Protein Alignment CG1620 and MIER3

DIOPT Version :10

• Sequence 1: NP_610287.2
• Gene: CG1620 / 35678
• FlyBaseID: FBgn0033183
• Length: 586
• Species: Drosophila melanogaster
• Sequence 2: XP_011541518.1
• Gene: MIER3 / 166968
• HGNCID: 26678
• Length: 566
• Species: Homo sapiens
• Alignment Length: 548
• Identity: 165/548 - (30%)
• Similarity: 230/548 - (41%)
• Gaps: 150/548 - (27%)

  Fly    13 HSASEASADSGSLANSDLAVTPTKRERRKSPATSSDNNSTSVQPPMSPSSSVADTTFEPTIDMMV 77
            |.||:.|.            ||....|..|..:||...|.|.:          |..|:||.:|:|
Human     4 HRASQKSG------------TPHPAAREASFGSSSPVGSLSSE----------DHDFDPTAEMLV 46

  Fly    78 NDFDDEATLNEEEALADMEAHSAEDEIATLREESEMPIEELLAKYGGTAASPAMSSSNRSGSSSR 142
            :|:|||.||.|||.:.  |..:...||..|.:|..||:|:|||.||.....||:::|:.:.|.|
Human    47 HDYDDERTLEEEEMMD--EGKNFSSEIEDLEKEGTMPLEDLLAFYGYEPTIPAVANSSANSSPS- 108

  Fly   143 RARRATKRQYQELDTEMAHTSTSTSSSTSQLEKHDGIDQEEEPKEEADKLASPPESGEASSVDTE 207
                       ||..|:...:.........|...|    :||.:..||.|.....|.|.|
Human   109 -----------ELADELPDMTLDKEEIAKDLLSGD----DEETQSSADDLTPSVTSHETS----- 153

  Fly   208 DAQKYEGIKKQHRSHLLDLYPDESFVDLAPTCGEETERFTPLQTLFDEVEAEEEEESESELDDAR 272
                             |.:|.....:.|  |..:.|         .||| :.|.:|.:..:|.|
Human   154 -----------------DFFPRPLRSNTA--CDGDKE---------SEVE-DVETDSGNSPEDLR 189

  Fly   273 KIIMVGHDYQAEIPEGLSQY-GDILPYENEDQLIWEPSQVSEREVEEYLAKIQETRSIVPPDDGS 336
            |.||:|..||||||..|.:| |:...|||||||:|.|..|.|.:|:|||.: ...|:      ||
Human   190 KEIMIGLQYQAEIPPYLGEYDGNEKVYENEDQLLWCPDVVLESKVKEYLVE-TSLRT------GS 247

  Fly   337 ETTAGEEGAATGATIEPPAPITAPATPPRAPLATSGAGDQELVVKDNEQALHLLVQCGYDFKEAL 401
            |.......|.|.                               .:||||||:.|::|.::.|||:
Human   248 EKIMDRISAGTH-------------------------------TRDNEQALYELLKCNHNIKEAI 281

  Fly   402 RRKRMNVLPLTDTMSSWSEDECLKFEEGIQRFGKDFYQIRQNQVRTRTMRELVHFYYLWKKSERR 466
            .|...|.....:.|::|:|:||..||..:..|||||:.|::|:|||||:.|.|.|||:||||||.
Human   282 ERYCCNGKASQEGMTAWTEEECRSFEHALMLFGKDFHLIQKNKVRTRTVAECVAFYYMWKKSERY 346

  Fly   467 DQSFALN------------DTIDHMDVFINEAGGGNGSGNGNGAGIVSGTANSNGSCSPHSS--- 516
            |. ||..            ...|:||..::|...            :.||.|::...|....
Human   347 DY-FAQQTRFGKKRYNHHPGVTDYMDRLVDETEA------------LGGTVNASALTSNRPEPIP 398

  Fly   517 -------NGHSNGDLSALEKD--TIASP 535
                   |..:..||:||...  |:..|
Human   399 DQQLNILNSFTASDLTALTNSVATVCDP 426

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG1620	NP_610287.2	ELM2	275..325	CDD:460214	27/50 (54%)
		SANT_MTA3_like	417..462	CDD:212559	24/44 (55%)
MIER3	XP_011541518.1	ELM2	192..240	CDD:460214	27/47 (57%)
		SANT_MTA3_like	298..342	CDD:212559	24/43 (56%)
		MIER1_3_C	352..566	CDD:437258	15/87 (17%)