Protein Alignment CG11141 and HPS5

DIOPT Version :9

• Sequence 1: NP_001286159.1
• Gene: CG11141 / 35672
• FlyBaseID: FBgn0033177
• Length: 710
• Species: Drosophila melanogaster
• Sequence 2: XP_011518164.1
• Gene: HPS5 / 11234
• HGNCID: 17022
• Length: 1156
• Species: Homo sapiens
• Alignment Length: 709
• Identity: 138/709 - (19%)
• Similarity: 247/709 - (34%)
• Gaps: 214/709 - (30%)

  Fly    34 ANLNLTCVDATEEFLAMGSDAGIVF------WYNR----HTGEMQKLKAEVATRITCVRVVNSVE 88
            :.|..|.:..:.::||:||..|.:.      |.:|    |       :....:::.|  .::..:
Human    33 SRLKCTSIAVSRKWLALGSSGGGLHLIQKEGWKHRLFLSH-------REGAISQVAC--CLHDDD 88

  Fly    89 YMVAAGCANGQVSIFQIQKELPRDLDLVAPCTKSRPIERYTIRDLHK--CVVSCCEWSKNGMKLY 151
            | ||...:.|.|.::::.:|           .:.:|.:.| :...||  .|.:.| |....::::
Human    89 Y-VAVATSQGLVVVWELNQE-----------RRGKPEQMY-VSSEHKGRRVTALC-WDTAILRVF 139

  Fly   152 SGDRQGVVVLTELDYQAHLSKSVEILSEAYE--------IVQLSVRQSYLLVATLYRCIVCQMDA 208
            .||..|.|...:|:.......:...:....:        :|||......||:::|.|..:|
Human   140 VGDHAGKVSAIKLNTSKQAKAAAAFVMFPVQTITTVDSCVVQLDYLDGRLLISSLTRSFLC---- 200

  Fly   209 QTSQWNITQVGKKDRKQLIDCGAIFL--KKQEANKPQLVCGRPGLRFWVADAAGNVSKTVIFRDA 271
            .|.:....::|.|:|..  :.||.|.  :.....:|.:.|.|||.|.|..:..|.|..|..|:..
Human   201 DTEREKFWKIGNKERDG--EYGACFFPGRCSGGQQPLIYCARPGSRMWEVNFDGEVISTHQFKKL 263

  Fly   272 VLRSPTWEIPILNPKQRSEPSGTHHTSASTSSTRHSGLADGDVGYVASSNFRQLYLYDGHDSLLV 336
            :...|   :|::.  .||||. ..||:.|:.|.                :|.:|.....|  .::
Human   264 LSLPP---LPVIT--LRSEPQ-YDHTAGSSQSL----------------SFPKLLHLSEH--CVL 304

  Fly   337 THDDATLYVLNLDRLKVEAVARGLRKILDFCVCGKEIFVLEGNRTLLRLAPLPEPPNKTAKVIFN 401
            |..:..:|:.....::| .:...::.|.|..||..|:|.|..|                .||
Human   305 TWTERGIYIFIPQNVQV-LLWSEVKDIQDVAVCRNELFCLHLN----------------GKV--- 349

  Fly   402 PLMPPPVPVLGSHLSQLESPIELQAEPVLQNAEECFELSPVEQLNLNVPIEIAVESPLTQQNRRL 466
                       ||||             |.:.|.|     ||:|.......:|..:....||
Human   350 -----------SHLS-------------LISVERC-----VERLLRRGLWNLAARTCCLFQN--- 382

  Fly   467 EIFRRIGEMDFEQSIVHTTRKTSVGKPPEASGVGIVEIGHETH--------ELRL---PLTNAAT 520
                        ..|....|||......|...   .::.|.|:        ||.|   ||.:|
Human   383 ------------SVIASRARKTLTADKLEHLK---SQLDHGTYNDLISQLEELILKFEPLDSA-- 430

  Fly   521 LMEASYCQMENNGLASPLDMKAAFLQHLPDALSPTTLQKTVAEKAKTLAAELDLPEVHLAPLSQE 585
                  |....:.::|          |...::..:.:.:.::.:..:.:.| |...:|...||::
Human   431 ------CSSRRSSISS----------HESFSILDSGIYRIISSRRGSQSDE-DSCSLHSQTLSED 478

  Fly   586 ELHAVQAQTPQISDPLIRCYPTH-----LEEASIQTSSRENATNPADDYHVGEPVDGIRSFGVSK 645
            | ...:..:.|..|...:|..:|     :..|.:...:.:|.|              ...||:
Human   479 E-RFKEFTSQQEEDLPDQCCGSHGNEDNVSHAPVMFETDKNET--------------FLPFGI-- 526

  Fly   646 RKMAPLKFVLSQPKPTLKLEENRDDEEYTSFLPDFRRAGDPLAIHKETPATSDSNTSSE 704
                ||.|  ..|.|.:.|:..:  |..:||            :.|.|......:||.:
Human   527 ----PLPF--RSPSPLVSLQAVK--ESVSSF------------VRKTTEKIGTLHTSPD 565

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG11141	NP_001286159.1	WD40 repeat	138..188	CDD:293791	10/57 (18%)
		WD40 repeat	194..228	CDD:293791	8/33 (24%)
HPS5	XP_011518164.1	WD40 repeat	37..75	CDD:293791	9/44 (20%)
		WD40 repeat	81..118	CDD:293791	9/51 (18%)
		WD40 repeat	126..165	CDD:293791	8/39 (21%)
		WD40 repeat	173..210	CDD:293791	9/40 (23%)
		WD40 repeat	218..257	CDD:293791	12/38 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3621
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4159
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	4	3.800