DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11141 and hps5

DIOPT Version :9

Sequence 1:	NP_001286159.1	Gene:	CG11141 / 35672	FlyBaseID:	FBgn0033177	Length:	710	Species:	Drosophila melanogaster
Sequence 2:	NP_001083008.2	Gene:	hps5 / 100037388	ZFINID:	ZDB-GENE-070410-80	Length:	1133	Species:	Danio rerio

Alignment Length:	795	Identity:	170/795 - (21%)
Similarity:	294/795 - (36%)	Gaps:	231/795 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 RLQRGFFPANLNLTCVDATEEFLAMGSDAGIVFWYNRHTGEMQKL----KAEVATRITCVRVVNS 86
            ||..|    .:..||:..:.::||:|:.||.:....| .|..|||    |....|:::|   ...
Zfish    28 RLDSG----RIKCTCLSVSRKWLALGTSAGGLHLIQR-DGWKQKLILTHKEGSITQVSC---CPH 84

  Fly    87 VEYMVAAGCANGQVSIFQIQKELPRDLDLVAPCTKSRPIERYTIRDLHK--CVVSCCEWSKNGMK 149
            .|..:|...:.|.|.::::..|           .:.|| ||.::...|:  .|.|.| |....::
Zfish    85 DEDFIAVATSQGLVVVWELHLE-----------RRGRP-ERASVSWEHRGVTVTSLC-WDTVALR 136

  Fly   150 LYSGDRQGVVVLTELDYQAHLSKS-------VEILSEA-YEIVQLSVRQSYLLVATLYRCIVCQM 206
            :::||..|.|...... .:.|.|.       |:.::.. ..:|||.....:|::::|.||.:|
Zfish   137 VFAGDMGGKVSCVRAG-SSKLGKGSAFVIFPVQTVTTVDSRVVQLGYTDGHLVISSLSRCYLC-- 198

  Fly   207 DAQTSQWNITQVGKKDRKQLIDCGAIFLKKQEANK---------PQLVCGRPGLRFWVADAAGNV 262
              .|.:....:||.|:|..  :.||.||.:..|.:         |.|.|.|||.|.|.|..:|.|
Zfish   199 --DTEREKFWRVGNKERDG--EFGACFLTQGLAGQRGQLVGCPAPLLFCARPGSRIWEASFSGEV 259

  Fly   263 SKTVIFRDAVLRSPTWEIPILNPKQRSEPSGTHHTSASTSSTRHSGLADGDVGYVASSNFRQLYL 327
            ..|..|:..:...|   :|:::.|  :||   |.....|:.              .|..|.:|..
Zfish   260 LSTHQFKQLLAVPP---LPLVSCK--NEP---HFNPTQTNP--------------QSLAFPRLLQ 302

  Fly   328 YDGHDSLLVTHDDATLYVLNLDRLKVEAVARGLRKILDFCVCGKEIFVLEGNRTLLRLAPLPEPP 392
            :.  |..|:|..|:.:|:......:| .:...::.:|:..|...::|.|.|:..|
Zfish   303 FG--DQNLLTWTDSAIYIFTPHSGQV-LLWTEVKDVLEISVFRNDLFCLHGDGHL---------- 354

  Fly   393 NKTAKVIFNPLMPPPVPVLGSHLSQLESP---IE-----------------LQAEPVLQNAEECF 437
                                ||:| |.||   :|                 .|.......|.:..
Zfish   355 --------------------SHMS-LVSPDRCVERLMKRENWTIAATVCCMFQHAITTSKARKSL 398

  Fly   438 ELSPVEQLNLNVPIEIAVESPLTQQ--NRRLEIFRRIGEMDFEQSIVHTTRKTSVGKPPEASGV- 499
            .:..:|.|      :..:.|...||  .:..|:..::..:|...|    :|::|:.. .|:..|
Zfish   399 SIDRLEHL------KAQLNSTSQQQLIGQLEEVISKLEPLDSACS----SRRSSISS-HESFNVL 452

  Fly   500 --GIVEI----GHETHELRLPLTNAA-----TLMEASYCQME--NNGLAS--------------- 536
              ||..:    |.::.:....|.|.:     .|.|.|:.:.|  :|..||
Zfish   453 DCGIYRVISRRGSQSDDDASSLANQSMLEEERLKEFSFTEEEQVDNDSASVRGEGDRSDLGLQFL 517

  Fly   537 PLDMKA----AFLQHLPDALSPTTLQKTVAEKAKTLAAELDL---PEVH----------LAPLSQ 584
            ||..::    ..||.:.|::|  :..|...||..||....||   |::.          .:|:|:
Zfish   518 PLPFRSKPPRVALQAVRDSVS--SFMKKTTEKINTLQMNADLWPRPDLREGVQGEVASTASPISE 580

  Fly   585 E--------------ELHAVQAQT----PQISDPLIRCYPTHLEEASIQTSS-RENATNPADDYH 630
            |              ||..::|.|    .||.||::...|..|.:...:.:. .|.|..|.|.
Zfish   581 ESEQELNTEESSSESELLELRAATKKAISQIQDPMVLLDPLCLSDVLQEWAPVLERALGPEDQ-- 643

  Fly   631 VGEPVDGIRSFGVSKRKMAPLKFVLS-------QPK----PTLKLEE---NRDDEEYTSFLP--- 678
                :..:.:....::.:...:.|.|       ||:    |....:|   :.::|::....|
Zfish   644 ----ILPVETTNPEEKTLEEEELVSSMSCCVVVQPEISTSPAADPDESATHTEEEDFRESTPCSI 704

  Fly   679 -DFRRAGDPLAIHKE 692
             ..|....|||.|.|
Zfish   705 APVRAQFPPLANHVE 719

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11141	NP_001286159.1	WD40 repeat	138..188	CDD:293791	13/57 (23%)
CG11141	NP_001286159.1	WD40 repeat	194..228	CDD:293791	9/33 (27%)
hps5	NP_001083008.2	WD40 repeat	36..71	CDD:293791	12/35 (34%)
		WD40 repeat	77..120	CDD:293791	11/57 (19%)
		WD40 repeat	125..163	CDD:293791	10/39 (26%)
		WD40 repeat	171..202	CDD:293791	9/34 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3621
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4159
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	4	3.800