Protein Alignment Inos and INO1

DIOPT Version :9

• Sequence 1: NP_477405.1
• Gene: Inos / 35671
• FlyBaseID: FBgn0025885
• Length: 565
• Species: Drosophila melanogaster
• Sequence 2: NP_012382.2
• Gene: INO1 / 853288
• SGDID: S000003689
• Length: 533
• Species: Saccharomyces cerevisiae
• Alignment Length: 523
• Identity: 274/523 - (52%)
• Similarity: 370/523 - (70%)
• Gaps: 17/523 - (3%)

  Fly     7 STLEVISPKVQVDDEFITTDYDYQTSHVKRTADGQLQVHPQTTSLKIRTGRHVP-KLGVMLVGWG 70
            ::::|::.|....|..:.|.|.|:.:.|.:||.|:..|.|.......:.....| |||:||:|.|
Yeast    10 TSVKVVTDKCTYKDNELLTKYSYENAVVTKTASGRFDVTPTVQDYVFKLDLKKPEKLGIMLIGLG 74

  Fly    71 GNNGSTLTAALEANRRQLKWRKRTGVQEANWYGSITQASTVFIGSDEDGGDVYVPMKELLPMVEP 135
            |||||||.|::.||:..::::.:.||::.|::||:||.||:.:|.|.:|.|||.|...|||||.|
Yeast    75 GNNGSTLVASVLANKHNVEFQTKEGVKQPNYFGSMTQCSTLKLGIDAEGNDVYAPFNSLLPMVSP 139

  Fly   136 DNIIVDGWDISGLHLGDAMRRAEVLDVALQDQIYDQLAQLRPRPSIYDPDFIAANQSDRADNVI- 199
            ::.:|.||||:...|.:||:|::||:..||.::..:::.::|.||||.||||||||.:||:|.|
Yeast   140 NDFVVSGWDINNADLYEAMQRSQVLEYDLQQRLKAKMSLVKPLPSIYYPDFIAANQDERANNCIN 204

  Fly   200 ---------RGTRLEQYEQIRKDIRDFRERSGVDSVIVLWTANTERFADVQPGLNTTSQELIASL 255
                     || :....::||:||::|:|.:.:|.|||||||||||:.:|.||:|.|.:.|:.|:
Yeast   205 LDEKGNVTTRG-KWTHLQRIRRDIQNFKEENALDKVIVLWTANTERYVEVSPGVNDTMENLLQSI 268

  Fly   256 EANHSEVSPSTIFAMASIAEGCTYINGSPQNTFVPGLIQLAEEKNVFIAGDDFKSGQTKIKSVLV 320
            :.:|.|::||||||.|||.||..||||||||||||||:||||.:..||||||.||||||:||||.
Yeast   269 KNDHEEIAPSTIFAAASILEGVPYINGSPQNTFVPGLVQLAEHEGTFIAGDDLKSGQTKLKSVLA 333

  Fly   321 DFLVGAGIKPVSIASYNHLGNNDGKNLSAPQQFRSKEISKSNVVDDMVASNRLLYGP--DEHPDH 383
            .|||.|||||||||||||||||||.|||||:||||||||||:|:||::|||.:||..  .:..||
Yeast   334 QFLVDAGIKPVSIASYNHLGNNDGYNLSAPKQFRSKEISKSSVIDDIIASNDILYNDKLGKKVDH 398

  Fly   384 VVVIKYVPYVGDSKRAMDEYTSEIMMGGHNTLVIHNTCEDSLLATPLILDLVILGELSTRIQLRN 448
            .:||||:..|||||.|||||.||:|:||||.:.|||.|||||||||||:||:::.|..||:..:.
Yeast   399 CIVIKYMKPVGDSKVAMDEYYSELMLGGHNRISIHNVCEDSLLATPLIIDLLVMTEFCTRVSYKK 463

  Fly   449 AE--KESA-PWVPFKPVLSLLSYLCKAPLVPQGSQVVNSLFRQRAAIENILRGCIGLPPISHMTL 510
            .:  ||.| .:..|.|||:.|||..||||...|...||.|.:||.|:||.||..||||..:.:..
Yeast   464 VDPVKEDAGKFENFYPVLTFLSYWLKAPLTRPGFHPVNGLNKQRTALENFLRLLIGLPSQNELRF 528

  Fly   511 EQR 513
            |:|
Yeast   529 EER 531

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Inos	NP_477405.1	NAD_binding_5	10..513	CDD:294375	273/518 (53%)
INO1	NP_012382.2	NAD_binding_5	66..515	CDD:400381	252/449 (56%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157342216
Domainoid	1	1.000	498	1.000	Domainoid score	I50
eggNOG	1	0.900	-	-		E1_COG1260
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6222
Inparanoid	1	1.050	530	1.000	Inparanoid score	I186
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54110
OrthoFinder	1	1.000	-	-		FOG0004516
OrthoInspector	1	1.000	-	-		oto99549
orthoMCL	1	0.900	-	-		OOG6_100830
Panther	1	1.100	-	-	LDO	PTHR11510
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2161
SonicParanoid	1	1.000	-	-		X3196
TreeFam	1	0.960	-	-
	15	14.790