DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11141 and Hps5

DIOPT Version :9

Sequence 1:	NP_001286159.1	Gene:	CG11141 / 35672	FlyBaseID:	FBgn0033177	Length:	710	Species:	Drosophila melanogaster
Sequence 2:	NP_001005247.2	Gene:	Hps5 / 246694	MGIID:	2180307	Length:	1126	Species:	Mus musculus

Alignment Length:	698	Identity:	149/698 - (21%)
Similarity:	259/698 - (37%)	Gaps:	178/698 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 ANLNLTCVDATEEFLAMGSDAGIVFWYNRHTGEMQKL----KAEVATRITCVRVVNSVEYMVAAG 94
            :.|..|.:..:.::||:||..|.:....: .|..|:|    :....::|.|..  :..:| ||..
Mouse    33 SRLRCTSIAVSRKWLALGSTGGGLNLIQK-DGWKQRLFLSHREGAISQIACCS--HDDDY-VAVA 93

  Fly    95 CANGQVSIFQIQKELPRDLDLVAPCTKSRPIERYTIRDLHK--CVVSCCEWSKNGMKLYSGDRQG 157
            .:.|.|.::::.:|           .:.:| ||..:...||  .|.:.| |....::::.||..|
Mouse    94 TSQGLVVVWELNQE-----------RRGKP-ERIHVSSEHKGRKVTALC-WDTAVLRVFVGDHVG 145

  Fly   158 VVVLTELD--YQAHLSKSV------EILSEAYEIVQLSVRQSYLLVATLYRCIVCQMDAQTSQWN 214
            .|...:|:  .||..:.:.      .:|:....:|||......|||::|.|..:|    .|.:..
Mouse   146 KVSAIKLNTLKQAKAAAAFVMFPVQTVLTVDSCVVQLDYLDGRLLVSSLTRSFLC----DTEREK 206

  Fly   215 ITQVGKKDRKQLIDCGAIFLKKQEA--NKPQLVCGRPGLRFWVADAAGNVSKTVIFRDAVLRSPT 277
            ..::|.|:|..  :.||.|...:.|  .:|.:.|.|||.|.|..:..|.|..|..|:..:...|
Mouse   207 FWKIGNKERHG--EYGACFFPGRCAGGQQPVIYCARPGSRMWEVNFDGEVLSTHQFKKLLSMPP- 268

  Fly   278 WEIPILNPKQRSEPSGTHHTSASTSSTRHSGLADGDVGYVASSNFRQLYLYDGHDSLLVTHDDAT 342
              :|::.  .||||...|...:|.|      ||           |.:|.....|  .::|..:..
Mouse   269 --LPVIT--ARSEPQYDHTVGSSQS------LA-----------FPKLLHLSEH--CVLTWTEKG 310

  Fly   343 LYVLNLDRLKVEAVARGLRKILDFCVCGKEIFVLEGNRTLLRLAPLP--------------EPPN 393
            :|:.....::| .:...::.|.|..|...|:|.|..|..:..|:.|.              :...
Mouse   311 IYIFIPQNVQV-LLWSEVKDIQDVAVYKNELFCLHFNGKISHLSLLSVERCVERLLRRGLWDLAA 374

  Fly   394 KTAKVIFNPLMPPPV--PVLGSHLSQLESPIELQAEPVLQNAEECFEL-SPVEQLNLNV-PIEIA 454
            :|..:..|.::....  .:....|..|:|.::|.|         |.|| |.::.|.|.. |:|.|
Mouse   375 RTCCLFQNSIITSRARKTLTADKLEHLKSQLDLTA---------CSELISQLDDLILRFEPLESA 430

  Fly   455 VESPLTQQNRRLEI------------------FRRIGEMDFEQSIVHTTRKTSVGKPPEASGVGI 501
            ..|      ||..|                  .||..:.|.:...:|:...:...:..|.:
Mouse   431 CSS------RRSSISSHESFSILDSGIYRIISSRRGSQSDEDSCSLHSQTFSEDERLKEFA---- 485

  Fly   502 VEIGHETHELRLPLTNAATLMEASYCQMENNGLASPLDMKAAF-----------------LQHLP 549
               .|:..|.......|....|::    .::.:.|.:|...||                 ||.:.
Mouse   486 ---SHQEEEQPEQGCGANRNEESA----SHSPVMSEVDKSEAFLPFSIALPFRSPSPLVSLQAVK 543

  Fly   550 DALSPTTLQKTVAEKAKTL--AAELDLP----------------------------EVHLAPLSQ 584
            |::| :.::|| .||..||  :.||..|                            |:|..|...
Mouse   544 DSVS-SFVRKT-TEKIGTLHGSPELKEPFESKDADRAHEEEVSAVTCPLEEDTEEKEIHQPPKED 606

  Fly   585 --EELHAVQAQT-PQISDPLIRCYPTHLEEASIQTSSRENATNPADDY 629
              :||.|..|:. .::.|||:...|..|....::..|:...|....|:
Mouse   607 RLQELTAATAEAMTKLLDPLVLFEPKVLRMVLLEWLSQLEKTFAMKDF 654

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11141	NP_001286159.1	WD40 repeat	138..188	CDD:293791	13/57 (23%)
CG11141	NP_001286159.1	WD40 repeat	194..228	CDD:293791	9/33 (27%)
Hps5	NP_001005247.2	WD40 repeat	37..75	CDD:293791	9/38 (24%)
		WD40 repeat	81..117	CDD:293791	10/50 (20%)
		WD40 repeat	126..165	CDD:293791	10/39 (26%)
		WD40 repeat	173..210	CDD:293791	11/40 (28%)
		WD40 repeat	218..257	CDD:293791	13/38 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	461..514		7/63 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	560..579		4/18 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3621
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4159
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	4	3.800