DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11141 and W09G3.6

DIOPT Version :9

Sequence 1:	NP_001286159.1	Gene:	CG11141 / 35672	FlyBaseID:	FBgn0033177	Length:	710	Species:	Drosophila melanogaster
Sequence 2:	NP_493417.1	Gene:	W09G3.6 / 173249	WormBaseID:	WBGene00012369	Length:	1125	Species:	Caenorhabditis elegans

Alignment Length:	780	Identity:	165/780 - (21%)
Similarity:	281/780 - (36%)	Gaps:	228/780 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 EVIERIPAR-------LQRGFFPAN----LNLTCVDATEEFLAMGSDAGIVFWYNRHTGEMQK-- 69
            :.|:|||..       |....||||    :..|||.:|.:.|.:|:..|.|:.::|:..:.:.
Worm    17 DFIDRIPTHFLVELTSLDELAFPANSTKRVKYTCVASTSKSLCLGTSTGSVYIFSRYAAKSRSRT 81

  Fly    70 -----LKAEVAT----RITCVRVVNSVEYMVAAGCANGQVSIFQIQKELPRDLDLVAPCTKSRPI 125
                 :..:|.|    :|:.:.|..|.|.| |.|..:|:||:.|:....|..|....|.....|
Worm    82 NSGAPVPVQVFTTRDGQISTISVSPSEELM-AIGGDSGRVSVAQLNNGQPPTLIYSTPGDARSP- 144

  Fly   126 ERYTIRDLHKCVVSCCEWSKNGMKLYSGDRQGVVVLTELDYQAHLSKSVEILSEAY--------E 182
            :|          |:...||.:...:|||...|.:       ..|...|..:...|:        |
Worm   145 DR----------VTALSWSADLKTVYSGHSSGTL-------HCHRLTSRSVFRAAHQKLMKFDGE 192

  Fly   183 IVQLSVRQSYLLVATLYRCIVCQMDAQTSQWNITQVGKKDRKQLIDCGAIFLKKQEANKPQLVCG 247
            |:|:...||::|:||.....:..:::.|    |.|||||.|......||.::..:.|   .:|..
Worm   193 IIQIDTLQSHVLIATSLAAHLFHVESGT----IQQVGKKTRSSPAPLGACYVHGESA---FIVAA 250

  Fly   248 RPGLRFWVADAAGNVSKTVIFRDA--VLRSPTWEIPILNPKQRSEPSGTHHTSASTSSTRHSGLA 310
            ||..|.|.|:..|.|.:|..:|.:  :.|:|........|...::..|.|..:...|..:
Worm   251 RPNGRLWEANLVGVVYRTHQYRQSGQIPRAPPISFRSAFPTDSAQFCGLHPDNQDVSLQK----- 310

  Fly   311 DGDVGYVASSNFRQLYLYDGHDSLLVTHDDATLYVLNLDRLKVEAVARGLRKILDFCVCGKEIFV 375
               :..:...|       .|..||:|:...:.:.|:.::..:|...|.....|||...||.:|||
Worm   311 ---IHVIHVDN-------GGGRSLVVSTAGSRICVVEMETSRVTCCAELDYDILDVSTCGNDIFV 365

  Fly   376 L-------------EGNRTLLRLAPLPEPPNKTAKVIF----------NPLMPPPVPVLGS---- 413
            |             |..:||.:|         ..|.||          :|.:..|:|:|.:
Worm   366 LLNDSKGLRKFSVFERQKTLEKL---------NLKGIFMQSAQLVLFCSPHITYPMPLLTTIIEG 421

  Fly   414 ------------------------------------HLSQLESPIELQAEP-----------VLQ 431
                                                .:.:.||..:|:..|           |||
Worm   422 LGTLSRKKETEKLQLALQKMLDERKINQSTYDNNIEEMERKESLKKLKKTPESKKLPSGVHRVLQ 486

  Fly   432 NAEEC------FELSPVEQLNLN-----------VPIEIAVESPLTQQNRRLEIFRRIGEMDF-E 478
            .|.:|      |..|..:.|...           :|:|.....|.:.:.|: |.:|:.|..|. |
Worm   487 TAAQCSGYDDDFNFSTPQALRERSRSSPCGPESPIPLEKRASEPASLELRQ-EYWRKNGTPDVCE 550

  Fly   479 QSIVHTTRKTSVGKPPEASGVGIVE----------IGHETHELRLPLTNAATLMEASYCQMENNG 533
            :.|:|..|:....:..|.    :||          .|.:..|:|  .|...|:..|:....| ..
Worm   551 EDILHRARQILEDENSEK----LVEKESLRTLLQLEGIKKDEIR--FTPTVTIANAAKALAE-LA 608

  Fly   534 LASPLDMKAAF----LQHLPDALSPT---------------------TLQKTVAEKAKTLAAELD 573
            ||.|:|:.|.:    .|:..:..:|.                     .||.|..:...|: ..:.
Worm   609 LAVPVDLTAIWNSGNSQNSQNPQNPEKNGSKISKNPPQIVKVIRPGHRLQTTTTKPIATV-TPIT 672

  Fly   574 LPEVHLAPLSQEELHAVQAQTPQISDPL---------IRCYPTHLEEASIQTSSRENATN-PADD 628
            :|..:...::...:..:..:..:..|.:         |:.:.:|..:..|.|||..::.| |..|
Worm   673 VPVANADDVAVNNMGMISEEMRRKQDEMWLDLRLTQHIKKHSSHANDDVIITSSPTSSNNVPKSD 737

Fly 629 628
Worm 738 737

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11141	NP_001286159.1	WD40 repeat	138..188	CDD:293791	13/57 (23%)
CG11141	NP_001286159.1	WD40 repeat	194..228	CDD:293791	11/33 (33%)
W09G3.6	NP_493417.1	WD40	<88..178	CDD:295369	27/108 (25%)
		WD40 repeat	99..134	CDD:293791	12/35 (34%)
		WD40 repeat	147..187	CDD:293791	10/46 (22%)
		WD40 repeat	195..228	CDD:293791	12/36 (33%)
		WD40 repeat	236..276	CDD:293791	13/42 (31%)
		WD40 repeat	283..339	CDD:293791	10/70 (14%)
		WD40 repeat	353..394	CDD:293791	14/49 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160157887
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4159
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.870