DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11141 and Tecpr2

DIOPT Version :9

Sequence 1:	NP_001286159.1	Gene:	CG11141 / 35672	FlyBaseID:	FBgn0033177	Length:	710	Species:	Drosophila melanogaster
Sequence 2:	XP_006240680.1	Gene:	Tecpr2 / 314456	RGDID:	1307503	Length:	1417	Species:	Rattus norvegicus

Alignment Length:	754	Identity:	197/754 - (26%)
Similarity:	317/754 - (42%)	Gaps:	162/754 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MASSKELCSIREWAPLTEVIERIPARLQRGFFPANLNLTCVDATEEFLAMGSDAGIVFWYNRHTG 65
            |||..|..:.||:.||..::..||.::||||....:.||.:|...:::|:||..|:::.|.||..
  Rat     1 MASVSEPVTFREFCPLYYLLNAIPTKIQRGFRSIVVYLTALDTNGDYIAVGSSIGMLYLYCRHLN 65

  Fly    66 EMQKLKAEVATR-ITCVRVVNSVEYMVAAGCANGQVSIFQIQKELPRDLDLVAPCTKSRPIERYT 129
            :|:|...|..|. ||.|::::..:.:||.|.|:|:|::||:...||         .:::.:.|:.
  Rat    66 QMKKYNFEGKTESITVVKLLSCFDDLVAVGTASGRVAVFQLVSSLP---------GRNKQLRRFD 121

  Fly   130 IRDLHKCVVSCCEWSKNGMKLYSGDRQGVVVLTELDYQAHLSKSVEILSEAYEIVQLSVRQSYLL 194
            :..:||..::...||.|||||:|||.:|.:|.:.||....:..|..:|.|...||||...|..||
  Rat   122 VTGVHKTSITALAWSPNGMKLFSGDDKGKIVYSSLDLDQGICNSHLVLEEPSSIVQLDYSQKVLL 186

  Fly   195 VATLYRCIVCQMDAQTSQWNITQVGKKDRKQLIDCGAIFL----KKQEANKPQLVCGRPGLRFWV 255
            |:||.|.::    ..|.:..:.|:|.:.||.....||.|:    |:.:..   |...|||||.|.
  Rat   187 VSTLQRSLL----FYTEEKAVKQIGSQPRKSTGKFGACFIPGLCKQSDLT---LYAARPGLRLWK 244

  Fly   256 ADAAGNVSKTVIFRDAVLRSPTWEIPI-LNPKQRSEPSGTHHTSASTSSTRHSGLAD--GDVGYV 317
            ||..|.|..|.|.:|......|   |. |.|  |.|||.....||   ..:|.||..  ...|:|
  Rat   245 ADVHGTVQATFILKDVFAGGVT---PFELYP--RLEPSDGGSCSA---PEKHLGLVSCFFQEGWV 301

  Fly   318 ASSNFRQLYLYDGHDSLLVTHDDATLYVLNLDRLKVEAVARGLRKILDFCVCGKEIFVLEGNRTL 382
            .|.|...:||.|       |.:.||:           |...||..|:.......|||.|:|:|.:
  Rat   302 LSWNEYSIYLLD-------TVNQATV-----------AGLEGLGDIVSVSCTENEIFFLKGDRNI 348

  Fly   383 LRLAPLPEPPNKTAKVIFNPLMPP-PVPVLGSHLSQLESPIELQAEPVLQNAEECFELSPVEQLN 446
            :|::..||  ...:.|..:|.|.. ...|.|.||.:.......:|.  |:.:
  Rat   349 IRISSRPE--GLASIVRDSPEMARCSEQVHGQHLEKSLGGTVCEAR--LRGS------------- 396

  Fly   447 LNVPIEIAVESPLTQQNRRLEIFRRIGEMDFEQSIVHTTRKTSVGKPPEASGV------GIVEIG 505
                   :|.|.:..:.|                    :|.:|.......||:      ...|:|
  Rat   397 -------SVASSVASEQR--------------------SRSSSFNSTDSGSGLLPPGSQAAPELG 434

  Fly   506 HETHELRLPLTNAATLMEASYCQMENNGLASPLDMKAAFLQHLPDALSPTTLQKTV--------- 561
            |...    |.:...:::.:.  ..:...:..|:.:|....:..|:..|.:|...::
  Rat   435 HSGQ----PSSQRFSVISSE--DFDQELIVKPIKVKKRRRKRKPEGGSKSTCHSSLESTPCSELP 493

  Fly   562 AEKAKTLAAELDLPEVHLAP--LSQEELHAVQAQTP--QIS-----DPLIRCY--PTHLEEASIQ 615
            |:..::|:.:|    |.||.  ||...:..:..:.|  :||     |.:|:..  |..|.:..:.
  Rat   494 ADSPQSLSTDL----VSLASSVLSGSSVDQLSTEPPDQEISPSGELDGIIQDNNGPQTLHDLEVP 554

  Fly   616 TSSRENATNPADDYHVGEPVDGIRSFGVSKRKMAP----------LKFVLSQPKPTLKLEENRDD 670
            .|:    .:|.|:.:             |.||.|.          ||.||:.|   |:..|:..|
  Rat   555 GST----PSPVDEEN-------------SPRKEASQCDHTQDTDLLKGVLTLP---LQPGEDEGD 599

  Fly   671 EEYTSFLPDFRRAGDPLAIHKETPATSDSNTSSEWEFLD 709
            .:.||.|.:........|||.|. ...:.|:|:|.:.:|
  Rat   600 ADVTSELEEKPGPAADAAIHTEL-CLQEQNSSAEQQEVD 637

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11141	NP_001286159.1	WD40 repeat	138..188	CDD:293791	21/49 (43%)
CG11141	NP_001286159.1	WD40 repeat	194..228	CDD:293791	10/33 (30%)
Tecpr2	XP_006240680.1	WD40	36..366	CDD:225201	118/373 (32%)
		WD40 repeat	37..73	CDD:293791	12/35 (34%)
		WD40 repeat	79..121	CDD:293791	14/50 (28%)
		WD40 repeat	130..168	CDD:293791	15/37 (41%)
		WD40 repeat	175..197	CDD:293791	11/25 (44%)
		WD40 repeat	215..256	CDD:293791	16/43 (37%)
		Hyd_WA	953..980	CDD:399457
		Hyd_WA	1003..1033	CDD:399457
		Tectonin	1185..1379	CDD:408963
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166337621
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3621
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0008133
OrthoInspector	1	1.000	-	-		oto98638
orthoMCL	1	0.900	-	-		OOG6_107952
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.640