DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Inos and Isyna1

DIOPT Version :9

Sequence 1:	NP_477405.1	Gene:	Inos / 35671	FlyBaseID:	FBgn0025885	Length:	565	Species:	Drosophila melanogaster
Sequence 2:	NP_076116.1	Gene:	Isyna1 / 71780	MGIID:	1919030	Length:	557	Species:	Mus musculus

Alignment Length:	566	Identity:	336/566 - (59%)
Similarity:	422/566 - (74%)	Gaps:	16/566 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKPTNNSTLEVISPKVQVDDEFITTDYDYQTSHVKRTADGQLQVHPQTTSLKIRTGRHVPKLGVM 65
            |:|.  :.:.|.||.|....|.|...|:|:|:.|.|.. |.|:|.|:.|....||.|.||:||||
Mouse     1 MEPA--AEILVDSPDVVYSPETIEARYEYRTTRVSREG-GVLRVQPRATRFTFRTARQVPRLGVM 62

  Fly    66 LVGWGGNNGSTLTAALEANRRQLKWRKRTGVQEANWYGSITQASTVFIGSDEDGGDVYVPMKELL 130
            |||||||||||||||:.|||.:|.|..|||.:|||:|||:|||.||.:|.||:|.:|:||...||
Mouse    63 LVGWGGNNGSTLTAAVLANRLRLTWPTRTGRKEANYYGSLTQAGTVNLGLDENGREVFVPFSALL 127

  Fly   131 PMVEPDNIIVDGWDISGLHLGDAMRRAEVLDVALQDQIYDQLAQLRPRPSIYDPDFIAANQSDRA 195
            |||.|::::.||||||.|:|.:|||||:|||..||:|::..:..||||||:|.|:||||||:.||
Mouse   128 PMVAPNDLVFDGWDISSLNLAEAMRRAQVLDCGLQEQLWPHMESLRPRPSVYIPEFIAANQTARA 192

  Fly   196 DNVIRGTRLEQYEQIRKDIRDFRERSGVDSVIVLWTANTERFADVQPGLNTTSQELIASLEANHS 260
            ||:|.|||.:|.|||||||||||..:|:|.||||||||||||.:|.||.|.|::.|:.:::.. .
Mouse   193 DNLIPGTRAQQLEQIRKDIRDFRSSAGLDKVIVLWTANTERFCEVVPGRNDTAENLLHTIQLG-L 256

  Fly   261 EVSPSTIFAMASIAEGCTYINGSPQNTFVPGLIQLAEEKNVFIAGDDFKSGQTKIKSVLVDFLVG 325
            ||||||:||:|||.|.|.::|||||||.|||.::||.:::||:.||||||||||:||||||||:|
Mouse   257 EVSPSTLFAVASILEDCAFLNGSPQNTLVPGALELASQRHVFVGGDDFKSGQTKVKSVLVDFLIG 321

  Fly   326 AGIKPVSIASYNHLGNNDGKNLSAPQQFRSKEISKSNVVDDMVASNRLLYGPDEHPDHVVVIKYV 390
            :|:|.:||.||||||||||:|||||.||||||::||:||||||.||.:||.|.|.|||.||||||
Mouse   322 SGLKTMSIVSYNHLGNNDGQNLSAPLQFRSKEVTKSSVVDDMVHSNHVLYAPGERPDHCVVIKYV 386

  Fly   391 PYVGDSKRAMDEYTSEIMMGGHNTLVIHNTCEDSLLATPLILDLVILGELSTRIQLRNAEKESAP 455
            |||||||||:||||||:|:||.||||:||||||||||.|::||||:|.||..|:.. ..:.:..|
Mouse   387 PYVGDSKRALDEYTSELMLGGTNTLVLHNTCEDSLLAAPIMLDLVLLTELCQRVSF-CTDSDPEP 450

  Fly   456 WVPFKPVLSLLSYLCKAPLVPQGSQVVNSLFRQRAAIENILRGCIGLPPISHMTLEQRFDFSTIT 520
             ..|..||||||:|.||||||.||.|||:|||||:.||||.|.|:||||.:||.||.:.:    .
Mouse   451 -QGFHTVLSLLSFLFKAPLVPPGSPVVNALFRQRSCIENIFRACVGLPPQNHMLLEHKME----R 510

  Fly   521 NEPPLKRVKILGQ---PCSVE--SVTNGKKLHANGHSNG-SAKLAT 560
            ..|.:|..:::..   ||..|  ..|||....||||... :.||:|
Mouse   511 PGPGIKPGEVVATSPLPCKKEPTPATNGCTGDANGHPQAPTPKLST 556

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Inos	NP_477405.1	NAD_binding_5	10..513	CDD:294375	319/502 (64%)
Isyna1	NP_076116.1	NAD_binding_5	9..507	CDD:294375	319/501 (64%)
Isyna1	NP_076116.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	512..557		15/45 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167833968
Domainoid	1	1.000	585	1.000	Domainoid score	I209
eggNOG	1	0.900	-	-		E1_COG1260
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6222
Inparanoid	1	1.050	646	1.000	Inparanoid score	I794
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54110
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004516
OrthoInspector	1	1.000	-	-		oto93389
orthoMCL	1	0.900	-	-		OOG6_100830
Panther	1	1.100	-	-	LDO	PTHR11510
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2161
SonicParanoid	1	1.000	-	-		X3196
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.790