DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fa2h and ERG3

DIOPT Version :9

Sequence 1:	NP_610279.3	Gene:	fa2h / 35670	FlyBaseID:	FBgn0050502	Length:	355	Species:	Drosophila melanogaster
Sequence 2:	NP_013157.1	Gene:	ERG3 / 850745	SGDID:	S000004046	Length:	365	Species:	Saccharomyces cerevisiae

Alignment Length:	212	Identity:	45/212 - (21%)
Similarity:	72/212 - (33%)	Gaps:	80/212 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   154 PWYLEMCTKTPWWLVPL-----FWIPV------IVKCAVEEFTTAWQDSNQLAVFSGYFLF---- 203
            || :.|.| .||:::.|     .::.:      :.|..:|.||               |:|
Yeast   147 PW-MSMLT-VPWFVMELNGHSKLYMKIDYENHGVRKLIIEYFT---------------FIFFTDC 194

  Fly   204 GVLLWSFLEYTLHRWV----FHVKLSNKSGSWLCTFHFMIHGLH------HKVPFDPMRLVFPPL 258
            ||       |..|||:    .:..|......||....|..|..|      ..:.:....|:.|..
Yeast   195 GV-------YLAHRWLHWPRVYRALHKPHHKWLVCTPFASHSFHPVDGFLQSISYHIYPLILPLH 252

  Fly   259 PGAVLAAVIYTPLSF--VLSHPRVILSG--ALAGYLCYDMMHYYLHYGNPSLWAFVHMKRYHHHH 319
            ..:.|  :::|.::|  |:.|....||.  |:.|..|:.:.|.|.:|
Yeast   253 KVSYL--ILFTFVNFWTVMIHDGQYLSNNPAVNGTACHTVHHLYFNY------------------ 297

  Fly   320 HFSHQTLGYGISSPLWD 336
                   .||..:.|||
Yeast   298 -------NYGQFTTLWD 307

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fa2h	NP_610279.3	Cyt-b5	6..73	CDD:278597
fa2h	NP_610279.3	FA_hydroxylase	117..341	CDD:294712	45/212 (21%)
ERG3	NP_013157.1	ERG3	77..350	CDD:225546	45/212 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3000
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900