Protein Alignment fa2h and FA2H

DIOPT Version :9

• Sequence 1: NP_610279.3
• Gene: fa2h / 35670
• FlyBaseID: FBgn0050502
• Length: 355
• Species: Drosophila melanogaster
• Sequence 2: NP_077282.3
• Gene: FA2H / 79152
• HGNCID: 21197
• Length: 372
• Species: Homo sapiens
• Alignment Length: 361
• Identity: 126/361 - (34%)
• Similarity: 194/361 - (53%)
• Gaps: 50/361 - (13%)

  Fly    19 VKYRQQYYDLSRFMHKHPGGINTLKGLNSGDMTARFLKAPP--HSDAAMYLMREYKIDPEDSRKP 81
            |:...:.||||.|:..||||...|:.....|::|. |..||  ||..|...:.:|.:.
Human    27 VRRGARLYDLSSFVRHHPGGEQLLRARAGQDISAD-LDGPPHRHSANARRWLEQYYVG------- 83

  Fly    82 KSSQRETLHHDEDGTLRQRPRETEDKNNNQVDDSME----------HLVDWSKAMLPQIANITDC 136
                  .|..::.|::...|...|:  ..:.|.:||          .||||.|.:|.|:.::.:.
Human    84 ------ELRGEQQGSMENEPVALEE--TQKTDPAMEPRFKVVDWDKDLVDWRKPLLWQVGHLGEK 140

  Fly   137 YDEWVHKPVDRPLRLFDPWYLEMCTKTPWWLVPLFWIPVIVKCA--------------VEEFTTA 187
            ||||||:||.||:|||....:|..:||.|:.||:.|:|:::..:              ...|||.
Human   141 YDEWVHQPVTRPIRLFHSDLIEGLSKTVWYSVPIIWVPLVLYLSWSYYRTFAQGNVRLFTSFTTE 205

  Fly   188 WQDSNQLAVFSGYFLFGVLLWSFLEYTLHRWVFHVKLSNKSGSWLCTFHFMIHGLHHKVPFDPMR 252
            :..:...::|.|.|:.|..|||.:||.:||::||:|..:.| .:|...||::||.|||.|||..|
Human   206 YTVAVPKSMFPGLFMLGTFLWSLIEYLIHRFLFHMKPPSDS-YYLIMLHFVMHGQHHKAPFDGSR 269

  Fly   253 LVFPPLPGAVLAAVIYTPLSFVLSHP--RVILSGALAGYLCYDMMHYYLHYGNPSLWAFVH-MKR 314
            |||||:|.:::..|.|..:..:|...  ..:.:|.|.||:.|||.|||||:|:|...:::: :|.
Human   270 LVFPPVPASLVIGVFYLCMQLILPEAVGGTVFAGGLLGYVLYDMTHYYLHFGSPHKGSYLYSLKA 334

  Fly   315 YHHHHHFSHQTLGYGISSPLWDVVFKT----RIHLR 346
            :|..|||:||..|:|||:.|||..|.|    :.||:
Human   335 HHVKHHFAHQKSGFGISTKLWDYCFHTLTPEKPHLK 370

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fa2h	NP_610279.3	Cyt-b5	6..73	CDD:278597	20/55 (36%)
		FA_hydroxylase	117..341	CDD:294712	97/250 (39%)
FA2H	NP_077282.3	Cyt-b5	15..85	CDD:278597	20/71 (28%)
		FA_hydroxylase	124..366	CDD:294712	96/242 (40%)
		ERG3	<210..367	CDD:225546	66/157 (42%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147899
Domainoid	1	1.000	144	1.000	Domainoid score	I4642
eggNOG	1	0.900	-	-		E1_COG3000
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H56284
Inparanoid	1	1.050	226	1.000	Inparanoid score	I3497
Isobase	1	0.950	-	0	Normalized mean entropy	S2267
OMA	1	1.010	-	-		QHG55743
OrthoDB	1	1.010	-	-		D1049908at2759
OrthoFinder	1	1.000	-	-		FOG0004076
OrthoInspector	1	1.000	-	-		oto90708
orthoMCL	1	0.900	-	-		OOG6_103477
Panther	1	1.100	-	-	LDO	PTHR12863
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R279
SonicParanoid	1	1.000	-	-		X2828
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750