DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment p47 and Nsfl1c

DIOPT Version :9

Sequence 1:	NP_610284.1	Gene:	p47 / 35674	FlyBaseID:	FBgn0033179	Length:	407	Species:	Drosophila melanogaster
Sequence 2:	NP_938085.1	Gene:	Nsfl1c / 386649	MGIID:	3042273	Length:	372	Species:	Mus musculus

Alignment Length:	408	Identity:	156/408 - (38%)
Similarity:	223/408 - (54%)	Gaps:	46/408 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 RGDLIAQFIEITGTDENVARFYLSSCDWDIEHALGNYWSTQADLPVPVPTVGHADNPKPKPTSSS 68
            |.|.:.:|:.:|||:|:.|||:|.|..||::.||.:::....|  ..:.|:..|
Mouse     5 RQDALREFVAVTGTEEDRARFFLESAGWDLQIALASFYEDGGD--EDIVTISQA----------- 56

  Fly    69 GASASASAAGATKSADSAVATSSASVDIAPAATKAKPKFATLSDMSKESSSDDDQQA-FYAGGSD 132
                               ..||.|...||:..:.......:.|..:|...::.|:: ||||||:
Mouse    57 -------------------TPSSVSRGTAPSDNRVTSFRDLIHDQDEEEEEEEGQRSRFYAGGSE 102

  Fly   133 RSGQQVLGPPKRKNFREQLTDMMRSAQEQNIAEVGPSTSS-GSASGGSGGAVWGQGMRLGMTDND 196
            |||||::|||::|:..|.:.|:.:.|:|.....|...|.| |..|.....|  |.|.|||....:
Mouse   103 RSGQQIVGPPRKKSPNELVDDLFKGAKEHGAVAVERVTKSPGETSKPRPFA--GGGYRLGAAPEE 165

  Fly   197 HTAVGTKKPAATIENKPVVVLKLWSQGFSIDGGELRHYDDPQNKEFLETVMRGEIPQEL--LEMG 259
            .:|....:..........||||||..|||:|.|:||.|.||.|.:|||::.|||:|.||  |..|
Mouse   166 ESAYVAGERRRHSGQDVHVVLKLWKTGFSLDNGDLRSYQDPSNAQFLESIRRGEVPAELRRLAHG 230

  Fly   260 RMVNVDVEDHRHEDF-KRQPVPQTFKGSGQKLGSPVANLVTEAPTVPVALSPGEAANQEASARDA 323
            ..||:|:||||.||| |.:...:.|.|.||||||       .||.|....||.:.|..||.|..:
Mouse   231 GQVNLDMEDHRDEDFVKPKGAFKAFTGEGQKLGS-------TAPQVLNTSSPAQQAENEAKASSS 288

  Fly   324 INLNSEAPSTTLQIRLADGSRLAAQFNLSHTVSDIRRFIQTARPQYSTSNFILVSSFPTRELSDD 388
            |.:|...|:|.:|||||||.||..:||.||.:||||.||..|||..:.::|:|:::||.:||:|:
Mouse   289 ILINEAEPTTNIQIRLADGGRLVQKFNHSHRISDIRLFIVDARPAMAATSFVLMTTFPNKELADE 353

  Fly   389 NSTIEKAGLKNAALMQRL 406
            |.|:::|.|.||.::|||
Mouse   354 NQTLKEANLLNAVIVQRL 371

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
p47	NP_610284.1	UBA_ceTYDP2_like	6..42	CDD:270612	15/35 (43%)
		SEP	211..300	CDD:197786	47/91 (52%)
		p47_UBX	329..407	CDD:176365	40/78 (51%)
Nsfl1c	NP_938085.1	UBA_p47	7..45	CDD:270533	15/37 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	54..73		6/48 (13%)
		Nuclear localization signal	111..117		3/5 (60%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	140..159		7/20 (35%)
		Nuclear localization signal	174..177		0/2 (0%)
		SEP	180..272	CDD:197786	50/98 (51%)
		p47_UBX	294..372	CDD:176365	40/78 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167833362
Domainoid	1	1.000	87	1.000	Domainoid score	I7988
eggNOG	1	0.900	-	-		E1_KOG2086
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41114
Inparanoid	1	1.050	257	1.000	Inparanoid score	I3131
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54012
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001623
OrthoInspector	1	1.000	-	-		otm42463
orthoMCL	1	0.900	-	-		OOG6_102041
Panther	1	1.100	-	-	LDO	PTHR23333
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1594
SonicParanoid	1	1.000	-	-		X629
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790