DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fa2h and FAH2

DIOPT Version :9

Sequence 1:	NP_610279.3	Gene:	fa2h / 35670	FlyBaseID:	FBgn0050502	Length:	355	Species:	Drosophila melanogaster
Sequence 2:	NP_001328972.1	Gene:	FAH2 / 827835	AraportID:	AT4G20870	Length:	237	Species:	Arabidopsis thaliana

Alignment Length:	233	Identity:	96/233 - (41%)
Similarity:	139/233 - (59%)	Gaps:	21/233 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   118 HLVDWSKAMLPQIANITDCYDEWVHKP---VDRPLRLFDPWYLEMCTKTPWWLVPLFWIPVIVKC 179
            :.||.:|.::.|:.::.:.|.||:|:|   |:.| |.|:..:.|..|:|.||.:|..|:||:  |
plant     6 YTVDLNKPLVFQVGHLGEEYQEWIHQPIVCVEGP-RFFESDFWEFLTRTVWWAIPTIWLPVV--C 67

  Fly   180 AVEEFTTAWQDSNQLAVFSGYFL---FGVLLWSFLEYTLHRWVFHVKLSNKSGSWLCTFHFMIHG 241
            .|...:     :::...|....|   ||||.|:.|||||||::||::..:   .|..|.|:::||
plant    68 YVLSIS-----ASKGLTFPQIGLIVAFGVLTWTLLEYTLHRFLFHIQTKS---YWANTAHYLLHG 124

  Fly   242 LHHKVPFDPMRLVFPPLPGAVLAAVIYTPLSFVLSHPR---VILSGALAGYLCYDMMHYYLHYGN 303
            .|||.|.|.:||||||...|:|...:: .|..:|:.|.   .||.|.|.||:.||:.|||||:|.
plant   125 CHHKHPQDGLRLVFPPTATAILLVPLW-KLLHLLATPATAPAILGGILFGYVMYDITHYYLHHGQ 188

  Fly   304 PSLWAFVHMKRYHHHHHFSHQTLGYGISSPLWDVVFKT 341
            |....|.|:|:||.:|||..|..||||:|.|||.||.|
plant   189 PKEPTFKHLKKYHLNHHFRIQDKGYGITSSLWDKVFGT 226

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fa2h	NP_610279.3	Cyt-b5	6..73	CDD:278597
fa2h	NP_610279.3	FA_hydroxylase	117..341	CDD:294712	95/231 (41%)
FAH2	NP_001328972.1	PLN02434	1..237	CDD:178053	96/233 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	143	1.000	Domainoid score	I1503
eggNOG	1	0.900	-	-		E1_COG3000
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	180	1.000	Inparanoid score	I1461
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1049908at2759
OrthoFinder	1	1.000	-	-		FOG0004076
OrthoInspector	1	1.000	-	-		otm3094
orthoMCL	1	0.900	-	-		OOG6_103477
Panther	1	1.100	-	-	O	PTHR12863
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2828
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.830