKYGGTAASPA 130
                 .|:.:......|...|.||.|.::.:....:..:.||:...|       |..||.|
  Rat    68 LEDNLDTLSLYSGKDSDSVKLLEEYADSESQTSLQDLGLGTLKVPKE-------ADEGGRA---- 121

  Fly   131 MSSSNRSGSSSRRARRATKRQYQELDTEMAHTSTSTSSSTSQLEKHDGIDQEEEPKEEADKLASP 195
                  :||:.:..|:.:..|...||..:.   ....||.|.|.||.....:|  ::...|:.|
  Rat   122 ------TGSTRKGKRQHSSPQNPLLDCSLC---GKVFSSASSLSKHYLTHSQE--RKHVCKVCS- 174

  Fly   196 PESGEASSVDTEDAQKYEGIKKQHR--SHLLDLYPDESFVDLAPTCGEETERFTPLQTLFDEV-- 256
                             :..|:|..  .|:|.....:.||.:...|.:....:..|:..: ||
  Rat   175 -----------------KAFKRQDHLTGHMLTHQKTKPFVCIEQGCSKSYCDYRSLRRHY-EVQH 221

  Fly   257 ------EAEEEEESESELDDARKIIMVGHDYQAE-IPEGLSQY--------GDILPYENEDQLIW 306
                  ||..||||..:...       .||...: .|.||...        |.:||  |.|.|..
  Rat   222 GVCILKEAPPEEESYGDPTH-------NHDVANQPPPSGLRSLGPPEARSPGSVLP--NRDLLRC 277

  Fly   307 EPSQVSEREVEEYLAKIQETRSIVPPDDGSETTAGEEGAATGATIEPPAPITAPATPPRAPLATS 371
            ..|.:..:::               |..|....:.:..|.:.|...|.:..::..||...|:|..
  Rat   278 IVSSIVHQKI---------------PSPGPAVGSSDTEARSSACACPTSLGSSSCTPASTPVAPG 327

  Fly   372 GAGD---QELVVKDNEQALHLLVQCGYDFKEALRRKRMNVLP---------------LTDTMSSW 418
            ..|.   :|......|.|..:       |.....|...|..|               ...::..|
  Rat   328 TLGSEIPEETHPPRKEAATEM-------FTAVQSRAAENSAPDPPESELESESPRLQRPSSLEGW 385

  Fly   419 SEDE----CLKFEEGIQRFGKDFYQIRQNQVRTRTMRELVHFYYLWKKSERRDQSFALNDTIDHM 479
            .|..    ||..             .|.:.|.:.:.....:|.:|     |...|...|.:   .
  Rat   386 PEGSSLPACLPL-------------FRGHSVPSGSQPSSHNFQWL-----RNLPSCPKNKS---S 429

  Fly   480 DVFINEAGGGNGSGNGNGAGIVSGTANSNGSCSPHSSNGHSNGDLSALEKDTIASPRKPASKSYS 544
            :||:........|..|:..|  ||.:::..|..|..|.|.|..||.......:.:|.:.:|:.
  Rat   430 NVFMVHKPSAVASREGSEGG--SGPSSTPTSVEPSPSLGTSQEDLLPFPPALLKAPGEASSEV-- 490

  Fly   545 IMTGSQAVGNPSGGNRKRC----------SSASLPLEDEDN 575
                .|..|.......|:|          |...|.|:|..|
  Rat   491 ----RQVAGEDETWAPKKCKPDCESFPWQSPTELGLQDAQN 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1620	NP_001260777.1	ELM2	275..320	CDD:279754	12/53 (23%)
		SANT	417..463	CDD:197842	8/49 (16%)
		SANT_MTA3_like	417..462	CDD:212559	8/48 (17%)
Zfp541	NP_001100928.2	COG5236	<80..>227	CDD:227561	37/187 (20%)
		C2H2 Zn finger	142..162	CDD:275368	6/22 (27%)
		zf-C2H2	168..190	CDD:395048	6/39 (15%)
		C2H2 Zn finger	170..190	CDD:275368	6/37 (16%)
		C2H2 Zn finger	198..216	CDD:275368	2/17 (12%)
		PHA03247	<244..672	CDD:223021	64/337 (19%)
		ELM2	1003..1058	CDD:396160
		SANT	1113..1156	CDD:419695
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910