DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fa2h and ERG25

DIOPT Version :9

Sequence 1:	NP_610279.3	Gene:	fa2h / 35670	FlyBaseID:	FBgn0050502	Length:	355	Species:	Drosophila melanogaster
Sequence 2:	NP_011574.3	Gene:	ERG25 / 852951	SGDID:	S000003292	Length:	309	Species:	Saccharomyces cerevisiae

Alignment Length:	246	Identity:	53/246 - (21%)
Similarity:	76/246 - (30%)	Gaps:	113/246 - (45%)

- Green bases have known domain annotations that are detailed below.

  Fly   156 YLEMCTKTPWWL---VPLF--W--IPVIVKCAVEEFTTAWQDSNQLAVFSGYFLFGVLLWSFLEY 213
            |...|  .||::   :|.|  |  .|..:..|.|:.               |.|..|||..||..
Yeast    66 YFFRC--LPWFIIDQIPYFRRWKLQPTKIPSAKEQL---------------YCLKSVLLSHFLVE 113

  Fly   214 TLHRWVFH---VKLSNKSGSWLCTFHFMIHGLHHKVPFDPMRLVFPPLPGAVLAAVIYTPLSFVL 275
            .:..|.||   .||                |:..:|||..::.:           .:...|.|||
Yeast   114 AIPIWTFHPMCEKL----------------GITVEVPFPSLKTM-----------ALEIGLFFVL 151

  Fly   276 SHPRVILSGALAGYLCYDMMHYY----LHYGNPSLWAFVHMKRYHHHHH-----------FSHQ- 324
            .                |..||:    .|||       |..|..|..||           ::|.
Yeast   152 E----------------DTWHYWAHRLFHYG-------VFYKYIHKQHHRYAAPFGLSAEYAHPA 193

  Fly   325 ---TLGYG-ISSPLWDVVFKTRIHLRKL----------------RYQLRWS 355
               :||:| :..|:..|::..::||..|                .|...||
Yeast   194 ETLSLGFGTVGMPILYVMYTGKLHLFTLCVWITLRLFQAVDSHSGYDFPWS 244

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fa2h	NP_610279.3	Cyt-b5	6..73	CDD:278597
fa2h	NP_610279.3	FA_hydroxylase	117..341	CDD:294712	47/214 (22%)
ERG25	NP_011574.3	ERG3	35..307	CDD:225546	53/246 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3000
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900