DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment p47 and UBXN2B

DIOPT Version :9

Sequence 1:	NP_610284.1	Gene:	p47 / 35674	FlyBaseID:	FBgn0033179	Length:	407	Species:	Drosophila melanogaster
Sequence 2:	NP_001071087.1	Gene:	UBXN2B / 137886	HGNCID:	27035	Length:	331	Species:	Homo sapiens

Alignment Length:	367	Identity:	124/367 - (33%)
Similarity:	184/367 - (50%)	Gaps:	53/367 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 GHADNPKPKPTSSSG----ASASASAAGATKSADSAVATSSASVDIAPAATKAKPKFATLSDMSK 115
            |....|..:...|||    ::.....|.|....|.....||.|  ..|.||..|
Human     4 GGGPEPGEQERRSSGPRPPSARDLQLALAELYEDEVKCKSSKS--NRPKATVFK----------- 55

  Fly   116 ESSSDDDQQAFYAGGSDRSGQQVLGPPKRKNFREQLTDMMRSAQEQNIAEVGPSTSSGSASG-GS 179
              |.....|.||:...:.||..::.|...|...|    :.:.|:|.....:..:|   .||| ..
Human    56 --SPRTPPQRFYSSEHEYSGLNIVRPSTGKIVNE----LFKEAREHGAVPLNEAT---RASGDDK 111

  Fly   180 GGAVWGQGMRLGMT--DNDHTAVGTKKPAATIENK---PVVVLKLWSQGFSIDGGELRHYDDPQN 239
            ..:..|.|.|||.:  .......|        ||:   ..::|||||.|||:|.||||.|::|.|
Human   112 SKSFTGGGYRLGSSFCKRSEYIYG--------ENQLQDVQILLKLWSNGFSLDDGELRPYNEPTN 168

  Fly   240 KEFLETVMRGEIPQEL--LEMGRMVNVDVEDHRHEDFKRQPVP-QTFKGSGQKLGSPVANLVTEA 301
            .:|||:|.|||||.||  |..|..||:|:|||:.:::.:..:. :.|.|.||||||....:|:
Human   169 AQFLESVKRGEIPLELQRLVHGGQVNLDMEDHQDQEYIKPRLRFKAFSGEGQKLGSLTPEIVS-- 231

  Fly   302 PTVPVALSPGEAANQEASARDAINL-NSEAPSTTLQIRLADGSRLAAQFNLSHTVSDIRRFIQTA 365
                   :|.....::.|..:|:.| :...|:|.:||||||||||..:||.:|.:.|:|.||..:
Human   232 -------TPSSPEEEDKSILNAVVLIDDSVPTTKIQIRLADGSRLIQRFNSTHRILDVRNFIVQS 289

  Fly   366 RPQYSTSNFILVSSFPTRELSDDNSTIEKAGLKNAALMQRLK 407
            ||:::..:||||:|||.:||:|::.|:.:|.:.|..|:|:||
Human   290 RPEFAALDFILVTSFPNKELTDESLTLLEADILNTVLLQQLK 331

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
p47	NP_610284.1	UBA_ceTYDP2_like	6..42	CDD:270612
		SEP	211..300	CDD:197786	45/94 (48%)
		p47_UBX	329..407	CDD:176365	36/77 (47%)
UBXN2B	NP_001071087.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26		5/21 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	40..65		9/39 (23%)
		SEP	140..232	CDD:197786	44/100 (44%)
		p47_UBX	253..331	CDD:176365	36/77 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143199
Domainoid	1	1.000	86	1.000	Domainoid score	I8091
eggNOG	1	0.900	-	-		E1_KOG2086
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	254	1.000	Inparanoid score	I3194
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1175850at2759
OrthoFinder	1	1.000	-	-		FOG0001623
OrthoInspector	1	1.000	-	-		otm40391
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X629
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	9.760