DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment p47 and Ubxn2b

DIOPT Version :9

Sequence 1:	NP_610284.1	Gene:	p47 / 35674	FlyBaseID:	FBgn0033179	Length:	407	Species:	Drosophila melanogaster
Sequence 2:	NP_080810.2	Gene:	Ubxn2b / 68053	MGIID:	1915303	Length:	331	Species:	Mus musculus

Alignment Length:	338	Identity:	120/338 - (35%)
Similarity:	177/338 - (52%)	Gaps:	56/338 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 PAATKAKPKFATL-SDMSKESSSDDDQQA-------------FYAGGSDRSGQQVLGPPKRKNFR 148
            |:|...:...|.| .|..|..||..|:..             .|:|.....|..::.||..|...
Mouse    22 PSARDLQLALAELYEDEMKCKSSKPDRSTPATCRSPRTPPHRLYSGDHKYDGLHIVQPPTGKIVN 86

  Fly   149 EQLTDMMRSAQEQNIAEVGPSTSSG------SASGGSGGAVWGQGMRLGMTDNDHTAVGTKKPAA 207
            |    :.:.|:|.....:..:|.|.      |.:||        |.|||.:        ..|.:.
Mouse    87 E----LFKEAREHGAVPLNEATRSSREDKTKSFTGG--------GYRLGNS--------FYKRSE 131

  Fly   208 TI--ENK---PVVVLKLWSQGFSIDGGELRHYDDPQNKEFLETVMRGEIPQEL--LEMGRMVNVD 265
            .|  ||:   ..|:||||..|||:|.||||.|.||.|.:|||:|.|||.|.||  |..|..||:|
Mouse   132 YIYGENQLQDVQVLLKLWRNGFSLDDGELRPYSDPTNAQFLESVKRGETPLELQRLVHGAQVNLD 196

  Fly   266 VEDHRHEDFKRQPVP-QTFKGSGQKLGSPVANLVTEAPTVPVALSPGEAANQEASARDAINLNSE 329
            :|||:.:::.:..:. :.|.|.||||||    |..|..:.|  .||.|......:|  |:.::..
Mouse   197 MEDHQDQEYIKPRLRFKAFSGEGQKLGS----LTPEIVSTP--SSPEEEDKSILNA--AVLIDDS 253

  Fly   330 APSTTLQIRLADGSRLAAQFNLSHTVSDIRRFIQTARPQYSTSNFILVSSFPTRELSDDNSTIEK 394
            .|:|.:||||||||||..:||.:|.:.|:|.||..:||:::|::||||:|||::||:|:..|:::
Mouse   254 MPTTKIQIRLADGSRLVQRFNSTHRILDVRDFIVRSRPEFATTDFILVTSFPSKELTDETVTLQE 318

  Fly   395 AGLKNAALMQRLK 407
            |.:.|..::|:||
Mouse   319 ADILNTVILQQLK 331

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
p47	NP_610284.1	UBA_ceTYDP2_like	6..42	CDD:270612
		SEP	211..300	CDD:197786	45/94 (48%)
		p47_UBX	329..407	CDD:176365	36/77 (47%)
Ubxn2b	NP_080810.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..70		11/47 (23%)
		SEP	140..232	CDD:197786	45/95 (47%)
		p47_UBX	255..331	CDD:176365	36/75 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167833360
Domainoid	1	1.000	87	1.000	Domainoid score	I7988
eggNOG	1	0.900	-	-		E1_KOG2086
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	257	1.000	Inparanoid score	I3131
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1175850at2759
OrthoFinder	1	1.000	-	-		FOG0001623
OrthoInspector	1	1.000	-	-		otm42463
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X629
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.760