DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11141 and tecpr2

DIOPT Version :9

Sequence 1:	NP_001286159.1	Gene:	CG11141 / 35672	FlyBaseID:	FBgn0033177	Length:	710	Species:	Drosophila melanogaster
Sequence 2:	XP_002936632.2	Gene:	tecpr2 / 100495806	XenbaseID:	XB-GENE-5827246	Length:	1396	Species:	Xenopus tropicalis

Alignment Length:	805	Identity:	201/805 - (24%)
Similarity:	330/805 - (40%)	Gaps:	185/805 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SSKELCSIREWAPLTEVIERIPARLQRGFFPANLNLTCVDATEEFLAMGSDAGIVFWYNRHTGEM 67
            :::.:.:.:|:.||..::..|||::|:||....:.||.:||..:|:|:||..|:::.|.|||.:|
Frog     2 AAQRVGTFKEFCPLYSILNAIPAKVQKGFRSILVYLTALDANSDFIAVGSSIGMLYLYCRHTSQM 66

  Fly    68 QKLKAEVATR-ITCVRVVNSVEYMVAAGCANGQVSIFQIQKELPRDLDLVAPCTKSRPIERYTIR 131
            :|...|..|. |:.|::::..:.:||.|..:|:|::||:...||         .:::.:.|:.:.
Frog    67 KKYSLEGKTESISVVKLLSCFDDLVAVGTVSGRVAVFQLVSPLP---------GRNKQLRRFDVL 122

  Fly   132 DLHKCVVSCCEWSKNGMKLYSGDRQGVVVLTELDYQAHLSKSVEILSEAYEIVQLSVRQSYLLVA 196
            .:||..::...||.|||||:|||.:|.::.::||:...|.....||.|...:|||...|..|||:
Frog   123 GIHKSNITALAWSPNGMKLFSGDDRGKIIQSDLDFDKGLCNPSLILEELSSVVQLDYSQKVLLVS 187

  Fly   197 TLYRCIVCQMDAQTSQWNITQVGKKDRKQLIDCGAIF---LKKQEANKPQLVCGRPGLRFWVADA 258
            |..||::    ..|.:..:.|||.:.||.....||.|   |.||...|  |...|||||.|.:|.
Frog   188 TTQRCLL----FYTEEKAVKQVGTQPRKSNGKYGACFIPGLCKQSDLK--LFASRPGLRLWKSDV 246

  Fly   259 AGNVSKTVIFRDAVLRSPTWEIPILNPKQRSEPSGTHHTSASTSSTRHSGLADGDVGYVASSNFR 323
            .|.|..|.|.:|.......:|   |.|:..     |.:..:...|.:|.||
Frog   247 HGCVQSTFILKDMFKGLEQFE---LYPRVE-----TSNKDSFVLSEKHFGL-------------- 289

  Fly   324 QLYLYDGHDSLLVTHDDATLYVLNLDRLKVEAVARGLRK---ILDFCVCGKEIFVLEGNRTLLRL 385
             ||.: .|:..:::.|:.::|:::...   :||..||..   |:.......|||.::|:|.::|:
Frog   290 -LYCF-LHEGWVLSWDEYSIYLIDTVN---QAVIGGLESSGDIVSVSCTNNEIFFIKGDREIIRI 349

  Fly   386 APLPEPPNKTAKVIFNPLMPP---PVPVL---GSH----LSQLESPIELQAEPV---------LQ 431
            :.:||      ..:|..|..|   ..||.   |.|    ||:::...::..:.:         ::
Frog   350 SNMPE------GALFASLHSPFRAHTPVFTEDGKHHIGALSEMKENNKIDVQSIKTEKIQLCAIE 408

  Fly   432 NAEECFE--------------------LSPVEQLNLNVPIEIAVE--SPLTQQNRRLEIFRRIGE 474
            :.|...:                    .|....::....:.:..|  ||...|....:.|..|..
Frog   409 DEESLLDQGTDMRIRTCSLPADEVKSRSSSTNSIDSGFSLTVTAEPGSPNNGQRPTSQRFSIISN 473

  Fly   475 MDFEQSIVHTTRKTSVGKPPEASGVGIVEIG---------HETHELRLPLT-NAATLMEASYCQM 529
            .||:|.:|..:.|....|...     .||.|         ..|.....||| |:........|.:
Frog   474 EDFDQELVVKSMKVKKKKKKR-----YVENGLKNQDACSRESTPSTDSPLTLNSDFFSATEICPV 533

  Fly   530 ---------------ENNG-LASPLDMKAAFLQHLPDALSPTTLQKTVAEKAKTLAAELDLPEVH 578
                           :|.| |.:.:|:.:|.   .|....||.|.......||.....||:...:
Frog   534 SSIDHLSSQESLFSGKNQGVLDNSIDVFSAV---QPTETFPTILGNGSNPPAKQTEELLDVNSDN 595

  Fly   579 LA-PLSQEELHAVQAQTPQISDPLIRCYPTHLEEASIQTSSRENATNPADDYHVGEPVDGIRSFG 642
            .| ||...|..::.|....::|||         |.::.......|..|..|      .|.|....
Frog   596 NADPLPPAECDSISAVNLLMTDPL---------ELNVLMVKNNAAFLPEKD------PDYIDCCA 645

  Fly   643 VSK---------RKMAPLKFVLSQPKPTLKLEENRD-------DEEY----------TSFLPDFR 681
            |.|         .|...:.:.|.:.||   ||.|:|       |:::          :||:.|
Frog   646 VDKCPTVLETLSSKNCNIAYGLEEEKP---LESNKDEILILDEDQQFQEKSRTWQVSSSFIED-- 705

  Fly   682 RAGDPLAIHKETPATSD--SNTSSE 704
               .||   ..|..||.  ||.|.|
Frog   706 ---SPL---NSTYCTSQSPSNDSEE 724

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11141	NP_001286159.1	WD40 repeat	138..188	CDD:293791	20/49 (41%)
CG11141	NP_001286159.1	WD40 repeat	194..228	CDD:293791	11/33 (33%)
tecpr2	XP_002936632.2	WD40	34..419	CDD:225201	120/432 (28%)
		WD40 repeat	39..73	CDD:293791	13/33 (39%)
		WD40 repeat	78..123	CDD:293791	12/53 (23%)
		WD40 repeat	130..167	CDD:293791	14/36 (39%)
		WD40 repeat	174..207	CDD:293791	13/36 (36%)
		Hyd_WA	933..960	CDD:368922
		Hyd_WA	983..1013	CDD:368922
		Hyd_WA	1167..1195	CDD:368922
		Hyd_WA	1268..1296	CDD:368922
		Hyd_WA	1311..1339	CDD:368922
		TECPR	1334..1366	CDD:214782
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0008133
OrthoInspector	1	1.000	-	-		oto105334
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4159
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.030